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The episode features Patrick R. Coyle speaking with Mark Lovern about how model-informed drug development can help teams make smarter, earlier decisions about clinical development, commercial viability, and patient benefit. They explore why approval alone does not guarantee success, how quantitative models can inform investment choices, and why patient access, health economics, and profitability need to be part of the same conversation from the start.

In this episode

• Why drug development teams should consider commercial viability and patient benefit earlier in the development process
• How net present value and probability of technical and regulatory success can shape better portfolio decisions
• Why an independent, objective review can help organizations avoid chasing weak development programs
• How health economics and outcomes research can support payer and access planning before approval
• What rare diseases reveal about balancing societal benefit with sustainable investment
• How model-informed drug development, synthetic control arms, and virtual twins can improve decision-making
• Why real-world data, patient monitoring, consent, and data governance matter after a therapy reaches patients

Mark's views are his own and are not presented on behalf of his employer or any other organization.

Explore the frameworks behind Patients + Profitability™: The 10 Exits of Therapy™ at patrickrcoyle.com and The 5 Layers of GTN™ at nextgengtn.com.

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The episode features Patrick Coyle speaking with Roger Ouimet, VP of PMO at Project Farma and 30-year Navy veteran. They discuss how service, operational discipline, and accountability carry over into pharmaceutical manufacturing, where quality and reliable supply can directly affect patients.

In this episode

• How Roger Ouimet’s 30 years in the Navy shaped his approach to pharmaceutical manufacturing
• Why serving patients who may never be seen in person is a shared mission across the military and pharma
• How the “Blue Mile” at Novo Nordisk helped keep patient impact and quality visible to employees
• Why project managers must balance speed, risk mitigation, and product quality
• How role clarity and accountable leadership help teams raise concerns and prevent quality failures
• Why AI should support project managers while humans remain responsible for decisions and review
• The difference between projects and programs, and how PMOs can align work with organizational strategy

Roger's views are his own and are not presented on behalf of his employer or any other organization.

Explore the frameworks behind Patients + Profitability™: The 10 Exits of Therapy™ at patrickrcoyle.com and The 5 Layers of GTN™ at nextgengtn.com.

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In "Safety as a Culture with Joe Gilliland," Patrick R. Coyle and Joe Gilliland discuss safety, patient care and the choices organizations make every day. Joe shares how a fatal workplace incident early in his career reinforced his commitment to preventing harm. He explains why safety depends on more than written procedures or low incident rates.

In this episode

• How a workplace tragedy shaped Joe's approach to safety and investigation
• Why safety should be foundational, not a priority that competes with other goals
• How listening to employees can reveal risks that might otherwise be missed
• What incident-rate metrics can and cannot tell us about risk
• Why patient-first thinking and worker safety belong in the same conversation
• Joe's perspective on volunteerism and giving back to the community

Joe's views are his own and are not presented on behalf of his employer or any other organization.

Explore the frameworks behind Patients + Profitability™: The 10 Exits of Therapy™ at patrickrcoyle.com and The 5 Layers of GTN™ at nextgengtn.com.

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In this episode of Patients + Profitability, Patrick R. Coyle sits down with Melissa Dragic Swoope, certified specialty pharmacist, healthcare executive, and founder and managing principal of TROJE Health Strategies, to talk about closing the last mile in healthcare. Melissa shares how an early patient encounter as a pharmacist in Hawaii shaped the way she listens to patients, and what she learned building specialty pharmacy and patient experience programs, including founding the Walmart Healthcare Research Institute and training frontline teams with the Disney Institute. The conversation explores where strategy and operations meet, why patient experience is an undervalued signal of operational failure, how injection training and direct-to-consumer models help patients start and stay on therapy, and why patients and profitability must remain part of the same conversation.

Explore the frameworks behind Patients + Profitability™: The 10 Exits of Therapy™ at patrickrcoyle.com and The 5 Layers of GTN™ at nextgengtn.com.

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In this episode of Patients + Profitability, Patrick Coyle sits down with pharmaceutical and rare disease leader Suzanne Morgan to explore the human side of patient access and healthcare innovation. Suzanne shares insights from more than three decades in the pharmaceutical industry, discussing her journey from big pharma to rare disease, the deep connection between patient services and advocacy, and why access to therapy is about far more than processes and programs. The conversation explores the importance of human connection in healthcare, the role of AI, raising awareness for rare diseases, supporting patients and families throughout their journey, and finding purpose through leadership, service, and faith. A thoughtful conversation about patient impact, innovation, advocacy, and why patients and profitability must remain part of the same conversation.

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In this episode of Patients + Profitability™, Patrick Coyle sits down with Dilip Raghunathan, a healthcare technology leader with deep expertise in AI, data, biometrics, and clinical development. Dilip shares his perspective on how technology and responsible AI can remove friction from clinical development and help therapies reach patients faster.

Together, Patrick and Dilip explore the evolving role of AI and data in healthcare, the importance of scalable and compliant technology, and how smarter innovation can improve patient outcomes while creating greater efficiency across the healthcare ecosystem.

LinkedIn: https://www.linkedin.com/in/dilipraghunathan/

Disclaimer: The views and opinions expressed in this episode are those of the individual speakers and do not necessarily reflect the views, positions, or policies of their employers, organizations, or affiliated entities

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Full episode, transcript and clips: patrickrcoyle.com/podcast-by-patrick/episode-1-charlotte-rocker/

In this episode of Patients and Profitability, Patrick R. Coyle sits down with Charlotte Rocker, a life sciences leader with nearly 20 years of experience spanning clinical research, healthcare communications, consulting, startups, health data, and pharmaceuticals. Charlotte shares her perspective on connecting patient outcomes with financial sustainability, the importance of humanizing healthcare data, and how innovation, technology, and AI can help patients access treatments faster. Together, Patrick and Charlotte explore the difference between surviving and truly living, treatment-free remission, patient access, leadership, and why putting patients first can ultimately strengthen the entire healthcare ecosystem.

Linkedin : ⁠linkedin.com/in/charlotte-rocker-bb99945⁠

Disclaimer: The views and opinions expressed in this episode are those of the individual speakers and do not necessarily reflect the views, positions, or policies of their employers, organizations, or affiliated entities

Go deeper at NextGen GTN™: The NextGen GTN™ Philosophy.

Explore the frameworks behind Patients + Profitability™: The 10 Exits of Therapy™ at patrickrcoyle.com and The 5 Layers of GTN™ at nextgengtn.com.

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Patients + Profitability™ is where healthcare leaders explore what it really takes to improve patient outcomes while building financially sustainable organizations.

In every episode, we go beyond industry buzzwords and unpack the strategies, insights, and lessons shaping the future of patient access, commercialization, market access, healthcare economics, and innovation. Our guests share real-world experiences, breakthrough ideas, and practical approaches that help organizations create better outcomes for both patients and business.

If you're a pharmaceutical, biotechnology, finance, market access, or patient services leader looking to navigate a rapidly changing healthcare landscape, you're in the right place.