Episodi

  • #242 Hair Loss Treatments: Minoxidil, Topical Dutasteride, Microneedling, and PRP/Placental Exosomes

    #242 Hair Loss Treatments: Minoxidil, Topical Dutasteride, Microneedling, and PRP/Placental Exosomes
    Oct 15 2026
    In this solo Hart2Heart Podcast episode (focused on male androgenetic alopecia), Dr. Mike Hart reviews hair-loss treatments, emphasizing that regrowth is harder if follicles are gone after 12–18 months. He highlights minoxidil (topical or oral), noting similar efficacy between 2.5 mg and 5 mg oral dosing, comparable results between oral 5 mg and topical 5% twice daily, and that adding 0.01% tretinoin may allow once-daily topical use; combining oral and topical is unstudied but not necessarily dangerous. He advises avoiding systemic DHT blockers due to side effects, favoring 0.05% topical dutasteride for minimal blood DHT reduction, and recommends weekly microneedling (~0.75 mm) without applying products immediately after. As growth-factor adjuncts, he prioritizes PRP or placental exosomes, discusses limited evidence for ketoconazole shampoo and copper peptides, warns DHT-derived anabolic steroids won't be helped by dutasteride, and reviews emerging anti-androgen options and their systemic-risk concerns. Oral vs. Topical Minoxidil for Hair Loss — Mariana Alvares Penha et al., JAMA Dermatology https://pubmed.ncbi.nlm.nih.gov/38598226/ Minoxidil and Tretinoin Combination Treatment — Hyo Seung Shin et al., American Journal of Clinical Dermatology https://pubmed.ncbi.nlm.nih.gov/17902730/ Topical Dutasteride 0.05% for Male Pattern Hair Loss — Veerendra Kumar Panuganti et al., Cureus https://pubmed.ncbi.nlm.nih.gov/40909044/ Ketoconazole 2% Shampoo for Hair Loss (Nizoral) — C. Piérard-Franchimont et al., Dermatology https://pubmed.ncbi.nlm.nih.gov/9669136/ Microneedling for Hair Regrowth — Rachita Dhurat et al., International Journal of Trichology https://pubmed.ncbi.nlm.nih.gov/23960389/ Platelet-Rich Plasma (PRP) for Hair Loss — C. Donnelly et al., Journal of Cosmetic Dermatology https://pubmed.ncbi.nlm.nih.gov/38284294/ Exosomes for Hair Regeneration — Mohammed A. Al Ameer et al., Clinical, Cosmetic and Investigational Dermatology https://pubmed.ncbi.nlm.nih.gov/40955427/ AHK-Cu Copper Peptide and Hair Growth Research — Hyun Keol Pyo et al., Archives of Pharmacal Research https://pubmed.ncbi.nlm.nih.gov/17703734/ Emerging Hair Loss Treatments: Clascoterone and Pyrilutamide — Shivali Devjani et al., Drugs https://pubmed.ncbi.nlm.nih.gov/37166619/ GT20029: Emerging Hair Loss Treatment — Ruiming Hu et al., Journal of Dermatological Treatment https://pubmed.ncbi.nlm.nih.gov/41328006/ Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:34 Podcast Intro and Scope 01:56 Realistic Regrowth Expectations 02:47 Minoxidil Dosing and Use 07:23 Topical Dutasteride Strategy 11:26 Adjunct Shampoo Option 12:16 Microneedling Done Right 14:55 PRP and Exosomes Boosters 16:47 Copper Peptides Hype Check 19:05 Other Add Ons and Big Four Recap 20:16 Steroids and DHT Reality 22:32 Future Anti Androgen Treatments 28:12 Wrap Up and Final Takeaways The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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    30 min
  • #241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price

    #241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price
    Oct 8 2026
    Dr. Mike Hart and Dr. Ira Price explore how medicine is adapting as patients gain greater access to emerging treatments, health information, and tools once limited to physicians. They discuss unapproved peptides and GLP-1 drugs, the growing shift toward personalized and patient-centered care, and the challenges doctors face when evidence and regulation lag behind real-world use. The conversation expands into Canada's opioid crisis, drug decriminalization, fentanyl and medetomidine contamination, emergency-room strain, physician burnout, and broader problems within the Canadian healthcare system. They also examine medical cannabis, CBD and lesser-known cannabinoids, psychedelic medicine, sleep, longevity, and the importance of balancing individual choice with evidence, clinical judgment, and responsible medical guidance. Dr. Ira Price is an emergency physician, sports medicine specialist, and longtime cannabinoid-medicine practitioner whose work sits at the intersection of acute care, emerging therapeutics, and patient-centered medicine. Over nearly two decades working with cannabinoids and years on the front lines of emergency care, he has developed a strong focus on helping patients navigate treatments that often move faster than traditional medical guidelines. His approach emphasizes collaboration rather than gatekeeping, encouraging physicians to remain lifelong learners while helping patients critically evaluate evidence, understand risks and benefits, and make more informed decisions about their health. He brings a practical perspective shaped by emergency medicine, sports medicine, cannabinoid research and clinical practice, and firsthand experience with the evolving challenges facing modern healthcare. Medical Cannabis or Cannabinoids for Chronic Non-Cancer and Cancer Related Pain — Li Wang et al., including Dr. Ira Price / The BMJ H2H 241 IRA PRICE TRANSCRIPT BMJ https://www.bmj.com/content/374/bmj.n1034 Therapeutic Potential of Cannabidiol (CBD) in Anxiety Disorders: A Systematic Review and Meta-Analysis — Kevin Han, Jia-Yu Wang, Peng-Yun Wang & Yue-Chu-Han Peng H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/38924898/ EPIDIOLEX (Cannabidiol) — Jazz Pharmaceuticals H2H 241 IRA PRICE TRANSCRIPT EPIDIOLEX.com https://www.epidiolex.com/what-is-epidiolex Acute Effects of Cannabigerol on Anxiety, Stress, and Mood — Carrie Cuttler, Amanda Stueber, Ziva D. Cooper & Ethan Russo / Scientific Reports H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/39003387/ CBD and THCV in Patients With Type 2 Diabetes — Khalid A. Jadoon et al. / Diabetes Care H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/27573936/ Dependence Potential and Acute Toxicity of Psychoactive Substances — Robert S. Gable / American Journal of Drug and Alcohol Abuse H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/8213692/ Tru Niagen / Nicotinamide Riboside (NR) — Niagen Bioscience / Dr. Charles Brenner H2H 241 IRA PRICE TRANSCRIPT Tru Niagen https://www.truniagen.com/pages/our-story Oura Ring Sleep Tracking — Oura Health H2H 241 IRA PRICE TRANSCRIPT Oura Support https://support.ouraring.com/hc/en-us/articles/11752397946003-Sleep-Stages Show Notes 00:00 Welcome to the Hart2Heart Podcast 02:04 Peptides Are Everywhere 04:01 GLP-1s Disrupt Weight Loss 08:02 Metformin Longevity Debate 10:41 Doctors Handling Unapproved GLPs 17:17 Patient Power And Education 21:31 Misinformation And Collaboration 25:02 Canadian Drug Policy Overhaul 31:37 Fentanyl Lacing Medetomidine 36:23 Why Healthcare Is Failing 41:01 ER Burnout And Wellness 43:17 Physician Self Care 43:39 Residency Grind Reality 44:23 Fixing Resident Hours 45:34 ER Career Longevity 47:05 Private Healthcare Debate 51:07 Immigration System Strain 53:24 CBD Hype vs Evidence 56:53 CBD Dosing and Cost 01:00:39 Buspirone and Psychedelics 01:08:24 Underrated Cannabinoids 01:12:54 Cannabis Sleep and REM 01:19:03 Cannabis Risks and Alcohol 01:24:47 Closing Thoughts The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of...
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    1 ora e 25 min
  • #239 Oral Peptides: How They Work Without Entering the Bloodstream

    #239 Oral Peptides: How They Work Without Entering the Bloodstream
    Sep 24 2026
    Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can act in intestinal cells without entering circulation and that carnosine is another PEPT1-absorbed example. He outlines multiple local mechanisms (acting in the gut lumen, on the enterocyte surface, inside enterocytes, and in nearby gut tissue) and contrasts these with systemic absorption examples like semaglutide formulated with SNAC (only 0.4–1% reaches blood yet remains effective) and cyclosporine's unusual properties. He notes exceptions like glutathione and discusses theories for BPC-157's oral effects, emphasizing regulated products and upcoming discussion on GLP-1s and obesity with Dr. Spencer Nadolsky. LINZESS (Linaclotide) Prescribing Information — DailyMed, U.S. National Library of Medicine (dailymed.nlm.nih.gov) https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=linaclotide PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation — Gastroenterology / PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/18061177/ The Oligopeptide Transporter PEPT1 in Human Intestine — PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/9207295/ Oral Semaglutide (RYBELSUS) Prescribing Information — Novo Nordisk / DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98 Transcellular Stomach Absorption of Oral Semaglutide With SNAC — Science Translational Medicine / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/30429357/ BPC-157 Oral Administration and Gastrointestinal Healing Research — University of Zagreb / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/18818478/ Cyclosporine Oral Prescribing Information — DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfca7088-fe93-abb9-3ec3-e6f5710a69c6 Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:52 Oral Peptides Mythbusting 02:37 Protein Digestion Basics 03:31 PEPT1 Absorption Pathway 04:39 KPV and Carnosine Examples 06:12 Glutathione Exception 07:38 Garden Hose Local Actions 08:26 Linaclotide IBS Mechanism 09:37 Four Local Action Sites 11:25 SNAC Enables Blood Levels 13:26 Cyclosporine Oral Exception 14:35 Other Minor Pathways 15:43 BPC 157 Oral Mystery 18:10 Wrap Up and Safety Notes 19:57 Closing and Next Episode The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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    20 min
  • #240 Dr. Spencer Nadolsky on Repatha, ApoB Targets, and What Actually Matters in Lipidology

    #240 Dr. Spencer Nadolsky on Repatha, ApoB Targets, and What Actually Matters in Lipidology
    Oct 1 2026
    Dr. Mike Hart sits down with lipidologist Dr. Spencer Nadolsky for a practical discussion on cardiovascular prevention, cholesterol management, and metabolic health. They break down how to interpret ApoB, LDL, HDL, triglycerides, and Lp(a), when cholesterol-lowering medications may make sense, and why long-term exposure matters when thinking about heart disease risk. The conversation also explores statins, PCSK9 inhibitors, plaque progression, supplements, insulin resistance, and the evolving role of GLP-1 medications in obesity treatment and long-term cardiometabolic health. Dr. Spencer Nadolsky is a physician specializing in obesity medicine, lipidology, and cardiometabolic health, with a strong focus on preventing chronic disease before it develops. His approach combines evidence-based medicine with individualized risk assessment, helping patients make sense of cholesterol, metabolic health, body weight, medications, and lifestyle without relying on one-size-fits-all recommendations. Known for translating complex medical research into practical guidance, he emphasizes sustainable health decisions, meaningful clinical outcomes, and finding the balance between being proactive about longevity and becoming overly consumed by it. SAMSON Trial: Statin, Placebo, and No Treatment — James P. Howard et al. / Imperial College London https://pubmed.ncbi.nlm.nih.gov/34531021/ Multi-Ethnic Study of Atherosclerosis (MESA) — National Heart, Lung, and Blood Institute / NIH https://www.nhlbi.nih.gov/science/multi-ethnic-study-atherosclerosis-mesa Framingham Heart Study Offspring Cohort — National Heart, Lung, and Blood Institute / BioLINCC https://biolincc.nhlbi.nih.gov/studies/framoffspring/ Repatha (Evolocumab) — Amgen https://www.repatha.com/resources-and-support Ezetimibe — Mark Cuban Cost Plus Drug Company https://www.costplusdrugs.com/medications/ezetimibe-10mg-tablet/ Rosuvastatin — Mark Cuban Cost Plus Drug Company https://www.costplusdrugs.com/medications/rosuvastatin-10mg-tablet/ Psyllium Fiber / Metamucil — Procter & Gamble / Metamucil https://www.metamucil.com/en-us/articles/psyllium-fiber/psyllium-fiber-in-metamucil Docs Who Lift Podcast — Dr. Spencer Nadolsky & Dr. Karl Nadolsky https://docswholift.com/podcast/ Vineyard — Dr. Spencer Nadolsky https://joinvineyard.com/ Dr. Spencer Nadolsky on Instagram — Dr. Spencer Nadolsky https://www.instagram.com/drnadolsky/ Dr. Spencer Nadolsky on X — Dr. Spencer Nadolsky https://x.com/DrNadolsky Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:29 Reconnecting And Lipids Focus 00:46 Why Switch To Repatha 02:42 Diet Limits And ApoB Goals 04:03 Ezetimibe And Statin Rationale 05:07 Family History Wake Up Call 06:26 Nocebo And Cleaner PCSK9 10:31 Lp Little A Not A Factor 11:47 Oura Ring And Biohacker Stress 13:33 Dropping Pitavastatin And CoQ10 17:20 Bempedoic Acid And Combo Therapy 20:18 LDL ApoB Discordance Explained 23:37 How Low Is Too Low 26:10 Optimal Targets And When To Start 29:13 Can Ultra Low Prevent Plaque 31:09 Why People Ignore Cholesterol 32:23 Can Plaque Regress 33:16 Vitamin K2 Reality Check 34:00 Mechanisms vs Outcomes 34:58 Lp(a) Drug Disappointment 37:08 How to Use Lp(a) 40:23 HDL Myths Explained 43:11 Triglycerides and Insulin 45:35 Oxidized LDL and NMR 47:33 Supplements That Matter 48:51 Berberine Benefits and Risks 51:50 GLP-1 Stacking Debate 56:41 Microdosing and Plateaus 59:34 Longevity and Alcohol Effects 01:00:36 Future of Anti Obesity Drugs 01:02:00 Wrap Up and Where to Find The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart ...
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    1 ora e 3 min
  • #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati

    #238 The Science of Hormones: Birth Control, HRT, and Thyroid with Dr. Masghati
    Sep 17 2026
    In this episode, Dr. Mike Hart and OB-GYN Dr. Salome Masghati examine how common hormone interventions can affect women far beyond pregnancy prevention or symptom relief. They discuss the risks and tradeoffs of different birth control options, possible effects on mood, libido, testosterone, and attraction, and why individual responses can vary significantly. The conversation then explores when to consider HRT, the roles of estrogen, progesterone, and testosterone, thyroid testing beyond TSH, and how shifting hormones may contribute to mast cell symptoms during perimenopause. The episode provides a practical framework for making more informed and personalized decisions about hormone care. Dr. Salome Masghati is a board-certified OB-GYN and functional gynecologist whose work focuses on individualized hormone care for women throughout their reproductive years, perimenopause, and menopause. Her approach combines symptoms, menstrual patterns, comprehensive laboratory testing, metabolic markers, and treatment response to understand each patient's complete health picture rather than relying on a single test or standardized protocol. She works with bioidentical and rhythmic hormone strategies, thyroid care, sexual wellness, and root-cause assessment, emphasizing informed choices, careful monitoring, and helping patients move beyond temporary symptom control toward better long-term health and function. Dr. Salome Masghati Official Website — Dr. Salome Masghati, Precision Gynecology https://drsalomemasghati.com/ Dr. Salome Masghati on Instagram — Dr. Salome Masghati https://www.instagram.com/drsalomemasghatimd/ This Is Your Brain on Birth Control — Dr. Sarah E. Hill https://www.sarahehill.com/books/your-brain-on-birth-control/ Women's Health Initiative — National Heart, Lung, and Blood Institute, NIH https://www.nhlbi.nih.gov/science/womens-health-initiative-whi 2022 Hormone Therapy Position Statement — The North American Menopause Society https://menopause.org/wp-content/uploads/professional/nams-2022-hormone-therapy-position-statement.pdf Mortality Associated With Hormone Replacement Therapy — Shelley R. Salpeter et al. https://pubmed.ncbi.nlm.nih.gov/15209595/ Oral Contraceptives, SHBG, and Androgen Levels — Claudia Panzer et al. https://pubmed.ncbi.nlm.nih.gov/16409223/ Hormonal Contraceptive Discontinuation and Relationship Satisfaction — V. Michelle Russell et al. https://pubmed.ncbi.nlm.nih.gov/25404285/ Progestogen Use and Intracranial Meningioma Risk — Léa Hoisnard et al., The BMJ https://www.bmj.com/content/384/bmj-2023-078078 Physiologic Hormone Restoration Therapy — Women's Hormone Network https://womenshormonenetwork.org/traditional-versus-pr/ GlycanAge Biological Age Test — GlycanAge https://glycanage.com/ Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:00 Birth Control Safety Overview 02:07 SHBG Testosterone Libido Risks 04:19 SSRIs And Sexual Side Effects 05:26 Depo Shot Meningioma Concerns 09:07 Choosing Alternatives And Counseling 12:40 Attraction Changes And Partner Choice 15:20 Doctor Personal Story Coming Off 19:15 Menopause HRT Fear And WHI 22:00 Estrogen Window For Heart Brain 24:12 HRT Longevity And Start Age 30:41 Testosterone For Women Benefits 33:06 Rhythmic Hormone Dosing Explained 35:30 Cycle-Based GLP-1 Dosing 37:12 Evidence for Rhythmic HRT 39:32 Hormone Cycling and Cancer Risk 41:13 Why Most Doctors Don't 42:58 Libido and Orgasm Tools 46:59 Thyroid Labs Beyond TSH 50:26 Thyroid Antibodies Strategy 54:59 Staying on HRT for Life 58:21 Bioidentical Hormone Choices 01:00:53 Progesterone Delivery Debate 01:02:50 Mast Cell Activation Explained 01:07:28 Wrap-Up and Where to Follow The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that...
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    1 ora e 10 min
  • #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening

    #237 Oral Health, Blood Pressure, and Better Hygiene: Dr. Eilon on Toothpaste, Mouthwash, and Whitening
    Sep 10 2026

    Dr. Mike Hart sits down with Dr. Ilon Choai to unpack everyday dental habits and the connection between oral and overall health. They discuss choosing toothpaste, fluoride versus nano-hydroxyapatite, and how mouthwash may affect the oral microbiome. Dr. Choai shares his approach to brushing, flossing, tongue scraping, and managing dietary acid exposure, while explaining teeth-whitening options, addressing root canal concerns, and outlining what to consider before getting veneers.

    Dr. Ilon Choai is a practicing dentist, the creator of NOBS oral care products, and a co-host of Down to Health. His work emphasizes preventive dentistry, patient education, and helping people build habits they can maintain beyond the dental chair. Known online as @thenobsdentist, he encourages informed conversations about dental products and treatment choices. His approach combines clinical care with an interest in moving dentistry beyond "drill, fill, and bill" toward a more integrated role in whole-body health.

    NOBS Toothpaste Tablets — NOBS
    https://nobsroutines.com/products/nobs-toothpaste-tablets

    NOBS Herbal Mouthwash — NOBS
    https://nobsroutines.com/products/nobs-herbal-mouthwash

    Atomic Habits — James Clear
    https://jamesclear.com/atomic-habits

    Root Canal Discussion: "Is This Procedure Really Causing Cancer?" — Down to Health, featuring Dr. Valerie Kanter
    https://music.youtube.com/podcast/Vn-SH7qbvkw

    Relative Dentin Abrasivity (RDA) Explained — American Dental Association
    https://www.ada.org/resources/ada-library/oral-health-topics/toothpastes

    Show Notes

    00:00 Welcome to the Hart2Heart Podcast

    01:08 Why Oral Health Matters

    04:35 Choosing The Right Toothpaste

    09:15 Why Whitening Toothpaste Fails

    13:58 Key Toothpaste Ingredients

    22:49 Hydroxyapatite And Fluoride

    28:31 Electric Brushes And Technique

    30:56 Waterpik Versus Flossing

    34:32 Mouthwash Myths And Safer Picks

    40:24 Acidic Mouthwash Risks

    41:00 Tongue Scraping Basics

    44:21 Nighttime Snacking Rules

    45:48 Carbonated Drinks and pH

    47:43 Mouth Breathing and Dry Mouth

    50:39 Teeth Whitening Science

    54:00 Whitening Options and Longevity

    01:00:25 Dental Cleaning Ingredients

    01:01:54 Fillings Materials and Safety

    01:06:53 Root Canals Mythbusting

    01:11:34 Veneers Hype and Downsides

    01:16:37 Gum Disease and Heart Health

    01:20:19 Ideal Oral Hygiene Plan

    01:24:10 Where to Find NOBS

    The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance.

    This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary.

    Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being.

    Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary

    (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as

    Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen).

    If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.

    Connect with Dr. Mike Hart

    Instagram: @drmikehart
    Twitter: @drmikehart
    Facebook: @drmikehart
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    1 ora e 25 min
  • #236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims

    #236 The Cannabis Cure Controversy: Lee Whitley's Bold Claims
    Sep 3 2026
    In this episode, Dr. Mike Hart sits down with Lee Whitley and physician Dr. Ira Price for a wide-ranging discussion about Lee's proprietary cannabis formulation and the extraordinary cancer-treatment claims surrounding it. Lee shares his own experience with stage IV squamous cell throat cancer, patient case stories, oral and injectable applications, dosing, and alleged pharmaceutical acquisition offers, while Dr. Price separates what he has personally observed from what has yet to be established through rigorous research. The conversation explores cannabinoids, THC, CBD, terpenes, chemotherapy and radiation, pathology and imaging, the limitations of anecdotal evidence, and the regulatory, funding, and data-access barriers standing between individual case reports and credible clinical trials. Lee Whitley is an entrepreneur and the creator of Lee's Oil and Lee Helps, a cannabis-based project that grew out of his personal experience with cancer and his years of developing and refining a proprietary cannabis formulation. He has since become an outspoken advocate for studying the results he says he has observed through formal clinical research. Dr. Ira Price is a physician with nearly two decades of experience prescribing cannabinoids and researching medical cannabis, including published work on cannabis for opioid substitution and years of lecturing internationally on cannabinoid medicine. Together, Whitley and Dr. Price bring two very different perspectives to the conversation—one shaped by personal experience and unconventional experimentation, and the other by clinical practice, scientific skepticism, and a focus on evidence, regulation, and properly designed trials. Lee Helps / Lee's Oil — Lee Whitley https://leehelps.com/ Cannabis for Opioid Substitution Trial (COST) — Dr. Ira Price / Cannabis Research Associates https://clinicaltrials.gov/study/NCT03859089 Cannabis Research Licensing — Health Canada https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/industry-licensees-applicants/research-licensing-application.html Clinical Trials With Cannabis — Health Canada https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/announcements/notice-clarification-requirements-conducting-clinical-trials-cannabis.html Human Health Therapeutics Research Centre — National Research Council Canada https://www.nrc.canada.ca/en/research-development/research-collaboration/research-centres/human-health-therapeutics-research-centre Prescribing Drugs Policy — College of Physicians and Surgeons of Ontario (CPSO) https://www.cpso.on.ca/physicians/policies-guidance/policies/prescribing-drugs 4-Year-Old Cancer Case With 132 Tumors — Lee Whitley / Shit My Dad Taught Me https://www.iheart.com/podcast/1323-shit-my-dad-taught-me-264023145/episode/ep-22-lee-whitley-286273525/ Lee Helps Cancer & Melanoma Testimonials — Lee Whitley / Lee Helps Oil https://www.leehelpsoil.com/ Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:29 Claimed Cure Rates 01:59 Doctor Skepticism 03:47 Four Year Old Case 06:40 Colon Cancer Testimonial 09:43 Lee Cancer Story 14:28 Injection Timeline 16:00 Formula Breakdown 18:28 Terpenes Explained 21:29 Rick Simpson Comparison 24:52 How It Works 27:43 Chemo Radiation Debate 33:20 Injections Vs Pills 36:42 Research Roadblocks 44:03 Trial Plans Abroad 44:34 30 Women Trial Plan 46:02 Study Design Debate 47:23 Dosing Protocol Details 48:43 Big Pharma Buyout Claims 51:50 Suppression And Threats 55:12 What Happens After Success 57:59 Finding Patients And Reach 59:48 Treating More Than Cancer 01:06:51 How The Plant Was Found 01:13:47 Chemo Radiation Clash 01:17:59 Timeline And Publication 01:20:27 Closing Advice And Wrap The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut ...
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    1 ora e 25 min
  • #235 Dr. Kenealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors

    #235 Dr. Kenealy on Preventing Cancer: Lifestyle, Toxins, Hormones, Fasting, and Screening Beyond Tumors
    Aug 27 2026
    In this episode, Dr. Mike Hart sits down with Dr. Leigh Erin Connealy for a wide-ranging conversation on cancer prevention and the factors she believes influence long-term health. Dr. Connealy shares her perspective on why cancer should be approached as a whole-body problem, exploring the roles of nutrition, metabolic health, environmental toxins, sleep, stress, hormones, and mitochondrial function. They also discuss fasting and ketogenic diets, cancer screening, GLP-1 medications, aspirin, peptides, medicinal mushrooms, IV vitamin C, and other integrative approaches, along with Dr. Connealy's concerns about conventional screening and treatment practices. Throughout the conversation, she emphasizes individualized care and looking beyond a diagnosis to understand the broader conditions affecting each patient. Dr. Leigh Erin Connealy is a medical doctor with four decades of experience who takes a prevention-focused, whole-person approach to health, longevity, and complex chronic disease. Her work spans human optimization through advanced conditions including cancer, dementia, autoimmune disease, and Parkinson's, with an emphasis on identifying and addressing factors that may interfere with the body's ability to function optimally. Her approach was shaped in part by her own health journey after learning that she had been exposed before birth to DES (diethylstilbestrol), which led her to undergo ongoing evaluations at MD Anderson and explore medicine beyond conventional symptom-based care. Over her career, she has incorporated individualized laboratory assessment, natural hormones, nutrition, peptides, and other integrative strategies while emphasizing what she describes as "creating health" rather than simply treating a diagnosis. [The Cancer Revolution] — Leigh Erin Connealy, MD / Hachette Book Group https://www.hachettebookgroup.com/titles/leigh-erin-connealy/the-cancer-revolution/9780306836688/ [Be Perfectly Healthy] — Leigh Erin Connealy, MD / Perfectly Healthy https://perfectlyhealthy.com/products/be-perfectly-healthy-1 [Celluverse Podcast] — Dr. Leigh Erin Connealy, Alannah Connealy & Jess Donovan https://podcasts.apple.com/us/podcast/celluverse/id1836455844 [Dr. Leigh Erin Connealy Instagram — @connealymd] — Leigh Erin Connealy, MD https://www.instagram.com/connealymd/ [Cologuard Plus] — Exact Sciences Corporation https://www.cologuard.com/resources [QTI Breast Acoustic CT Scanner] — QT Imaging Holdings, Inc. https://www.qtimaging.com/breast-acoustic-ct-scanner/ [UT MD Anderson Cancer Center] — The University of Texas MD Anderson Cancer Center https://www.mdanderson.org/ [Eminence Organic Skin Care — Sun Care] — Eminence Organic Skin Care https://eminenceorganics.com/us/face/sun-care [Primally Pure Sunscreen] — Primally Pure https://primallypure.com/pages/sunscreen [COOLA Sunscreen] — COOLA https://coola.com/collections/sunscreen Show Notes 00:00 Welcome to the Hart2Heart Podcast 01:07 Root Cause Medicine 02:29 Is Cancer Preventable 05:42 Biggest Risk Factors 09:51 Toxins And Detox Testing 12:26 Sweating And Detox Baths 00:00 Doctors Not Listening 16:58 Does Sugar Feed Cancer 22:37 Fasting And Keto Strategies 26:05 Mushrooms And Supplements 27:21 Thiamine And Nutrient Gaps 29:35 Hormones And Cancer Risk 35:42 Complete Hormone Panels 38:02 GLP-1s and Cancer Risk 39:18 Daily Aspirin Debate 41:12 Peptides to Avoid 43:20 Russian Peptides Cycling 45:43 Non Toxic Sunscreen Choices 47:14 Deodorants and Aluminum 48:18 AirPods and Brain Health 50:26 Cancer Screening Strategy 54:30 Breast Imaging Options 56:05 Biopsy Spread Concerns 58:09 Why Medicine Misses Prevention 01:01:55 Personal DES Cancer Journey 01:03:10 IV Vitamin C for Cancer 01:04:26 Where to Follow and Book The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is ...
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    1 ora e 6 min