Hart2Heart with Dr. Mike Hart copertina

Hart2Heart with Dr. Mike Hart

Hart2Heart with Dr. Mike Hart

Di: Dr. Mike Hart
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Hart2Heart is the show where Dr. Mike Hart breaks down evidence-based health, longevity, performance, and modern medicine without the fluff. Each episode explores practical, evidence-based strategies for improving your life, including hormone health, peptides, sleep optimization, nutrition, supplements, exercise, sunlight, psychedelics, and smarter medication use. The goal is simple: help you understand what actually works so you can make better decisions for your health. The show also looks at the bigger picture, including how public health policy and politics influence personal well-being, and what you can do to take back control. If you want clear, actionable, no-BS conversations about living healthier, performing better, and thinking for yourself, this podcast is for you.Copyright 2023 | Upfire Digital LLC Disturbo fisico e malattia Igiene e vita sana
Episodi
  • #242 Hair Loss Treatments: Minoxidil, Topical Dutasteride, Microneedling, and PRP/Placental Exosomes

    #242 Hair Loss Treatments: Minoxidil, Topical Dutasteride, Microneedling, and PRP/Placental Exosomes
    Oct 15 2026
    In this solo Hart2Heart Podcast episode (focused on male androgenetic alopecia), Dr. Mike Hart reviews hair-loss treatments, emphasizing that regrowth is harder if follicles are gone after 12–18 months. He highlights minoxidil (topical or oral), noting similar efficacy between 2.5 mg and 5 mg oral dosing, comparable results between oral 5 mg and topical 5% twice daily, and that adding 0.01% tretinoin may allow once-daily topical use; combining oral and topical is unstudied but not necessarily dangerous. He advises avoiding systemic DHT blockers due to side effects, favoring 0.05% topical dutasteride for minimal blood DHT reduction, and recommends weekly microneedling (~0.75 mm) without applying products immediately after. As growth-factor adjuncts, he prioritizes PRP or placental exosomes, discusses limited evidence for ketoconazole shampoo and copper peptides, warns DHT-derived anabolic steroids won't be helped by dutasteride, and reviews emerging anti-androgen options and their systemic-risk concerns. Oral vs. Topical Minoxidil for Hair Loss — Mariana Alvares Penha et al., JAMA Dermatology https://pubmed.ncbi.nlm.nih.gov/38598226/ Minoxidil and Tretinoin Combination Treatment — Hyo Seung Shin et al., American Journal of Clinical Dermatology https://pubmed.ncbi.nlm.nih.gov/17902730/ Topical Dutasteride 0.05% for Male Pattern Hair Loss — Veerendra Kumar Panuganti et al., Cureus https://pubmed.ncbi.nlm.nih.gov/40909044/ Ketoconazole 2% Shampoo for Hair Loss (Nizoral) — C. Piérard-Franchimont et al., Dermatology https://pubmed.ncbi.nlm.nih.gov/9669136/ Microneedling for Hair Regrowth — Rachita Dhurat et al., International Journal of Trichology https://pubmed.ncbi.nlm.nih.gov/23960389/ Platelet-Rich Plasma (PRP) for Hair Loss — C. Donnelly et al., Journal of Cosmetic Dermatology https://pubmed.ncbi.nlm.nih.gov/38284294/ Exosomes for Hair Regeneration — Mohammed A. Al Ameer et al., Clinical, Cosmetic and Investigational Dermatology https://pubmed.ncbi.nlm.nih.gov/40955427/ AHK-Cu Copper Peptide and Hair Growth Research — Hyun Keol Pyo et al., Archives of Pharmacal Research https://pubmed.ncbi.nlm.nih.gov/17703734/ Emerging Hair Loss Treatments: Clascoterone and Pyrilutamide — Shivali Devjani et al., Drugs https://pubmed.ncbi.nlm.nih.gov/37166619/ GT20029: Emerging Hair Loss Treatment — Ruiming Hu et al., Journal of Dermatological Treatment https://pubmed.ncbi.nlm.nih.gov/41328006/ Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:34 Podcast Intro and Scope 01:56 Realistic Regrowth Expectations 02:47 Minoxidil Dosing and Use 07:23 Topical Dutasteride Strategy 11:26 Adjunct Shampoo Option 12:16 Microneedling Done Right 14:55 PRP and Exosomes Boosters 16:47 Copper Peptides Hype Check 19:05 Other Add Ons and Big Four Recap 20:16 Steroids and DHT Reality 22:32 Future Anti Androgen Treatments 28:12 Wrap Up and Final Takeaways The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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    30 min
  • #241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price

    #241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price
    Oct 8 2026
    Dr. Mike Hart and Dr. Ira Price explore how medicine is adapting as patients gain greater access to emerging treatments, health information, and tools once limited to physicians. They discuss unapproved peptides and GLP-1 drugs, the growing shift toward personalized and patient-centered care, and the challenges doctors face when evidence and regulation lag behind real-world use. The conversation expands into Canada's opioid crisis, drug decriminalization, fentanyl and medetomidine contamination, emergency-room strain, physician burnout, and broader problems within the Canadian healthcare system. They also examine medical cannabis, CBD and lesser-known cannabinoids, psychedelic medicine, sleep, longevity, and the importance of balancing individual choice with evidence, clinical judgment, and responsible medical guidance. Dr. Ira Price is an emergency physician, sports medicine specialist, and longtime cannabinoid-medicine practitioner whose work sits at the intersection of acute care, emerging therapeutics, and patient-centered medicine. Over nearly two decades working with cannabinoids and years on the front lines of emergency care, he has developed a strong focus on helping patients navigate treatments that often move faster than traditional medical guidelines. His approach emphasizes collaboration rather than gatekeeping, encouraging physicians to remain lifelong learners while helping patients critically evaluate evidence, understand risks and benefits, and make more informed decisions about their health. He brings a practical perspective shaped by emergency medicine, sports medicine, cannabinoid research and clinical practice, and firsthand experience with the evolving challenges facing modern healthcare. Medical Cannabis or Cannabinoids for Chronic Non-Cancer and Cancer Related Pain — Li Wang et al., including Dr. Ira Price / The BMJ H2H 241 IRA PRICE TRANSCRIPT BMJ https://www.bmj.com/content/374/bmj.n1034 Therapeutic Potential of Cannabidiol (CBD) in Anxiety Disorders: A Systematic Review and Meta-Analysis — Kevin Han, Jia-Yu Wang, Peng-Yun Wang & Yue-Chu-Han Peng H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/38924898/ EPIDIOLEX (Cannabidiol) — Jazz Pharmaceuticals H2H 241 IRA PRICE TRANSCRIPT EPIDIOLEX.com https://www.epidiolex.com/what-is-epidiolex Acute Effects of Cannabigerol on Anxiety, Stress, and Mood — Carrie Cuttler, Amanda Stueber, Ziva D. Cooper & Ethan Russo / Scientific Reports H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/39003387/ CBD and THCV in Patients With Type 2 Diabetes — Khalid A. Jadoon et al. / Diabetes Care H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/27573936/ Dependence Potential and Acute Toxicity of Psychoactive Substances — Robert S. Gable / American Journal of Drug and Alcohol Abuse H2H 241 IRA PRICE TRANSCRIPT PubMed https://pubmed.ncbi.nlm.nih.gov/8213692/ Tru Niagen / Nicotinamide Riboside (NR) — Niagen Bioscience / Dr. Charles Brenner H2H 241 IRA PRICE TRANSCRIPT Tru Niagen https://www.truniagen.com/pages/our-story Oura Ring Sleep Tracking — Oura Health H2H 241 IRA PRICE TRANSCRIPT Oura Support https://support.ouraring.com/hc/en-us/articles/11752397946003-Sleep-Stages Show Notes 00:00 Welcome to the Hart2Heart Podcast 02:04 Peptides Are Everywhere 04:01 GLP-1s Disrupt Weight Loss 08:02 Metformin Longevity Debate 10:41 Doctors Handling Unapproved GLPs 17:17 Patient Power And Education 21:31 Misinformation And Collaboration 25:02 Canadian Drug Policy Overhaul 31:37 Fentanyl Lacing Medetomidine 36:23 Why Healthcare Is Failing 41:01 ER Burnout And Wellness 43:17 Physician Self Care 43:39 Residency Grind Reality 44:23 Fixing Resident Hours 45:34 ER Career Longevity 47:05 Private Healthcare Debate 51:07 Immigration System Strain 53:24 CBD Hype vs Evidence 56:53 CBD Dosing and Cost 01:00:39 Buspirone and Psychedelics 01:08:24 Underrated Cannabinoids 01:12:54 Cannabis Sleep and REM 01:19:03 Cannabis Risks and Alcohol 01:24:47 Closing Thoughts The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of...
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    1 ora e 25 min
  • #239 Oral Peptides: How They Work Without Entering the Bloodstream

    #239 Oral Peptides: How They Work Without Entering the Bloodstream
    Sep 24 2026
    Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can act in intestinal cells without entering circulation and that carnosine is another PEPT1-absorbed example. He outlines multiple local mechanisms (acting in the gut lumen, on the enterocyte surface, inside enterocytes, and in nearby gut tissue) and contrasts these with systemic absorption examples like semaglutide formulated with SNAC (only 0.4–1% reaches blood yet remains effective) and cyclosporine's unusual properties. He notes exceptions like glutathione and discusses theories for BPC-157's oral effects, emphasizing regulated products and upcoming discussion on GLP-1s and obesity with Dr. Spencer Nadolsky. LINZESS (Linaclotide) Prescribing Information — DailyMed, U.S. National Library of Medicine (dailymed.nlm.nih.gov) https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=linaclotide PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation — Gastroenterology / PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/18061177/ The Oligopeptide Transporter PEPT1 in Human Intestine — PubMed, U.S. National Library of Medicine (PubMed) https://pubmed.ncbi.nlm.nih.gov/9207295/ Oral Semaglutide (RYBELSUS) Prescribing Information — Novo Nordisk / DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98 Transcellular Stomach Absorption of Oral Semaglutide With SNAC — Science Translational Medicine / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/30429357/ BPC-157 Oral Administration and Gastrointestinal Healing Research — University of Zagreb / PubMed (PubMed) https://pubmed.ncbi.nlm.nih.gov/18818478/ Cyclosporine Oral Prescribing Information — DailyMed, U.S. National Library of Medicine (DailyMed) https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bfca7088-fe93-abb9-3ec3-e6f5710a69c6 Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:52 Oral Peptides Mythbusting 02:37 Protein Digestion Basics 03:31 PEPT1 Absorption Pathway 04:39 KPV and Carnosine Examples 06:12 Glutathione Exception 07:38 Garden Hose Local Actions 08:26 Linaclotide IBS Mechanism 09:37 Four Local Action Sites 11:25 SNAC Enables Blood Levels 13:26 Cyclosporine Oral Exception 14:35 Other Minor Pathways 15:43 BPC 157 Oral Mystery 18:10 Wrap Up and Safety Notes 19:57 Closing and Next Episode The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
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    20 min
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