Phoebe Ashley-Norman of The Lancet Microbe speaks to Amber Barton about the neglected tropical disease, yaws. Efforts to eradicate yaws were first made in the 1950s through a WHO and UNICEF campaign that reduced yaws prevalence by 90%, but it remained endemic in some regions.

Global efforts involving the mass drug administration of azithromycin continue in pursuit of the WHO 2030 yaws eradication goal. In this podcast, Amber discusses how genomic epidemiology can be used to investigate the effectiveness of yaws eradication strategies, detect sublineages of yaws at higher resolution, and improve our understanding of macrolide resistance.

Click here to read the full article: https://www.thelancet.com/journals/lanmic/article/piiS2666-5247(25)00157-0/fulltext

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Elena Dalla Vecchia of The Lancet Microbe speaks to Dr Britt Koskella about bacteriophages and phageome, their role in modulating the bacteriome, their potential use as signatures of microbiome health and dysbiosis, and hence, indirectly, as markers of host health and disease status.

From an ecological perspective, parasites (such as bacteriophages) are key drivers of the evolution of their hosts (bacteria), and so one might expect to find diverse and rich bacteriomes in the presence of a highly diverse and thriving microbiome: Britt has been exploring this possibility and discusses it in this episode.

Click here to read the full article: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00124-7/fulltext

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Rebecca Barksby of The Lancet Microbe speaks to Dr Christian Malaka and Dr Livia Patrono on mpox in the Central African Republic and how researchers are using genomic surveillance to provide insights into the epidemiology of the virus.

Read the full article: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00101-6/fulltext

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Elena Dalla Vecchia talks with Dr Sam Lipworth and Prof Nicole Stoesser about the challenges and variability in genotypic predictions of antimicrobial resistance in Escherichia coli, about which they have published two papers in The Lancet Microbe: “Exploring uncatalogued genetic variation in antimicrobial resistance gene families in Escherichia coli: an observational analysis” and “Estimating the association of antimicrobial resistance genes with minimum inhibitory concentration in Escherichia coli, an observational study”.

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Rebecca Barksby of The Lancet Microbe speaks to Dr Anastasia Theodosiou about performing a controlled human infection study in pregnant women investigating mother-to-infant transmission of Neisseria lactamica.

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https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00254-4/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanmic

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Elena Dalla Vecchia of The Lancet Microbe speaks to Susan Meiring, Vanessa Quan, and Nelesh Govender about bloodstream infections in neonates at lower-tier South African hospitals.

Read the full paper, Pathogen aetiology and risk factors for death among neonates with bloodstream infections at lower-tier South African hospitals: a cross-sectional study, at https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00257-X/fulltext

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Rebecca Barksby of The Lancet Microbe speaks to Professor Laurence Armand-Lefevre and Professor Luc Hervé Samison about implementing the WHO Tricycle Protocol in Madagascar for the surveillance of extended-spectrum β-lactamase producing Escherichia coli in humans, chickens, and the environment.

Read the full article:
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00228-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinm

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Elena Dalla Vecchia of The Lancet Microbe speaks to Dr Zoe Dyson and Dr Philip Ashton about the genomic characterisation of population diversity, antimicrobial resistance profiles, and transmission patterns of Salmonella enterica serotypes Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi.

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