In this episode of the Incubator podcast, hosts David McCulley and Betsy Crouch engage with Dr. Tippi MacKenzie, a leading figure in fetal surgery and stem cell research. The conversation explores Dr. MacKenzie's journey from clinician to scientist, the challenges and innovations in fetal surgery, and the future of prenatal therapies. They discuss the importance of collaboration in research, the role of clinical trials, and the impact of genetic therapies on treating fetal conditions. The episode highlights the intersection of clinical practice and research, emphasizing the need for responsible advancements in medical science.

In this episode of At the Bench, Misty Good and David McCulley interview Dr. Bernard Thébaud, a neonatologist and leader in lung and pulmonary vascular developmental biology and regenerative medicine. The conversation explores Dr. Thebaud’s journey into research, the importance of mentorship, and the challenges of translating research into clinical practice. They discuss the significance of recognizing opportunities, navigating critical feedback, and the promising mechanisms in regenerative medicine that could enhance lung repair in preterm infants. Dr. Thébaud discusses the innovative use of mesenchymal stromal cells in lung therapy for neonatal patients. He shares insights on the unexpected findings from his research, the potential of umbilical cord-derived cells, and the future of neonatal lung regenerative medicine. The conversation also touches on the importance of mentorship, resilience in research, and fostering a positive lab environment.

In this episode of At the Bench, Betsy Crouch and David McCulley engage in a thought-provoking conversation with Dr. Eleanor Molloy, a neonatologist and physician scientist. They explore Eleanor's journey in neonatology, the importance of inflammation in neonatal health, and the challenges and rewards of conducting research in this field. The discussion also highlights the significance of collaboration, both within research teams and with parents, to enhance clinical practice and improve outcomes for neonates. Eleanor shares insights on the role of biomarkers, the impact of sex differences in research, and the necessity of international collaboration in pediatric research. The episode concludes with reflections on the balance between clinical work and research, the importance of community in academia, and the need for a rallying call to inspire the next generation of clinician scientists.

In this episode of At the Bench, hosts Dr. Misty Good and Dr. Betsy Crouch sit down with Dr. AnneMarie Stroustrup, Chair of Pediatrics at Zucker School of Medicine, Physician-in-Chief at Cohen Children’s Medical Center, and senior vice president of the pediatric service line at Northwell Health.

Dr. Stroustrup reflects on her path from early work in biotechnology to training as a neonatologist and physician scientist. She shares how volunteer experiences in an under-resourced emergency department shaped her decision to pursue medicine, and how her MPH in epidemiology provided the tools to investigate critical questions about fetal and neonatal exposures.

The conversation highlights her research on environmental chemicals—particularly phthalates—and their links to outcomes such as bronchopulmonary dysplasia, work within the NIH ECHO program, and the importance of large-scale, collaborative science. Dr. Stroustrup also discusses the persistence required in research, navigating funding rejections, and translating epidemiologic findings back to bench models.

The discussion concludes with her insights on leadership in neonatology, from directing divisions and fellowships to now serving as chair, balancing research, clinical duties, and family life while advocating for sustainable staffing models in pediatrics.

In this episode of At-the-Bench, hosts David McCulley and Misty Good interview Dr. Jennifer Wambach, a neonatologist and researcher specializing in rare neonatal lung diseases. Dr. Wambach shares her journey into neonatology, her research on genetic lung diseases, and the importance of mentorship in developing future physician-scientists. The conversation also covers the Undiagnosed Diseases Network, current research on genetic lung diseases including ABCA3 deficiency, and the challenges faced in rare disease research. Dr. Wambach emphasizes the need for resilience and adaptability in scientific careers, offering valuable advice for early-career investigators.

In this episode, David McCulley and Betsy Crouch interview Dr. Benjamin Fensterheim, a neonatology physician scientist, who shares his journey through medical training, the inspiration behind his immunology research, and the importance of bridging the gap between basic science and clinical neonatology. The conversation delves into the challenges faced by physician scientists, the evolving landscape of neonatal care, and the need for innovative therapies in the NICU. Dr. Fensterheim emphasizes the significance of community and mentorship in supporting early-career researchers and advocates for the value of science in improving healthcare outcomes for infants.

In this episode of At the Bench, Drs. Misty Good and Betsy Crouch welcome Dr. Amélie Collins, an R01-funded neonatologist and associate professor at Cincinnati Children’s. A classically trained immunologist turned hematopoietic stem cell biologist, Dr. Collins shares her journey from philosophy major at the University of Chicago to leading a research program focused on fetal myelopoiesis in the context of maternal inflammation.

She discusses her training path through MD/PhD at NYU, her formative time in the labs of Dan Littman and Emmanuelle Passegué, and the critical mentorship moments that shaped her career. Dr. Collins offers an honest look at the challenges and joys of long training, pivoting research directions, and starting an independent lab. She reflects on the intersection of science and clinical care, grant writing as a creative exercise, and the importance of celebrating effort and submission, not just success.

We also dive into her Cell paper on the extrinsic regulation of emergency myelopoiesis in the fetus, the role of maternal IL-10, and how her lab is exploring how hematopoietic stem cells mature and retain memory of early-life exposures.
Dr. Collins leaves listeners with powerful advice: “Do it because you love it. This career demands a lot, including your time, energy, and weekends. But if you love it, it’s worth it.”

In this episode of At The Bench, Drs. Misty Good and Betsy Crouch speak with Dr. Stephanie Gaw, a maternal-fetal medicine specialist at UCSF, about her path to becoming a physician-scientist and her translational research on placental infections. Dr. Gaw shares how early lab experiences, time in the Peace Corps, and a pivot from infectious disease to OB-GYN shaped her focus on maternal immunity and global health.

The conversation covers Dr. Gaw’s work on sepsis in pregnancy, COVID-19 and RSV vaccine responses, and congenital infections like syphilis. She also discusses her approach to building and managing a large placental biorepository, and the importance of thoughtful sample collection for reliable research outcomes. The episode includes practical insights on balancing clinical duties with research, the benefits of peer mentorship, and how clinical observations can drive lab-based investigation.

This discussion offers a clear look into the realities and rewards of bridging bedside observations with bench research in maternal-fetal medicine. It’s a valuable listen for early-career physician-scientists and anyone interested in the complexities of immunology, placental biology, and perinatal infection.