Episodi

  • Full Body MRI: Who Should (& Should Not) Get One

    Full Body MRI: Who Should (& Should Not) Get One
    Oct 17 2026
    Should you get a full body MRI? Most people decide based on cost. That's the wrong question. Even with unlimited money, for the average person the scan sends roughly 10 people down a path of potential harm for every 1 it potentially helps. But there is a specific group of people where it's worth it, and this video shows you how to find out if you're one of them. In this video, Dr. Quinn Stillson (MD, A4M board-certified in longevity medicine) walks through the actual evidence on whole body MRI screening, the kind sold direct-to-consumer by Prenuvo, Ezra (now Function Health) and others: what a standard scan can and can't see, how likely it is to find something that matters for YOU, the real numbers on incidental findings, biopsies and overdiagnosis, and a step-by-step framework for deciding. No sales pitch, no "it's a scam." Just the data, finding by finding. The result: a three-tier system for who should get one, who shouldn't, and how to do it right if you do. In this video, you'll learn: Why a full body MRI is NOT the same as an MRI of every body part (and what that costs you in detail) The cancers it actually sees well vs. the ones it's nearly blind to (colon, breast, lung, prostate) Which sequences a scan needs (T1, T2, STIR, DWI, Dixon) and the tell for a scan that's skipping them The add-ons: brain MRA, FLAIR, volumetrics, cardiac strain, body composition. Which are worth it The real cancer detection rate (1.57%) and how your genes, family history and medical history change it The non-cancer findings that can change what you do: fatty liver, AAA, spine fractures, pancreatic cysts, brain aneurysms, meningiomas Tracking data (brain volume, muscle quality, organ volumes): what the scan adds over DEXA and bloodwork Why ~30% of people get an indeterminate finding and only 2-4% have something serious The hidden costs: anxiety, extra imaging, radiation, biopsies, surgery for benign findings Overdiagnosis: why 42-58% of screen-detected kidney cancers were never going to hurt anyone The decision framework: elevated AND spread-out risk, the tracking gate, age, and anxiety The three tiers (and the "do not get one" list) How to do it right: the 3 questions to ask the provider, ONCO-RADS, and planning repeat scans Best for: – Anyone considering a Prenuvo, Ezra or other direct-to-consumer full body MRI – People with a family history or genetic risk trying to figure out if the scan actually helps them – Longevity enthusiasts who want the tracking data and need to know if it's worth it – Anyone who already got one and is staring at an "indeterminate finding" – Clinicians who want the numbers, not the marketing Timestamps 00:00 Should You Get a Full Body MRI? Why This Is Not a Cost Question 01:51 Full Body vs Dedicated MRI - Why It Sees Less 03:54 Cancers It Detects & Misses 05:38 Other Findings It Detects & Misses (Aneurysms, Cysts, Fractures, Etc) 07:10 Not All Scans Are Equal: Sequences & Skimping 09:11 Add-Ons - Body Comp, Brain MRA & Volumetrics, Heart Strain, Organ Aging 11:12 Cancer Detection Rate in YOU & Why It's Individualized 12:50 Genes, Family History, & Medical History: What Raises YOUR Odds 15:42 Fatty Liver, AAA & Spine Fractures 18:19 Pancreatic Cysts, Heart Strain & Brain Aneurysms 21:30 Tracking: Muscle Quality, Brain Volume, & Organ Aging 23:28 Risk #1 - The 30% Problem (Indeterminate Findings) 24:54 Anxiety, Extra Imaging, Biopsies & Surgery 28:31 Overdiagnosis - Was the Cancer ACTUALLY Going to Hurt You? 31:26 Should YOU Get One? The 2 Conditions (Elevated AND Spread Out Risks) 35:05 Tracking Data: Worth It? 36:34 Age & Anxiety: The Final 2 Decision Makers 38:02 The 3 Tiers of Use Cases (& Who Should NOT Get One) 40:30 Do It Right, Steps 1-3 - What to Ask, Which Add-Ons, & Results Plan 42:45 Do It Right, Steps 4-5 - Screenings & Repeat Scans Get the FREE Full Body MRI Decision Guide (every risk factor, every number, and the walkthrough from this video): https://www.quinnstillsonmd.com/home#mri-guide Subscribe for weekly videos on peptides, longevity & performance! Medical Disclaimer This video is for educational purposes only and does not constitute medical advice. Imaging and screening decisions should be made with a qualified healthcare provider who knows your personal and family history. Nothing here is a recommendation for or against any specific scan, provider, or treatment. #FullBodyMRI #WholeBodyMRI #MRIScreening #Longevity #CancerScreening #PreventiveMedicine #Biohacking
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    46 min
  • I Ranked Every Way to Build Muscle & Lose Fat - Most Aren't Worth It.

    I Ranked Every Way to Build Muscle & Lose Fat - Most Aren't Worth It.
    Sep 19 2026
    Most people building muscle and losing fat are optimizing the wrong variable. The single fastest studied way to gain muscle adds 13 lbs of lean mass in 10 weeks — but effectiveness alone tells you nothing about whether something is worth doing. The interventions with the biggest body composition effects are very often the worst things you can do for your long-term health. In this video, Dr. Quinn Stillson (MD + strength coach) ranks EVERY body recomposition intervention on three axes: how much muscle and fat it actually moves in kilograms, what it costs you on the longevity axis, and how much human evidence actually exists. Everything gets plotted on one graph — from creatine to trenbolone — so you can see the trade-off for yourself instead of being told what to think. The result: five free, unglamorous interventions get you 80–90% of the best body composition you can reach without paying for it somewhere else. Everything else is competing for what's left. In this video, you'll learn: Why testosterone is the perfect case study for how dose and duration drive BOTH efficacy and longevity harm Tier 1: the exact resistance training volume, cardio prescription, step count, deficit size, protein target, and sleep parameters — with the kg effect size for each How much muscle and fat you can actually gain and lose naturally (the FFMI ceiling) Why GLP-1s are Tier 1b and not Tier 1 — and what most people get wrong about muscle loss on them Comprehensive lab optimization: the full panel and what fixing your deficiencies is actually worth Creatine's real effect size — and why it nearly matches TRT at 1% of the cost GH peptides: the honest efficacy number, who's a candidate, and why the gains are rented, not owned Myostatin/activin inhibitors (bimagrumab) — the best recomp data in existence, and why you can't get it MOTS-c, 5-Amino-1MQ, SLU-PP-332 — what the animal data shows and why it likely won't transfer Anabolic steroids: what they actually give you, what the cardiovascular data really says, and how much you keep after stopping Supraphysiologic GH: 27 RCTs, increased lean mass, zero strength improvement SARMs, insulin, clenbuterol, and DNP — ranked honestly, not dismissed Why HMB, collagen, omega-3, citrulline, and EAAs didn't make any tier Best for: – Anyone who wants to build muscle and lose fat without trading away healthspan – People currently using or considering peptides, TRT, or anabolic steroids – Lifters who've plateaued and are deciding what to add next – Clinicians and biohackers who want effect sizes and evidence grades, not opinions – Anyone tired of being sold supplements that do nothing Timestamps 00:00 Efficacy, Longevity, & Strength of Evidence - The Ranking Axes 01:59 Testosterone (Men & Women) - Doses for Efficacy + Longevity 07:41 Importance of Tier 1 & How We’re Ranking the Interventions 09:18 Optimizing Resistance Training for Muscle Growth 12:24 Optimizing Aerobic Training for Body Recomp 16:41 Tracking NEAT (Non-Exercise Activity Thermogenesis) 18:22 Calorie Deficit - How Large Should Your Deficit Be? 20:09 Protein - Daily Amount & Timing 22:45 Sleep Optimization for Body Recomp - Duration, Timing, Alcohol 26:14 How Much Muscle Can You Actually Gain Naturally with Tier 1? 28:29 How to Track Body Composition at Home 30:16 GLP-1s - Why They’re NOT Tier 1 35:00 Cagrilintide & Amylin Agonists - Add-Ons to GLP-1s? 36:24 Myostatin/Activin Inhibitors (Bimagrumab) - The Future of Body Recomp? 38:12 Tier 2 - Lab Optimization (+ Starting Lab Panel for Body Recomp) 42:56 Creatine - Why It’s Still UNDERrated 45:27 Tier 3 - GH Peptides - ACTUAL Effect Size (Overrated?) 51:33 Tier 4 - MOTS-c - Do You Need it to Optimize GLP-1 Use? 54:24 5-Amino-1MQ & SLU-PP-332 - Worth The Cost? 56:59 Tier 5 - Anabolic-Androgenic Steroid Use (Long-Term) 01:01:21 Short-Term Anabolic Use - Lower Risk? 01:05:08 Efficacy of Short-Term Anabolic Use - Do Gains Last After Stopping? 01:09:34 Growth Hormone (Supraphysiologic) & GH vs GH Peptides 01:13:17 SARMs, Insulin, Clenbuterol, & DNP 01:15:40 Why Most Interventions Aren’t Worth It Get the free peptide guide at my website: quinnstillsonmd.com Purchase the Hume Body Pod below (FSA/HSA eligible) — up to 50% off! Code: QUINN https://humehealth.com//discount/QUINN?redirect=/pages/hume-body-pod&utm_source=youtube&utm_medium=influencer&utm_campaign=QUINN Subscribe for weekly videos on peptides, longevity & performance! Medical Disclaimer This video is for educational purposes only and does not constitute medical advice. Several compounds discussed are not FDA-approved and are available for research purposes only. Long-term safety and efficacy in humans have not been established for many of the interventions covered. Always consult a qualified healthcare provider before starting any medication, peptide, or supplement. #BodyRecomposition #BuildMuscle #FatLoss #Longevity #Peptides #TRT #Creatine #GLP1
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    1 ora e 18 min
  • CJC-1295, Ipamorelin, Tesamorelin & Sermorelin: Deep Dive on the Best GH Peptides

    CJC-1295, Ipamorelin, Tesamorelin & Sermorelin: Deep Dive on the Best GH Peptides
    Apr 5 2026
    Growth hormone peptides like CJC-1295, Ipamorelin, Tesamorelin, and Sermorelin are some of the most popular compounds in longevity and performance medicine—but most people using them are asking the wrong question. They want to know which peptide increases GH the most. But more GH isn't always better, and the way you increase it matters just as much as how high you drive it. In this video, Dr. Quinn Stillson (MD + strength coach) breaks down the full science behind GH peptides: how growth hormone actually works, why CJC-1295 with DAC disrupts normal physiology, what the clinical data on Tesamorelin and Sermorelin actually shows, why Ipamorelin is the only GHRP worth recommending for most people, and how to weigh the real benefits of these peptides against their real risks—including insulin resistance, cancer progression, and potential lifespan tradeoffs. This isn't Reddit dosing lore. This is the evidence-based deep dive. Whether you're exploring GH peptides for body composition, visceral fat loss, recovery, or longevity—this is the most thorough breakdown of CJC-1295, Ipamorelin, Tesamorelin, Sermorelin, and MK-677 you'll find. In this video, you'll learn: How growth hormone actually works—and why increasing it isn't always anti-aging The real benefits of GH and IGF-1 (and the downsides most content ignores) Normal GH physiology and why pulsatility matters CJC-1295 with DAC vs without DAC—and why this distinction changes everything Sermorelin vs Tesamorelin vs CJC-1295 (no DAC): half-lives, potency, and clinical data compared Why CJC-1295 with DAC raises trough GH 7.5-fold and why that's a problem The only human clinical data we actually have—and what's missing GHRP deep dive: GHRP-6, GHRP-2, Hexarelin, Ipamorelin & MK-677 compared Why Ipamorelin is the only selective GHRP and what that means practically Why GHRP monotherapy likely won't raise IGF-1 long-term The synergistic effect of combining a GHRH + GHRP—and the human data behind it How to decide which GHRH analogue is right for you based on your health profile Who should and shouldn't consider GH peptides at all Best for: – Anyone researching CJC-1295, Ipamorelin, Tesamorelin, or Sermorelin – Individuals exploring GH peptides for fat loss, muscle gain, or recovery – Longevity-focused individuals who want the tradeoffs, not just the benefits – Clinicians and practitioners exploring peptide-based therapies – Biohackers wanting an evidence-based breakdown that goes beyond community protocols – Anyone who's heard conflicting things about CJC-1295 with vs without DAC Timestamps 00:00 Are You Using the Wrong GH Peptides? 01:26 Benefits of Increasing GH and IGF-1 04:17 Downsides of Increasing GH and IGF-1 07:45 GH Replacement with Aging vs Using GH Peptides 10:18 Normal Growth Hormone Physiology (GH, Ghrelin, Somatostatin, IGF-1) 14:38 How the Different GH Peptides Act on the GH Pathway 15:49 GHRH Analogue Structures - CJC-1295 vs Sermorelin vs Tesamorelin 17:59 Half-Lives of CJC-1295 Without DAC vs Sermorelin vs Tesamorelin 20:00 Negatives of CJC-1295 With DAC Compared to Without DAC 23:45 Potency of CJC-1295 vs Sermorelin vs Tesamorelin 25:51 Sermorelin Human Studies Review 28:17 Tesamorelin Human Studies Review 32:18 CJC-1295 With and Without DAC Human Studies Review 34:50 Costs of CJC-1295 vs Tesamorelin vs Sermorelin 35:29 When to Use (or Not Use) CJC-1295 With DAC 38:15 When to Use CJC-1295 Without DAC vs Tesamorelin vs Sermorelin 46:20 GHRP’s and Ghrelin - How to Differentiate by Selectivity, Potency, & Half-Life 48:19 GHRP Overview - Ipamorelin vs Ghrelin vs GHRP-6 vs GHRP-2 vs Hexarelin 52:51 MK-677 - Oral Route, Long Half Life, Human Data, and vs Ipamorelin 57:53 Why You Should Not Use a GHRP Alone (Desensitization) 01:00:44 Synergy of a GHRH + GHRP (i.e. CJC-1295 and Ipamorelin Together) 01:02:52 When Should You Add in Ipamorelin to Your GH Peptide Stack? 01:04:22 Should YOU Use GH Peptides At All? 01:05:18 Benefits of GH Peptides 01:08:00 Risks of GH Peptides Related Video Top 5 Peptides for Longevity → https://youtu.be/22mUkD8bNds Subscribe for more: Weekly videos on peptides, longevity & performance Next: GH Peptides Part 2 — Dose, Timing, Frequency & Cycles Medical Disclaimer This video is for educational and informational purposes only and does not constitute medical advice. Other than Tesamorelin, GH peptides are not approved by the FDA for human use and are sold for research purposes only. Their safety and effectiveness have not been established in human clinical trials, and long-term risks are unknown. Do not use this information to diagnose or treat any medical condition. Always consult a qualified healthcare provider before making any medical decisions. #CJC1295 #Ipamorelin #GHPeptides #Peptides #Longevity
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    1 ora e 13 min
  • GHK-Cu (Copper Peptide) Deep Dive: Mechanisms, Benefits, Risks, Forms, & Dosing

    GHK-Cu (Copper Peptide) Deep Dive: Mechanisms, Benefits, Risks, Forms, & Dosing
    Jan 24 2026
    GHK-Cu (Copper Peptide) is one of the most biologically active and versatile peptides ever discovered—playing a critical role in tissue repair, skin regeneration, hair growth, inflammation control, and gene regulation. Naturally present in human plasma, saliva, and urine, GHK-Cu declines with age, and that decline may contribute to slower healing, skin aging, hair loss, and impaired regenerative capacity. But what does the science actually show? And how far do the benefits really extend beyond skincare? In this video, Dr. Quinn Stillson (MD + strength coach) breaks down the full science behind GHK-Cu: how it binds copper, regulates over 4,000 human genes, modulates inflammation, stimulates collagen and extracellular matrix repair, enhances angiogenesis, and supports stem-cell–like regenerative signaling. We explore the human, animal, and mechanistic data on skin aging, hair regrowth, wound healing, musculoskeletal repair, cardiovascular health, gut and lung tissue integrity, neuroprotection, and even cancer-related pathways—while clearly separating evidence from speculation. Whether you're interested in skin rejuvenation, hair restoration, injury recovery, or building a serious longevity stack—this is the definitive deep dive on GHK-Cu. In this video, you’ll learn: What GHK-Cu actually is and why it naturally declines with age How GHK-Cu regulates thousands of genes involved in repair and inflammation Why it’s one of the most powerful peptides for skin regeneration and collagen synthesis The evidence for hair regrowth and follicle stimulation Effects on wound healing, angiogenesis, and connective tissue repair Anti-inflammatory and antioxidant mechanisms Potential benefits for cardiovascular, lung, gut, and nervous system health GHK-Cu and cancer pathways: what’s protective vs theoretical Topical vs injectable GHK-Cu—what the data suggests Dosing ranges, frequency, cycling strategies, and timing Copper toxicity concerns, safety considerations, and lab monitoring Who may benefit most—and who should be cautious Best for: – Anyone focused on skin health, hair regrowth, or anti-aging – Individuals recovering from injuries or chronic inflammation – Longevity-focused individuals optimizing tissue repair and regeneration – Clinicians exploring regenerative and peptide-based therapies – Biohackers wanting an evidence-based breakdown of copper peptides – Those curious about injectable vs topical peptide strategies Timestamps 00:00 GHK-Cu - Most Versatile Peptide? 00:41 Structure and Mechanism of GHK-Cu 02:19 Skin Regeneration & Anti-Aging Effects of GHK-Cu 08:08 Hair Growth Effects of GHK-Cu 09:23 Anti-Inflammatory & Anti-Oxidant Actions of GHK-Cu 12:03 Musculoskeletal, Gut, Lung, & Liver Healing from GHK-Cu 18:27 Anti-Cancer Actions of GHK-Cu 21:21 Cardiovascular Effects of GHK-Cu (Decreasing Fibrinogen) 23:10 Neuroprotection & Neurologic Effects of GHK-Cu 25:41 Longevity & Anti-Aging Effects of GHK-Cu 28:00 Copper Toxicity Risks and Lab Monitoring While on GHK-Cu 31:15 Cancer Risk With GHK-Cu 32:19 Overall Safety Profile and Topical Safety 33:05 Limiting Burning Sensation with Injectable GHK-Cu 33:51 Who Might Benefit from GHK-Cu? Risk-Benefit Discussion 37:27 Are Topical Forms Effective? & How To Optimize Topical Use 42:30 Topical vs Injectable GHK-Cu - When to Use Each 45:23 AHK-Cu vs GHK-Cu - Which is Better for Hair and Longevity? 46:36 Dosing of Injectable and Topical GHK-Cu 51:18 Frequency of GHK-Cu Administration 52:26 Cycle Lengths for GHK-Cu Related Video Top 5 Peptides for Longevity → https://youtu.be/22mUkD8bNds Subscribe for more: Weekly videos on peptides, longevity & performance Next: Deep Dive on Selank and Semax Medical Disclaimer This video is for educational purposes only. Injectable GHK-Cu is not FDA-approved for human use, and long-term safety data is limited. All non-topical uses are based on preclinical or mechanistic data. Always consult a qualified healthcare professional before starting any peptide or medical therapy. #GHKCu #CopperPeptide #Peptides #AntiAging #Longevity
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    54 min
  • MOTS-c (CB-4211): Exercise in a Vial? Full Deep Dive (Benefits, Risks & Dosing)

    MOTS-c (CB-4211): Exercise in a Vial? Full Deep Dive (Benefits, Risks & Dosing)
    Dec 5 2025
    MOTS-c is one of the most intriguing mitochondrial-derived peptides ever discovered—an exercise- and fasting-mimicking molecule produced inside your mitochondria during stress. Early research shows it may improve metabolic health, reduce obesity in animals, enhance endurance, protect against age-related decline, and even influence muscle maintenance, bone health, and cognitive function. But what’s real? What’s hype? And how might CB-4211—the pharmaceutical MOTS-c analogue—fit into the future of longevity medicine? In this video, Dr. Quinn Stillson (MD + strength coach) breaks down the full science behind MOTS-c and CB-4211: how they activate AMPK, modulate the folate/purine cycles, boost metabolic flexibility, improve mitochondrial function, and trigger mitohormesis—the “come back stronger” effect. We cover the human data on CB-4211, the robust animal research on MOTS-c, the anti-aging implications, the metabolic effects, potential risks (including homocysteine elevation), and what hypothetical dosing could look like if these peptides were ever FDA-approved. Whether you're exploring mitochondrial health, metabolic optimization, exercise adaptation, or building a serious longevity stack—this is the deep dive you need on MOTS-c and CB-4211. In this video, you’ll learn: What MOTS-c actually is—and why your mitochondria produce it under stress How MOTS-c activates AMPK → SIRT1 → PGC-1α for mitochondrial biogenesis Why MOTS-c is often called “exercise in a vial” How it impacts metabolic flexibility, insulin sensitivity, and fat oxidation Evidence for reducing insulin resistance & obesity in animal models Human clinical data from the CB-4211 Phase 1 NAFLD trial Why MOTS-c levels decline with age—and why that matters for longevity The peptide’s effects on endurance, muscle maintenance, bone health, and neuroprotection Mechanistic risks: homocysteine elevation, folate depletion, and overstressing mitochondria Hypothetical forms, dosing, timing, and cycling strategies (if FDA-approved) Who might benefit most—from metabolic syndrome to endurance athletes to longevity-focused individuals Best for: – Anyone building a longevity or mitochondrial-support protocol – Individuals with insulin resistance, metabolic syndrome, or fatty liver – People wanting to improve endurance, fatigue resistance, or aerobic fitness – Those focused on healthy aging, mitochondrial decline, or exercise adaptation – Clinicians exploring mitochondrial-derived peptides – Biohackers wanting a clear, evidence-based breakdown of MOTS-c Timestamps 00:00 MOTS-c - Exercise in a Vial? 00:47 Overview of MOTS-c Mechanism 01:47 How MOTS-c Works - AMPK, SIRT1, PGC-1α & Metabolic Flexibility 03:45 Mitohormesis- How MOTS-c Enhances Stress Resilience 05:24 CB-4211 - The MOTS-c Analogue - Structure & Differences 07:04 MOTS-c for Weight Loss & Metabolic Syndrome 08:37 Anti-Aging, Longevity & Healthspan Effects 11:15 Exercise Performance, Muscle Health & Endurance 14:44 Bone Health and Neuroprotection (Alzheimer's and Parkinson’s) 15:55 Heart Health & Other Experimental Use Cases 17:21 Safety Concerns: Homocysteine & Folate 19:52 Overstressing the Mitochondria & Supplements to Avoid This 23:00 Who Might Benefit from MOTS-c? (If FDA Approved) 26:04 MOTS-c vs CB-4211 26:45 Oral vs Injectable (Subq) MOTS-c 27:51 Optimal Dose and Frequency of MOTS-c 31:30 Timing of MOTS-c Injections - Pre-Exercise? Time of Day? 32:18 Cycles for MOTS-c and Sourcing Related Videos SS-31 Deep Dive → https://youtu.be/cjUm5gkSwRk TB-4 & TB-500 → https://www.youtube.com/watch?v=vvBAsQBji0A Subscribe for more: Weekly videos on peptides, metabolism & longevity. Next: Top 5 Peptides for Longevity Medical Disclaimer This video is for educational purposes only. MOTS-c and CB-4211 are not FDA-approved for human use, and their safety has not been established. All non-CB-4211 uses are theoretical and based on preclinical data. Always consult a qualified healthcare provider before starting any peptide or medication. #MOTSc #CB4211 #MitochondrialPeptides #LongevityPeptides #AntiAging #AMPK #Mitochondria #FunctionalMedicine #MetabolicHealth #ExerciseScience #HealthyAging
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    34 min