Statins (HMG-CoA Reductase Inhibitors) are the foundation of LDL lowering and ASCVD prevention. In this lecture from This is Why, Dr. Busti will make statin pharmacology easy to understand, but also clinically relevant in the proper context of the evidence. The use of HMG CoA reductase inhibitors: atorvastatin, rosuvastatin, simvastatin, pitavastatin, and pravastatin are drugs in this drug class that Dr. Busti will review.

You’ll learn how to:

• MOA: How HMG-CoA reductase inhibitors reduce hepatic cholesterol synthesis and increase LDL clearance
• Clinical uses: Hyperlipidemia treatment, primary prevention, and secondary prevention for ASCVD
• High-yield statins: Atorvastatin, rosuvastatin, simvastatin, pravastatin (and how to think about intensity)
• Adverse effects: Statin myopathy, muscle pain/weakness, and rare rhabdomyolysis
• Key interactions: CYP3A4 interactions (especially with certain statins) and what to watch for clinically
• Pearls for exams: How to connect lipid lowering drugs to patient cases and test questions

The goal = make medical education easy and clinically relevant.

Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/statins-hmg-coa-reductase-inhibitors-ldl-lowering

Get more with a free membership at https://www.thisiswhy.health/

• Access free downloads from our videos
• Access deep dive content from Dr. Busti
• Organize content via playlists & collections
• Join live Q&A
• Receive member newsletters
• Coupons & discounts for exam prep resources

If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content.

Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more!

#statins #hmgcoareductaseinhibitors #ldllowering #lipidloweringdrugs #busti

Disclaimer:

This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

Omega-3 fatty acids made easy: learn EPA vs DHA, how fish oil works, and when to use icosapent ethyl (Vascepa) in real clinical practice. In this lecture from This is Why, Dr. Busti connects PUFAs (polyunsaturated fatty acids) to outcomes, focusing on triglyceride lowering, cardiovascular risk reduction, and the key differences between OTC fish oil supplements and prescription EPA.

You’ll learn how to:

• What omega-3 fatty acids (EPA & DHA) are and how they work
• Fish oil (EPA vs DHA): what matters clinically (and what doesn’t)
• How omega-3s affect triglycerides and hypertriglyceridemia
• Icosapent ethyl vs “fish oil”: dosing, indications, and counseling

The goal = make medical education easy and clinically relevant.

Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/omega-3-fatty-acids-epa-vs-dha-fish-oil-icosapent-ethyl

Get more with a free membership at https://www.thisiswhy.health/

• Access free downloads from our videos
• Access deep dive content from Dr. Busti
• Organize content via playlists & collections
• Join live Q&A
• Receive member newsletters
• Coupons & discounts for exam prep resources

If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content.

Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more!

#omega3fattyacids #fishoil #icosapentethyl #EPADHA #busti

Disclaimer: This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.

Learn fibrates (fibric acid derivatives)—fenofibrate and gemfibrozil—common triglyceride-lowering drugs for hypertriglyceridemia. In this lecture from This is Why, Dr. Busti will break down how fibrates (fenofibrate and gemfibrozil) work, when to use them, and the safety pearls you need for the patient with high triglycerides, which can lead to pancreatitis.

You’ll learn how to:
- Mechanism: PPAR-α activation → ↓ triglycerides (TG), ↓ VLDL, ↑ HDL
- Fenofibrate vs gemfibrozil: key differences that matter for practice questions
- Indications: managing high triglycerides (including reducing pancreatitis risk in severe TG)
- Adverse effects & monitoring: myopathy risk, LFTs, gallstones, and what to watch for
- Drug interactions: especially with statins (testable!)

The goal = make medical education easy and clinically relevant.

👉 Access bonus materials and downloads from this episode at: https://www.thisiswhy.health/topics/fibrates-fenofibrate-gemfibrozil-hypertriglyceridemia-triglycerides-pharmacology

👉 Get more with a free membership at https://www.thisiswhy.health/
- Access free downloads from our videos
- Access deep dive content from Dr. Busti
- Organize content via playlists & collections
- Join live Q&A
- Receive member newsletters
- Coupons & discounts for exam prep resources

👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content.

🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures in pharmacology, medical rounds, and more!

#fibrates #fenofibrate #gemfibrozil #hypertriglyceridemia #busti

Disclaimer:
This content is for educational purposes only and is not medical advice. It does not replace individualized evaluation, diagnosis, or treatment. Always seek the advice of a qualified health provider with questions about a medical condition and never delay care because of educational content.