The Science of Letting Go explores how meditation works in the brain, drawing on neuroscience, predictive processing, and contemplative science to explain how letting go reduces stress, softens self-related thinking, and changes perception over time.

In this episode of The FitMind Podcast, we sit down with PhD researcher Shawn Prest from Monash University about what's actually happening under the hood when we meditate. Rather than framing letting go as a vague emotional release, Shawn describes it as a measurable shift in how the brain assigns confidence to its highest-level models, including the sense of self.

They explore how the brain functions as a prediction system, why excessive certainty can create mental tension and suffering, and how meditation helps loosen rigid patterns by shifting perception toward more direct sensory experience. These changes can support greater equanimity, reduced reactivity, and long-term improvements in well-being.

Topics include:

• How meditation changes self-related brain activity

• What "letting go" means from a neuroscience perspective

• The difference between insight-based and absorption-based meditation paths

• Why equanimity feels relieving rather than dull or passive

A grounded, science-forward conversation for anyone curious about how meditation really works and why letting go can reduce suffering.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

Show Notes

0:00 | Intro and why study the mechanics of meditation

4:40 | From meditator to researcher

9:10 | The brain as a prediction machine

14:20 | Valence, well-being, and suffering

18:50 | Why computational models matter

24:30 | Hierarchies in the brain

31:10 | What letting go actually is

37:40 | Why letting go feels relieving

43:50 | Mental tension vs physical tension

49:30 | Modeling letting go computationally

55:50 | Applying letting go on a stressful day

1:02:30 | Trauma, caution, and meditation

1:09:20 | Jhana and insight paths

1:18:40 | Cessation and lasting change

1:27:30 | Equanimity as perception

1:34:40 | The future science of awakening

Clinical psychologist and contemplative science researcher Dr. Nicholas Van Dam joins us to explore the ethics of meditation and what scientific research reveals about how contemplative practices actually work. He examines how much practice is needed to see meaningful change, why challenging experiences can arise, and what current methods can and cannot reliably measure.

We discuss the importance of informed consent in meditation, the role of wisdom traditions alongside modern science, and why honesty and nuance are essential as these practices enter mental health, education, and digital platforms. Dr. Van Dam also shares how contemplative science can support deeper understanding, responsibility, and care as meditation becomes more widely adopted.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

SHOW NOTES

0:00 | Science, wisdom traditions, and the modern search for meaning

1:46 | Introducing Nicholas Van Dam and the ethics of contemplative science

3:00 | Early life, religious roots, and the path into meditation research

5:35 | From brain science to real-world mental health impact

7:30 | Building an agnostic contemplative research centre in Australia

13:10 | Ethics, bias, and responsibility in meditation research

17:00 | Translating between science and wisdom traditions

20:45 | How much meditation is enough? What dose-response research shows

26:45 | Challenging meditation experiences and informed consent

33:00 | The "missing middle": maps, stages, and what comes after beginner programs

40:50 | Equanimity, emotion, and tensions with modern life and values

52:45 | Engagement vs efficacy: why some practices are easier to sustain

1:03:00 | Retreats, daily practice, sleep, and intensity trade-offs

1:13:00 | Neuroplasticity and the limits of brain-based explanations

1:17:15 | Neurofeedback, psychedelics, and the ethics of shortcuts

1:24:15 | Mapping inner experience and the future of contemplative science

1:32:15 | AI, teachers, and scaling wisdom without losing depth

1:38:20 | The future of contemplative science and FitMind's role

1:45:21 | Where to learn more

Contemplative Studies Centre Website: https://psychologicalsciences.unimelb.edu.au/CSC

Nicholas Van Dam's Personal Website: https://www.nicholastvandam.com

Social neuroscientist Dr. Tania Singer joins us to explore the science of empathy, compassion, and the plasticity of the social brain. She breaks down why empathy and compassion are entirely different neural states, what her research with Buddhist monks revealed, and why compassion, not empathy, is the more resilient response to suffering.

We discuss the ReSource Project's surprising findings, including why interpersonal "dyadic" practices reduce social stress far better than solo meditation. Dr. Singer also shares how these practices are being brought into schools, healthcare, and even economic thinking to help create a more caring society.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

SHOW NOTES

00:00 | Empathy vs. Compassion: Understanding the Brain Networks

02:57 | The Journey into Social Neuroscience

06:15 | Landmark Studies on Empathy and Pain

10:50 | Compassion: A Deeper Understanding

14:32 | The Resource Project: Mental Training Programs

20:47 | Dyadic Practices: Enhancing Social Connection

24:34 | Cortisol Levels and Social Stress

28:40 | Implementing Programs in Education and Healthcare

34:14 | Caring Economics: A New Vision for Society

40:49 | Where to Find Dr. Singer's Courses

Dr. Singer's Website: https://taniasinger.de

Cognitive scientist Dr. Therese Huston joins The FitMind Podcast to share practical, research-backed ways to sharpen focus, lower stress, and keep the brain healthy at any age. Drawing from decades of neuroscience, she explains why multitasking quietly erodes attention and memory and what to do instead.

We explore simple, realistic habits that help your mind function at its best: 20-minute single-task blocks, 40 Hz binaural beats for deep focus, and a brief 5-2-7 breathing technique that can quickly calm the nervous system. Dr. Huston also highlights how aerobic movement, dance, and social connection drive neurogenesis and long-term brain vitality.

If you've ever felt scattered, stressed, or mentally drained, this episode offers grounded science and clear tools for regaining clarity and calm in daily life.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

SHOW NOTES

00:00 | Intro to Dr. Therese Huston

07:45 | Wellness overwhelm and how she filters research into usable habits

10:06 | Why "practical" matters more than trendy protocols

12:20 | The multitasking myth: short-term mood boost, long-term costs

17:09 | Live demo: single-tasking vs alternating tasks

19:40 | Errors, brain activity, and stress during multitasking

21:51 | Escaping the multitasking loop with timers and clear agreements

24:30 | Focus tools: how to use 40 Hz binaural beats

28:47 | Why multitasking feels productive and how to reframe arousal

32:33 | Before a talk: "excited, not anxious" and stress-as-fuel

36:03 | Guided 5-2-7 breathing and what it does in the body

41:18 | CO₂, vagus nerve, and decision quality after breath cycles

43:19 | Rethinking "amygdala hijack" and protecting prefrontal control

48:18 | BDNF, neurogenesis, and an aerobic exercise target for memory

51:24 | Dance, social connection, and brain longevity

52:53 | Quick fire: myths to ditch and personal focus resets

54:45 | Exercise snacks and team culture ideas

World champion freediver Will Trubridge explores the depths of the mind and ocean, sharing mental techniques honed through decades of extreme performance.

In this episode, he explains how breathwork, mindfulness, and what he calls the "mental immune system" can help us face fear, build resilience, and expand awareness.

Discover how lessons from the deep sea translate into a healthier, more conscious life on land.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

SHOW NOTES

00:00 | Intro to Will Trubridge

01:21 | Will's Background & Early Freediving

04:59 | Role of Breathwork

09:43 | Physiological Adaptations Underwater

14:16 | Overcoming Fear and Mental Barriers

19:41 | Consciousness in Freediving

26:23 | Parallels to Meditation

31:59 | Limits of the Mind

39:56 | The Mental Immune System

43:59 | Practical Mental Techniques

50:26 | Applying Freediving Lessons to Life

54:53 | Science of Freediving

1:01:31 | Mind-Body Connection

1:09:41 | Awareness Training & Breathwork Exercises

1:14:59 | Closing Insights

Website: https://www.williamtrubridge.com

Mental Immune System: https://mentalimmunesystem.com

Can cells outside the brain learn, remember, and make decisions?

In this episode, neuroscientist Dr. Nikolay Kukushkin shares groundbreaking research that shows even non-neuronal cells can recognize patterns, count, and store information in ways strikingly similar to brain cells.

We explore:

• Why memory may not be limited to the brain

• What sea slugs can teach us about human cognition

• How prediction and perception shape our sense of self

• The parallels between AI and biological intelligence

• Whether trauma could be "stored" in cells outside the nervous system

Dr. Kukushkin's work suggests we rethink intelligence, not as something exclusive to the brain, but as a fundamental property of life.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

SHOW NOTES

0:00 | Intro to Nikolay Kukushkin, PhD

5:10 | Memory in Seaslugs

10:25 | Cells Can Recognize Patterns

20:28 | Memory Defined

23:02 | Do Cells Store Trauma?

30:40 | Treatment for Neurological Conditions

38:40 | Brain & Memory Connection

42:25 | Optimal Interval for Superior Memory

44:52 | Layering of Predictions

50:35 | AI Inspired by Neuronal Behavior

52:27 | Cellular Cognition & Memory

54:47 | Intelligence of Non-Brain Cells

58:38 | Consciousness in Microtubules

1:06:15 | Where to Follow His Work

Website: https://www.nikolaykukushkin.com

One Hand Clapping Book: https://www.nikolaykukushkin.com/press-1

Follow on X: https://x.com/niko_kukushkin

Dr. Iain McGilchrist, a psychiatrist, philosopher, and author, joins the FitMind Podcast to explain how the brain's two hemispheres shape our perception, attention, and consciousness. He explores how the left brain's dominance in modern culture leads to a fragmented, analytical worldview, while the right hemisphere offers a more connected, meaningful experience of reality.

We discuss the moral and spiritual dimensions of attention, the limits of language, the nature of consciousness and the self, and how walking supports fluid thinking. McGilchrist also shares insights from his recent work with biologist Mike Levin on emergence and form.

This episode combines neuroscience, philosophy, and spirituality, inviting a shift toward a more balanced and integrated perspective on the world.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

SHOW NOTES

0:00 | Intro to Iain McGilchrist

2:09 | Attention in Left & Right Brain

17:00 | How the Left Brain Came to Dominate

19:08 | Brain Hemispheres & Happiness

25:25 | Why Right Brain is the True Master

34:30 | Great Truths

35:19 | Morality of Attention

41:44 | Explaining Sacred

45:12 | Shortcomings of Language

51:28 | Distinct vs. Divided

56:20 | Balancing Brain Hemispheres

1:06:31 | Sense of Self & Relations

1:12:15 | Mirror Neurons

1:14:32 | Walking for Fluidity of Thought

1:23:34 | Consciousness Theory

1:31:07 | Water Analogy

1:35:52 | Work with Mike Levin

1:46:22 | Where to Follow His Work

Substack: https://iainmcgilchrist.substack.com/

Website: https://channelmcgilchrist.com

Psychologist and leading self-compassion researcher Dr. Kristin Neff shares how treating yourself with kindness, especially in moments of failure, can boost motivation, resilience, and mental health.

We explore the science behind self-compassion, its impact on performance and emotional regulation, and how to shift from self-criticism to a more constructive inner voice.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

Show Notes

0:00 | Intro to Dr. Kristin Neff

3:52 | Compassion vs. Empathy

8:12 | 3 Core Components of Self-Compassion

13:52 | Role of Personal Responsibility

16:52 | Healthier Alternative to Self-Esteem

20:07 | Common Misconceptions

23:16 | Learning, Flow & Performance

28:32 | How Self-Compassion Impacts Others

31:40 | Physical Touch

33:42 | Depression, Anxiety & Grief

41:14 | Steps to Cultivate Self-Compassion

46:00 | Self-Compassion Break (Exercise)

55:13 | Forgiveness

1:01:06 | Taking Action

1:02:48 | Explore more resources from Dr. Neff at 🔗 self-compassion.org