The Science of Letting Go explores how meditation works in the brain, drawing on neuroscience, predictive processing, and contemplative science to explain how letting go reduces stress, softens self-related thinking, and changes perception over time.

In this episode of The FitMind Podcast, we sit down with PhD researcher Shawn Prest from Monash University about what's actually happening under the hood when we meditate. Rather than framing letting go as a vague emotional release, Shawn describes it as a measurable shift in how the brain assigns confidence to its highest-level models, including the sense of self.

They explore how the brain functions as a prediction system, why excessive certainty can create mental tension and suffering, and how meditation helps loosen rigid patterns by shifting perception toward more direct sensory experience. These changes can support greater equanimity, reduced reactivity, and long-term improvements in well-being.

Topics include:

• How meditation changes self-related brain activity

• What "letting go" means from a neuroscience perspective

• The difference between insight-based and absorption-based meditation paths

• Why equanimity feels relieving rather than dull or passive

A grounded, science-forward conversation for anyone curious about how meditation really works and why letting go can reduce suffering.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

Show Notes

0:00 | Intro and why study the mechanics of meditation

4:40 | From meditator to researcher

9:10 | The brain as a prediction machine

14:20 | Valence, well-being, and suffering

18:50 | Why computational models matter

24:30 | Hierarchies in the brain

31:10 | What letting go actually is

37:40 | Why letting go feels relieving

43:50 | Mental tension vs physical tension

49:30 | Modeling letting go computationally

55:50 | Applying letting go on a stressful day

1:02:30 | Trauma, caution, and meditation

1:09:20 | Jhana and insight paths

1:18:40 | Cessation and lasting change

1:27:30 | Equanimity as perception

1:34:40 | The future science of awakening

Clinical psychologist and contemplative science researcher Dr. Nicholas Van Dam joins us to explore the ethics of meditation and what scientific research reveals about how contemplative practices actually work. He examines how much practice is needed to see meaningful change, why challenging experiences can arise, and what current methods can and cannot reliably measure.

We discuss the importance of informed consent in meditation, the role of wisdom traditions alongside modern science, and why honesty and nuance are essential as these practices enter mental health, education, and digital platforms. Dr. Van Dam also shares how contemplative science can support deeper understanding, responsibility, and care as meditation becomes more widely adopted.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

SHOW NOTES

0:00 | Science, wisdom traditions, and the modern search for meaning

1:46 | Introducing Nicholas Van Dam and the ethics of contemplative science

3:00 | Early life, religious roots, and the path into meditation research

5:35 | From brain science to real-world mental health impact

7:30 | Building an agnostic contemplative research centre in Australia

13:10 | Ethics, bias, and responsibility in meditation research

17:00 | Translating between science and wisdom traditions

20:45 | How much meditation is enough? What dose-response research shows

26:45 | Challenging meditation experiences and informed consent

33:00 | The "missing middle": maps, stages, and what comes after beginner programs

40:50 | Equanimity, emotion, and tensions with modern life and values

52:45 | Engagement vs efficacy: why some practices are easier to sustain

1:03:00 | Retreats, daily practice, sleep, and intensity trade-offs

1:13:00 | Neuroplasticity and the limits of brain-based explanations

1:17:15 | Neurofeedback, psychedelics, and the ethics of shortcuts

1:24:15 | Mapping inner experience and the future of contemplative science

1:32:15 | AI, teachers, and scaling wisdom without losing depth

1:38:20 | The future of contemplative science and FitMind's role

1:45:21 | Where to learn more

Contemplative Studies Centre Website: https://psychologicalsciences.unimelb.edu.au/CSC

Nicholas Van Dam's Personal Website: https://www.nicholastvandam.com

Social neuroscientist Dr. Tania Singer joins us to explore the science of empathy, compassion, and the plasticity of the social brain. She breaks down why empathy and compassion are entirely different neural states, what her research with Buddhist monks revealed, and why compassion, not empathy, is the more resilient response to suffering.

We discuss the ReSource Project's surprising findings, including why interpersonal "dyadic" practices reduce social stress far better than solo meditation. Dr. Singer also shares how these practices are being brought into schools, healthcare, and even economic thinking to help create a more caring society.

FitMind Neuroscience-Based App: http://bit.ly/afitmind

Website: www.fitmind.org

SHOW NOTES

00:00 | Empathy vs. Compassion: Understanding the Brain Networks

02:57 | The Journey into Social Neuroscience

06:15 | Landmark Studies on Empathy and Pain

10:50 | Compassion: A Deeper Understanding

14:32 | The Resource Project: Mental Training Programs

20:47 | Dyadic Practices: Enhancing Social Connection

24:34 | Cortisol Levels and Social Stress

28:40 | Implementing Programs in Education and Healthcare

34:14 | Caring Economics: A New Vision for Society

40:49 | Where to Find Dr. Singer's Courses

Dr. Singer's Website: https://taniasinger.de