This week on LifeLONG, Ethan Suplee and Dr. Spencer Nadolsky investigate a strange phenomenon that hit fitness centers this January: the gyms were completely empty. We explore the conspiracy theory that the rise of GLP-1 agonists like Ozempic and Wegovy has finally killed the desperate New Year’s Resolution rush, allowing people to focus on their health year-round instead. Dr. Nadolsky breaks down the hard data behind these nuclear tools for weight loss, specifically addressing the terrifying headlines about muscle wasting. He reveals the real difference between Semaglutide, which can result in nearly 40% fat-free mass loss, and Tirzepatide (Mounjaro), which averages closer to 25%, while explaining why DEXA scans often mistake fluid loss for muscle loss.

Beyond the medication, they dive deep into the psychology and physical reality of extreme weight loss. Ethan and Dr. Nadolsky debate the controversial question of whether obesity is truly a choice or a result of genetics clashing with our modern food environment, with Ethan sharing his perspective on how he didn't choose obesity but had to actively choose his recovery. Ethan also gets incredibly vulnerable about the disaster of his loose skin removal surgeries, sharing graphic details about the recovery process that most influencers won't tell you, including the mental toll of being bedridden for weeks. Finally, we discuss why 2026 might be the Year of Fiber, why Dr. Nadolsky ranks it above protein for GLP-1 users, and the specific strategies you need to build muscle while on these medications.

Want to be on a future episode? Register here to join the conversation: 2way.tv/ethansuplee

Don't forget to subscribe to the YouTube for clips, full episodes, and more!

If you have any inspirational quotes to share, post them to Ethan's subreddit, r/EthanSupleeLifeLONG. It’s also a great place to discuss episodes, post about your successes, and embrace the community.

Lastly, you can send video questions to ethansupleeshow@2way.tv and we will play them on the show.

Hosted on Acast. See acast.com/privacy for more information.

Does "staying positive" actually make you feel worse? As we head into the New Year, the pressure to be optimistic and set massive goals can be overwhelming. In this episode of LifeLONG, Ethan sits down with educator and viral content creator Dr. Zac Bauermaster to dismantle the myth of "good vibes only" and explore a more sustainable approach to personal growth.

They kick things off by tackling the concept of "Toxic Positivity," the idea that forcing happiness can actually alienate us from our true feelings and the people around us. Ethan shares why overly chipper advice sometimes makes his skin crawl, while Zach explains how true empathy means sitting with someone in their struggle rather than trying to fix it with a fake smile. If you’ve ever felt guilty for not being happy 24/7, this honest conversation about meeting people where they are is the reality check you need.

Instead of setting rigid New Year's resolutions that are destined to fail by February, Zac introduces the One Word method. Whether it’s "Discipline," "Serve," or "Declutter," choosing a single guiding theme for your year can be more powerful than a checklist of impossible tasks. They discuss how this simple mindset shift helps build consistency without the shame spiral that comes from missed targets.

Ethan and Zac also dive into practical strategies for overcoming analysis paralysis. Drawing on wisdom from a Rich Roll clip, they talk about the danger of overthinking lifestyle changes. Zac shares a brilliant analogy involving his son’s drone: sometimes the goal isn't to fly high immediately, but just to get it off the ground and hover. Whether you are trying to write a book, start a weight loss journey, or just get off the couch, Zac talks about how setting simple timers can snap you out of hesitation and into action.

Finally, they get into the nitty-gritty of health debates, including a candid chat about nicotine lozenges, the confusing science around salt and sodium intake, and the macronutrients of happiness (Enjoyment, Satisfaction, and Purpose). If you are looking for a way to start 2026 with clarity, purpose, and a little less fake positivity, this episode is for you.

Want to be on a future episode? Register here to join the conversation: 2way.tv/ethansuplee

Don't forget to subscribe to the YouTube for clips, full episodes, and more!

If you have any inspirational quotes to share, post them to Ethan's subreddit, r/EthanSupleeLifeLONG. It’s also a great place to discuss episodes, post about your successes, and embrace the community.

Lastly, you can send video questions to ethansupleeshow@2way.tv and we will play them on the show.

Hosted on Acast. See acast.com/privacy for more information.

Can a simple act of kindness actually add years to your life? In this episode of LifeLONG, Ethan Suplee sits down with Lisa DePasquale, author of The Gen X Handbook for Middle Age, to reveal why middle age is actually the most powerful window for a radical life transformation. While many believe their best years are behind them, Ethan and Lisa discuss how the mental fortitude and maturity gained over four decades provide the exact tools needed to make weight loss and health habits finally stick. Lisa shares the details of her incredible journey losing 170 pounds, moving from the tombstone mindset of her 40s to a life defined by strength and success. By shifting from impossible goals to sustainable systems, she proves that aging is not a hurdle, but a strategic advantage for anyone seeking long-term longevity.

The conversation dives deep into the science of kindness, exploring the biological phenomenon known as the "helper’s high." Scientific research shows that performing small, prosocial acts triggers a dopamine hit that significantly boosts the giver’s wellbeing and reduces the stress that often leads to health spirals. Whether it is reframing hard work as a "kindness" to your future self or engaging in micro-interactions at the grocery store to combat seasonal depression, this episode explains why your social connections are just as vital to your health as your macros. We also tackle practical strategies for navigating high-stress periods like the holidays, moving from a mindset of punishment and binging toward one of moderation and recovery.

If you have been searching for 2025 weight loss tips or a wellness mindset that survives the middle age spread, this episode provides the roadmap. From the Great Boomer Wealth Transfer to the unique resilience of Gen Xers, Ethan and Lisa break down how to stop the punishment cycle and start building a life you actually enjoy. Learn how to use your past victories to spiral up and discover why health is truly a lifelong journey that is built, not born.

Join the conversation as we explore how maturity, accountability, and kindness create the ultimate foundation for healthy aging and human fulfillment.

Lisa's book is available here!

Want to be on a future episode? Register here to join the conversation: 2way.tv/ethansuplee

Don't forget to subscribe to the YouTube for clips, full episodes, and more!

If you have any inspirational quotes to share, post them to Ethan's subreddit, r/EthanSupleeLifeLONG. It’s also a great place to discuss episodes, post about your successes, and embrace the community.

Lastly, you can send video questions to ethansupleeshow@2way.tv and we will play them on the show.

Hosted on Acast. See acast.com/privacy for more information.