This week on LifeLONG, Ethan Suplee and Dr. Spencer Nadolsky investigate a strange phenomenon that hit fitness centers this January: the gyms were completely empty. We explore the conspiracy theory that the rise of GLP-1 agonists like Ozempic and Wegovy has finally killed the desperate New Year’s Resolution rush, allowing people to focus on their health year-round instead. Dr. Nadolsky breaks down the hard data behind these nuclear tools for weight loss, specifically addressing the terrifying headlines about muscle wasting. He reveals the real difference between Semaglutide, which can result in nearly 40% fat-free mass loss, and Tirzepatide (Mounjaro), which averages closer to 25%, while explaining why DEXA scans often mistake fluid loss for muscle loss.

Beyond the medication, they dive deep into the psychology and physical reality of extreme weight loss. Ethan and Dr. Nadolsky debate the controversial question of whether obesity is truly a choice or a result of genetics clashing with our modern food environment, with Ethan sharing his perspective on how he didn't choose obesity but had to actively choose his recovery. Ethan also gets incredibly vulnerable about the disaster of his loose skin removal surgeries, sharing graphic details about the recovery process that most influencers won't tell you, including the mental toll of being bedridden for weeks. Finally, we discuss why 2026 might be the Year of Fiber, why Dr. Nadolsky ranks it above protein for GLP-1 users, and the specific strategies you need to build muscle while on these medications.

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