Today, I'm joined by the remarkable Dr. Gabrielle Lyon, a pioneer in redefining the longevity conversation by making muscle health—not weight—the centerpiece of aging well. With a background in geriatrics and nutritional sciences, she illuminates why the quality of your muscle tissue is a far more powerful predictor of health than any number on the scale. Her perspective challenges the notion of a "healthy sedentary person" and reveals the major role of intramuscular fat in metabolic dysfunction.

Episode Timestamps:

Introduction, podcast focus, and welcoming Dr. Gabrielle Lyon ... 00:00:00

Muscle's impact on brain health, inflammation, and healthy aging ... 00:01:03

Dr. Lyon's childhood, grit, and self-discipline ... 00:04:33

Mentorship and protein science under Dr. Donald Lehman ... 00:07:05

Muscle as the overlooked metabolic organ ... 00:08:45

Why intramuscular fat matters more than body weight ... 00:10:06

Plant vs. animal protein for muscle health ... 00:13:29

Muscle as an endocrine organ and cognition ... 00:16:21

Future of muscle science: anabolics, imaging, and technology ... 00:18:22

GLP-1s, sarcopenic obesity, and muscle-first protocol ... 00:46:45

Sarcopenia, aging, and the importance of early training ... 01:04:35

Building lifelong resilience—mental and physical ... 01:08:31

Predictions: anabolics, muscle testing, and assessment ... 01:12:17

"Strength is a responsibility, not a luxury" ... 01:13:53

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Today, I'm joined by the incredible Anthony Castore, a trailblazer who fuses elite strength coaching with deep cellular medicine. In our conversation, Anthony shares his journey from a young athlete determined to defy genetic odds to becoming an expert in both physical training and the nuanced science of peptides, mitochondria, and bioregulators.

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Episode Timestamps:

Welcome and episode introduction ... 00:00:00

Anthony Castore's path from strength coaching to cellular medicine ... 00:05:55

Connecting strength training with cellular pathways (AMPK, mTOR) ... 00:12:27

Explaining and balancing AMPK and mTOR for performance ... 00:13:03

Training strategies: Metabolic, hypertrophy, and neural approaches ... 00:18:18

Building a solid foundation: Lifestyle, training, nutrition, peptides ... 00:23:04

Assessing recovery capacity and individualizing protocols ... 00:26:02

Mitochondrial fission, fusion, and targeted adaptation ... 00:29:57

Optimizing muscle gain and fat loss through calories and recovery ... 00:31:00

Differentiating bodybuilder vs. longevity approaches ... 00:34:44

Integrating peptides and support molecules into routines ... 00:40:44

Ketone esters and mitochondrial peptide interventions ... 00:41:20

Cautions on stacking and combining interventions ... 00:54:04

Lessons learned from overdoing interventions ... 01:05:02

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Today, I'm joined by the deeply thoughtful and refreshingly honest Dr. Sanjay Bhojraj, a self-described "curious cardiologist" who spent decades treating heart attacks in the cath lab — before stepping away to ask a bigger question: Why are we waiting for the crisis instead of preventing it?

Episode Timestamps:

Welcome to Longevity & episode setup … 00:00:00

Dr. Bhojraj's shift from ER cardiology to prevention … 00:06:30

Why most heart attacks aren't caused by big blockages … 00:09:15

Stress, nervous system load & heart attack risk … 00:13:10

CIMT explained: what it measures (and what it misses) … 00:26:40

Calcium scores vs CT angiograms … 00:35:45

CLEERLY scan: seeing dangerous soft plaque … 00:38:45

Can plaque actually regress? … 00:41:55

When heart scans make patients less afraid … 00:44:05

When should you test — even without symptoms? … 00:45:50

Why age 45 is a major cardiovascular inflection point … 00:47:10

Hormones, estrogen loss & women's heart risk … 00:50:10

Why cardiology still misunderstands women … 00:54:30

Small dense LDL, ApoB & oxidized cholesterol … 01:02:00

Why fixing inflammation matters more than numbers … 01:05:50

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