In this week's View, Dr. Eagle looks at a brief report on how cardiac death remains a substantial contributor to on-duty mortality of U.S. firefighters, and how drivers of this trend may not be well identified by the current screening approaches. He then examines a recent article in JACC Heart Failure on how heart failure with improved ejection fraction (HFimpEF) was associated with better outcomes than persistent heart failure with reduced ejection fraction (HFrEF) in both women and men. He follows that with a look at a metanalysis that compared dual antiplatelet therapy (DAPT) and direct oral anticoagulant (DOAC) monotherapy and their effects on device-related thrombosis (DRT) and major bleeding after left atrial appendage occlusion (LAAO). Finally, Dr. Eagle offers a summary of an analysis a recent study the reported modest increase in noninfarct-related artery (non-IRA) revascularization in patients with STEMI and multivessel coronary artery disease (CAD), with some caveats.

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In this week's View, Dr. Eagle looks at the relationship between lower cardiorespiratory fitness (CRF) and higher coronary artery calcium scores (CAC) and later-life dementia. He follows this with a look at a new State of the Art Review related to guidance on treating athletes with arrhythmia. He then offers a perspective on the use of vutrisiran in the treatment of amyloid burden. Finally, Dr. Eagle explores the TARTAN-HF study on NT-proBNP screening and its ability to identify undiagnosed heart failure (HF) among patients with diabetes.

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In this week's View, Dr. Eagle evaluates how sacubitril/valsartan promotes cardiac remodeling, but not functional capacity, in nonobstructive hypertrophic cardiomyopathy. Next, he examines the prognostic value of stress perfusion cardiac magnetic resonance in patients with suspected coronary artery disease. Finally, Dr. Eagle explores a study on mitral transcatheter edge-to-edge repair (M-TEER) and its effectiveness for treatment of patients with ventricular functional mitral regurgitation (MR) and very severe left ventricular (LV) dysfunction.

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