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In Cambridge, 1355, the colleges of the fledgling university are as much at odds with each other as they are with the ordinary townfolk. This tension has recently been heightened by the return of two well-born murderers after receiving the King's pardon, showing no remorse but ready to confront those who helped convict them. And in the midst of this Bartholomew the physician is called to the local mill to examine two corpses. It is almost a relief to be able to turn his back on the fractious town, but as always in Cambridge nothing is disconnected.

Matthew Bartholomew, doctor of medicine and fellow of Michaelhouse, Cambridge, is travelling with a party from the college to accept the gift of the living of a parish in Suffolk. One of his companions, Unwin, an unworldly scholar, is to be installed as priest. Their journey is not without incident - they are chased by footpads, pass through an eerie village abandoned after the recent plague and find a man barely alive on a gibbet - so they reach their destination with some relief. But their thoughts of recovering while enjoying the local Pentecostal Fair are soon curtailed.

In 1350 the people of Cambridge are struggling to overcome the effects of the Black Death - and with a high mortality rate among priests and monks, the townsfolk are vulnerable to sinister cults that have sprung up. At Michaelhouse, Matthew Bartholomew is training new physicians when the body of a friar is found in the massive chest that the university uses to store precious documents. While investigating, Bartholomew stumbles across a derelict church being used as a meeting place for the mysterious sect he believes is at the heart of a web of blackmail.

Superspy of Restoration London, Thomas Chaloner foils an uprising in his eighth outing. Five years after Charles II's triumphant return to London, there is growing mistrust of his extravagant court and of corruption among his officials - and when a cart laden with gunpowder explodes outside the General Letter Office, it is immediately clear that such an act is more than an expression of outrage at the inefficiency of the postal service. 

Thomas Chaloner is relieved to be summoned back to London. His master, the Earl of Clarendon, has sent him to Tangier to investigate a case of corruption. Chaloner will be glad to be home, to be reunited with his new wife, but the trivial reason for his recall exasperates him - the theft of material from the construction site of Clarendon's embarrassingly sumptuous new house just north of Piccadilly.

In the dilapidated surroundings of the Savoy hospital, a delegation from the Netherlands has gathered for a final attempt to secure peace between the two nations. Thomas Chaloner, active in Holland during Cromwell's time, knows many of the delegates, including the sister of his late wife. Then the body of his former brother-in-law is found in the Thames. Chaloner discovers that the dead man has left enigmatic clues to a motivation for his murder.

1664. There is an electric air of foreboding on the streets of London. An atmosphere Thomas Chaloner fears will only take a small spark to ignite into another civil war.... Thomas Chaloner has forged a living as spy to the Lord Chancellor, the Earl of Clarendon, since the early days of the Restoration. Now, in February 1664, he is aware of an undercurrent of restlessness on the streets of London. The coffee houses are thick with rumours. There is anger at the new laws governing church attendance and a deepening contempt for the loucheness of the court. And there is murder. 

Having just returned from a clandestine excursion to Spain and Portugal on behalf of the queen, Thomas Chaloner finds London dank and grey under leaden skies. He finds many things changed, including the government slapping a tax on printed newspapers. Handwritten news reports escape the duty, and the rivalry between the producers of the two conduits of news is the talk of the coffee houses with the battle to be first with any sort of intelligence escalating into violent rivalry. And it seems that a number of citizens who have eaten cucumbers have come to untimely deaths.

Thomas Chaloner, spy for the King's intelligence service, has just returned from thwarting a planned revolt in Dublin, but soon realises that England's capital is no haven of peace. He is ordered to investigate the shooting of a beggar during a royal procession. He soon learns the man is no vagrant, but someone with links to the powerful company of Barber-Surgeons. His master, the earl of Clarendon, is locked in a deadly feud with the earl of Bristol, and an innocent man is about to be hanged in Newgate. 

harles II is well established at White Hall Palace, his mistress at hand in rooms over the Holbein bridge, the heads of some of the regicides on public display. London seethes with new energy, freed from the strictures of the protectorate, but many of its inhabitants have lost their livelihoods. One is Thomas Chaloner, a reluctant spy for the feared secretary of state, John Thurloe, and now returned from Holland in desperate need of employment. 

In 1360, the Great Bridge over the River Cam is close to collapse. To repair it will cost the town and the University dear, especially if its rotten wood is replaced by more durable stone. As arguments rage over raising the money other, equally heated, differences are coming to the boil over the election of a new chancellor. While the majority support Brother Michael for the post, at least one of his opponents aims to seize it by fair means or foul. Then the discovery of a body under the bridge and the disappearance of two scholars throws a more sinister shadow over both disputes.

Believers in the theory of nominalism have set some Cambridge colleges at the throats of those who believe them to be heretics, and Michael, the senior proctor, has his work cut out to keep the peace. When a nominalist is murdered during a riot, Michael is certain he will easily find the killer amongst the Dominicans, but before he can get any sense out of them his junior proctor, Walcote, is found hanged, and he discovers that his trusted ally had arranged secret meetings at the St Ragelund Convent....

Matthew Bartholomew doesn't want to travel to Peterborough in the summer of 1358, but his friendship with the lovely Julitta Holm has caused a scandal in Cambridge, so he has no choice. He is one of a party of Bishop's Commissioners, charged to discover what happened to Peterborough's abbot, who went for a ride one day and has not been seen since. When the Commissioners arrive, they find the town in turmoil.

In the sapping summer heat of 1665, there is little celebration in London of the naval victory at the Battle of Lowestoft. The King, his retinue and anyone with sufficient means has fled the plague-ridden city, its half-deserted streets echoing the sound of bells tolling the mounting number of deaths. Those who remain clutch doubtful potions to ward off the relentless disease and dart nervously past shuttered buildings, watchful for the thieves who risk their lives to plunder what has been left behind.

Identifying the murderer of the Chancellor of the university is not the only challenge facing physician Matthew Bartholomew. Many of his patients have been made worse by the ministrations of a 'surgeon' recently arrived from Nottingham, his sister is being rooked by the mason she has commissioned to build her husband's tomb and his friend, Brother Michael, has been offered a bishopric which will cause him to leave Cambridge.

Cambridge, 1354. Christmas approaches, and the town is gripped by the worst blizzards in living memory. As the physician Matthew Bartholomew struggles to help the poorer citizens cope with freezing temperatures, his colleagues prepare for the festivities. The weather has trapped many travellers in the town, including Matthew's erstwhile love, Philippa. She and her wealthy husband are invited to Michaelhouse for the main feast, and Matthew is horrified that he does not immediately recognise the overweight, sulky woman who once stole his heart.

In the summer of 1358 the physician Matthew Bartholomew returns to Cambridge to learn that his beloved sister is in mourning after the unexpected death of her husband, Oswald Stanmore. Aware that his son has no interest in the cloth trade that made his fortune and reputation, Oswald has left the business to his widow, but a spate of burglaries in the town distracts Matthew from supporting Edith in her grief and attempting to keep the peace between her and her wayward son.

In 1358, over a century after its foundation in Cambridge, the college of Michael House is facing a serious shortfall of funds and competition from upstarts rivals such as Zachary Hostel. Their problems are made no easier by the hostility of the town's inhabitants, who favour the university moving away to the Fens. This simmering tension threatens to break into violence when a well-known tradesman is found dead in one of the colleges.

The fourth chronicle of Matthew Bartholomew continues the adventures of the 14th-century Cambridge physician when he is called to attend to two deaths from some poisoned wine. The opening of a new and very well-endowed college has created petty infighting amongst the academics as new appointments are made. The winter and spring have been appallingly wet, there is a fever outbreak amongst the poorer townspeople and the country is not yet fully recovered from the aftermath of the plague.