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Young women are being discovered dead across the Old Town, all having suffered similarly gruesome ends. In the New Town, medical student Will Raven is about to start his apprenticeship with the brilliant and renowned Dr Simpson. Simpson's patients range from the richest to the poorest of this divided city. His house is like no other, full of visiting luminaries and daring experiments in the new medical frontier of anaesthesia.

Edinburgh, 1849. Hordes of patients are dying all across the city, with doctors finding their remedies powerless. And a whispering campaign seeks to paint Dr. James Simpson, pioneer of medical chloroform, as a murderer. Determined to clear Simpson’s name, his protégé Will Raven and former housemaid Sarah Fisher must plunge into Edinburgh’s deadliest streets and find out who or what is behind the deaths. Soon they discover that the cause of the deaths has evaded detection purely because it is so unthinkable.

Dr Will Raven is a man seldom shocked by human remains, but even he is disturbed by the contents of a package washed up at the Port of Leith. Stranger still, a man Raven has long detested is pleading for his help to escape the hangman. Back in the townhouse of Dr James Simpson, Sarah Fisher has set her sights on learning to practise medicine. Almost everyone seems intent on dissuading her from this ambition, but when word reaches her that a woman has recently obtained a medical degree despite her gender, Sarah decides to seek her out.

1854 marks the dawn of a scientific age. Queen Victoria delivers a healthy heir after receiving chloroform during labour. Florence Nightingale makes headlines as she leads a troop of middle-class women out into the war zones as nurses. In Edinburgh, we see Henry Littlejohn appointed as the city's police surgeon, dubbing himself as the 'medical detective', investigating sudden deaths - whether accidental or intentional.

Edinburgh, 1847. Will Raven is a medical student, apprenticing for the brilliant and renowned Dr Simpson. Sarah Fisher is Simpson’s housemaid and has all of Raven’s intelligence, but none of his privileges. As bodies begin to appear across the Old Town, Raven and Sarah find themselves propelled headlong into the darkest shadows of Edinburgh’s underworld. And if either of them are to make it out alive, they will have to work together to find out who’s responsible for the gruesome deaths.