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In 1358, over a century after its foundation in Cambridge, the college of Michael House is facing a serious shortfall of funds and competition from upstarts rivals such as Zachary Hostel. Their problems are made no easier by the hostility of the town's inhabitants, who favour the university moving away to the Fens. This simmering tension threatens to break into violence when a well-known tradesman is found dead in one of the colleges.

The fourth chronicle of Matthew Bartholomew continues the adventures of the 14th-century Cambridge physician when he is called to attend to two deaths from some poisoned wine. The opening of a new and very well-endowed college has created petty infighting amongst the academics as new appointments are made. The winter and spring have been appallingly wet, there is a fever outbreak amongst the poorer townspeople and the country is not yet fully recovered from the aftermath of the plague.

Matthew Bartholomew, doctor of medicine and fellow of Michaelhouse, Cambridge, is travelling with a party from the college to accept the gift of the living of a parish in Suffolk. One of his companions, Unwin, an unworldly scholar, is to be installed as priest. Their journey is not without incident - they are chased by footpads, pass through an eerie village abandoned after the recent plague and find a man barely alive on a gibbet - so they reach their destination with some relief. But their thoughts of recovering while enjoying the local Pentecostal Fair are soon curtailed.

In 1350 the people of Cambridge are struggling to overcome the effects of the Black Death - and with a high mortality rate among priests and monks, the townsfolk are vulnerable to sinister cults that have sprung up. At Michaelhouse, Matthew Bartholomew is training new physicians when the body of a friar is found in the massive chest that the university uses to store precious documents. While investigating, Bartholomew stumbles across a derelict church being used as a meeting place for the mysterious sect he believes is at the heart of a web of blackmail.

The people and businesses of London are quickly recovering from the ravages of the plague, none faster than the Court of Charles II where excess, corruption and debauchery has rebounded at a frenetic pace. In Westminster, in the haphazard corridors of White Hall Palace, plans are afoot for a grandiose ball in honour of a long-dead but English-born Pope. Meanwhile, the markets and coffee houses in the city are awash with rumours of war and portents of a coming disaster, inflamed by uncensored newssheets and the wagging tongues of dissatisfied citizens.

In 1665, England is facing war with the Dutch, and the capital is awash with rumours of conspiracy and sedition. As an experienced investigator, Thomas Chaloner knows that there are very few grains of truth in the shifting sands of the rumour-mill, but the murder of Paul Ferine, a Groom of the Robes, in a brothel favoured by the elite of the Palace of White Hall makes him scent a whiff of genuine treason.

The fourth adventure in the Thomas Chaloner series. Christopher Vine, a Treasury clerk working in solitary piety in the Painted Chamber of the Palace of Westminster, is not alone. A killer waits in the draughty hall to ensure Vine will not live to see in the New Year. And Vine is not the only government official to die that season. The Lord Chancellor fears his enemies will skew any investigation to cause him maximum damage, so he decides to commission his own inquiries into the murders.

In the spring of 1666 everyone's first reaction to a sudden death at the palace of White Hall is that the plague has struck, but the killing of Thomas Chiffinch was by design, not disease. Chiffinch was holder of two influential posts - Keeper of the Closet and Keeper of the Jewels - and rival courtiers have made no secret of their wish to succeed to those offices. To Thomas Chaloner, ordered to undertake the investigation, such avarice gives a whole host of suspects an ample motive for murder.

In 1360 Edward III issues a call to arms, as sporadic attacks by the French threaten to turn into a full-blown invasion. In Cambridge, fear of the enemy is magnified by the belief that foreign agents are lurking in the area. Tension runs ever higher as rumours and ignorance fan the flames of suspicion amid preparations for war. And then the first murder occurs - of a French scholar living in the town.

By January 1666, the plague has almost disappeared from London, leaving its surviving population diminished and in poverty. The resentment against those who had fled to the country turns to outrage as the court and its followers return, their licentiousness undiminished. The death of a well-connected physician, the mysterious sinking of a man-of-war in the Thames and the disappearance of a popular courtier are causing concern to Thomas Chaloner's employer.

Superspy of Restoration London, Thomas Chaloner foils an uprising in his eighth outing. Five years after Charles II's triumphant return to London, there is growing mistrust of his extravagant court and of corruption among his officials - and when a cart laden with gunpowder explodes outside the General Letter Office, it is immediately clear that such an act is more than an expression of outrage at the inefficiency of the postal service. 

Thomas Chaloner is relieved to be summoned back to London. His master, the Earl of Clarendon, has sent him to Tangier to investigate a case of corruption. Chaloner will be glad to be home, to be reunited with his new wife, but the trivial reason for his recall exasperates him - the theft of material from the construction site of Clarendon's embarrassingly sumptuous new house just north of Piccadilly.

In the dilapidated surroundings of the Savoy hospital, a delegation from the Netherlands has gathered for a final attempt to secure peace between the two nations. Thomas Chaloner, active in Holland during Cromwell's time, knows many of the delegates, including the sister of his late wife. Then the body of his former brother-in-law is found in the Thames. Chaloner discovers that the dead man has left enigmatic clues to a motivation for his murder.

1664. There is an electric air of foreboding on the streets of London. An atmosphere Thomas Chaloner fears will only take a small spark to ignite into another civil war.... Thomas Chaloner has forged a living as spy to the Lord Chancellor, the Earl of Clarendon, since the early days of the Restoration. Now, in February 1664, he is aware of an undercurrent of restlessness on the streets of London. The coffee houses are thick with rumours. There is anger at the new laws governing church attendance and a deepening contempt for the loucheness of the court. And there is murder. 

Having just returned from a clandestine excursion to Spain and Portugal on behalf of the queen, Thomas Chaloner finds London dank and grey under leaden skies. He finds many things changed, including the government slapping a tax on printed newspapers. Handwritten news reports escape the duty, and the rivalry between the producers of the two conduits of news is the talk of the coffee houses with the battle to be first with any sort of intelligence escalating into violent rivalry. And it seems that a number of citizens who have eaten cucumbers have come to untimely deaths.

Thomas Chaloner, spy for the King's intelligence service, has just returned from thwarting a planned revolt in Dublin, but soon realises that England's capital is no haven of peace. He is ordered to investigate the shooting of a beggar during a royal procession. He soon learns the man is no vagrant, but someone with links to the powerful company of Barber-Surgeons. His master, the earl of Clarendon, is locked in a deadly feud with the earl of Bristol, and an innocent man is about to be hanged in Newgate. 

harles II is well established at White Hall Palace, his mistress at hand in rooms over the Holbein bridge, the heads of some of the regicides on public display. London seethes with new energy, freed from the strictures of the protectorate, but many of its inhabitants have lost their livelihoods. One is Thomas Chaloner, a reluctant spy for the feared secretary of state, John Thurloe, and now returned from Holland in desperate need of employment. 

In 1360, the Great Bridge over the River Cam is close to collapse. To repair it will cost the town and the University dear, especially if its rotten wood is replaced by more durable stone. As arguments rage over raising the money other, equally heated, differences are coming to the boil over the election of a new chancellor. While the majority support Brother Michael for the post, at least one of his opponents aims to seize it by fair means or foul. Then the discovery of a body under the bridge and the disappearance of two scholars throws a more sinister shadow over both disputes.

February 1355: Oxford explodes in one of the most serious riots of its history. Fearing for their lives, the scholars flee, and some choose the University at Cambridge as their temporary refuge. But they don't remain safe for long. Within hours of their arrival, the first of their number dies, followed quickly by a second. When Matthew Bartholomew begins to investigate the deaths, he uncovers evidence that the Oxford riot was not a case of random violence, but part of a carefully orchestrated plot.

It is not long before they learn that the friary in which they are staying is not the safe haven they imagine - one guest has already been murdered. It soon emerges that the dead man was holding the Hugh Chalice, a Lincoln relic with a curiously bloody history. Bartholomew and Michael are soon drawn into a web of murder, lies and suspicion in a city where neither knows who can be trusted.