Your Checkup: Patient Education Health Podcast copertina

Your Checkup: Patient Education Health Podcast

Your Checkup: Patient Education Health Podcast

Di: Ed Delesky MD and Nicole Aruffo RN
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Ever leave the doctor’s office more confused than when you walked in? Your Checkup: Health Conversations for Motivated Patients is your health ally in a world full of fast appointments and even faster Google searches. Each week, a board certified family medicine physician and a pediatric nurse sit down to answer the questions your doctor didn’t have time to.


From understanding diabetes and depression to navigating obesity, high blood pressure, and everyday wellness—we make complex health topics simple, human, and actually useful. Whether you’re managing a condition, supporting a loved one, or just curious about your body, this podcast helps you get smart about your health without needing a medical degree.

Because better understanding leads to better care—and you deserve both.







© 2026 Your Checkup: Patient Education Health Podcast
Disturbo fisico e malattia Igiene e vita sana Successo personale Sviluppo personale
  • 117: Migraine Explained: Triggers, Treatment, and When to Worry for Patients
    Jun 15 2026

    We break down migraines as a neurologic condition with a real brain-based chain reaction, not a character flaw or a one-off “bad headache.” We share practical prevention habits, how to track triggers, and how acute and preventive migraine medications fit together so you can walk into your next visit prepared.

    • what makes a migraine different from other headache types
    • common and less common migraine presentations including aura and scary look-alikes
    • the five-step migraine chain reaction including CGRP and pain amplification
    • high-yield triggers like stress, sleep changes, skipped meals, hormones, smells, and weather shifts
    • consistency as the core prevention theme across sleep, exercise, eating, and stress
    • migraine diary basics to identify patterns and improve your neurologist visit
    • when headaches warrant a call to a clinician and what red flags to take seriously
    • acute treatment options including OTC meds, triptans, CGRP blockers, and anti-nausea meds
    • medication overuse headache risk when acute meds are used too often
    • preventive options including beta blockers, anti-seizure meds, antidepressants, and Botox

    You can find us on Threads, you could send us an email, or you can send us some fan mail. We still have that voice-based fan mail still waiting for that first fateful one.


    Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.

    Support the show

    Production and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RN

    Artwork Rebrand and Avatars:

    Vantage Design Works (Vanessa Jones)

    Website: https://www.vantagedesignworks.com/

    Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qr


    Original Artwork Concept: Olivia Pawlowski

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    53 min
  • 116: Can Weight Loss Medications (GLP1s) Reduce Breast Cancer Risk?
    Jun 8 2026
    A headline like “weight loss drugs may reduce breast cancer risk” grabs attention fast, but the real story lives in the fine print. We take you through a new Penn Medicine study that observed lower breast cancer rates among women with overweight or obesity who used GLP-1 medications, then we translate what that finding actually means in plain language. Observational data can reveal a signal worth studying, but it cannot prove the medication caused the outcome, and that distinction matters for your decisions and your expectations. We also zoom out to the bigger why: obesity is not just about body size. Fat tissue is biologically active, shaping chronic inflammation, estrogen exposure after menopause, insulin resistance, and even how well the immune system spots abnormal cells. Those pathways help explain why obesity is linked to many cancers, including postmenopausal breast cancer, and why researchers are curious whether effective obesity treatment could shift risk over time. Then we get practical. We review what stronger evidence from randomized controlled trials says so far: GLP-1 drugs like Ozempic, Wegovy, Mounjaro, and Zepbound do not appear to increase breast cancer risk in the available trial data, even though most trials were not designed to study cancer outcomes for many years. We also discuss why newer studies seem most suggestive for hormone receptor positive breast cancer, along with the leading theories: weight loss itself, improved metabolic health and insulin signaling, reduced inflammation, and the still-unclear possibility of direct GLP-1 effects in cancer biology. If you like evidence-based medicine with real-world context (and a little Philly-life banter), subscribe, share this episode with a friend, and leave a review so more people can find the show. What question do you want answered next about GLP-1s, obesity treatment, or cancer risk?ReferencesRisk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists : A Systematic Review and Meta-Analysis. Ko A, Chang YC, Bahar F, et al. Annals of Internal Medicine. 2025;. doi:10.7326/ANNALS-25-02237.Do GLP-1 Receptor Agonists Increase the Risk of Breast Cancer? A Systematic Review and Meta-Analysis. Piccoli GF, Mesquita LA, Stein C, et al. The Journal of Clinical Endocrinology and Metabolism. 2021;106(3):912-921. doi:10.1210/clinem/dgaa891.Glucagon-Like Peptide 1 Receptor Agonists and Cancer Risk: The Good, the Bad and the Unknown. Mannucci E, Dicembrini I. Nature Reviews. Clinical Oncology. 2026;23(6):459-470. doi:10.1038/s41571-026-01135-0.GLP-1 Agonists Are Associated With a Significant Reduction in Breast Cancer Incidence in Women. McDonald ES, Gillis LB, Gabriel P, et al. JCO Oncology Practice. 2026;:101200OP2600485. doi:10.1200/OP-26-00485.GLP-1 therapy and hormone receptor–positive breast cancer risk and survival: A real-world analysis.. Shah Z, Hundal J, Afridi S, et al. Journal of Clinical Oncology. 2026;44(Suppl 16):10548. doi:10.1200/JCO.2026.44.16_suppl.10548.Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer. Tatum KL, Dahman B, Stevenson A, et al. JAMA Network Open. 2026;9(5):e2612133. doi:10.1001/jamanetworkopen.2026.12133.Association of Glucagon-Like Peptide-1 Receptor Agonists With Risk of Cancers-Evidence From a Drug Target Mendelian Randomization and Clinical Trials. Sun Y, Liu Y, Dian Y, et al. International Journal of Surgery (London, England). 2024;110(8):4688-4694. doi:10.1097/JS9.0000000000001514.GLP-1 receptor agonists and breast cancer risk in type 2 diabetes.. Guo Cheng and Amanda Ward. Journal of Clinical Oncology. 2025;43(Suppl 16):10557. doi:10.1200/JCO.2025.43.16_suppl.10557.Glucagon-Like Peptide-1 Analogues and Risk of Breast Cancer in Women With Type 2 Diabetes: Population Based Cohort Study Using the UK Clinical Practice Research Datalink. Hicks BM, Yin H, Yu OH, et al. BMJ (Clinical Research Ed.). 2016;355:i5340. doi:10.1136/bmj.i5340.GLP-1 Receptor Agonists and Cancer: Current Clinical Evidence and Translational Opportunities for Preclinical Research. Valencia-Rincón E, Rai R, Chandra V, Wellberg EA. The Journal of Clinical Investigation. 2025;135(21):e194743. doi:10.1172/JCI194743.Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.Support the showProduction and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RNArtwork Rebrand and Avatars:Vantage Design Works (Vanessa Jones) Website: https://www.vantagedesignworks.com/Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qrOriginal Artwork Concept: Olivia Pawlowski
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    26 min
  • 115: Are Food Preservatives Raising Your Blood Pressure? A New Study Explained
    Jun 1 2026

    That scary nutrition headline about preservatives and high blood pressure is everywhere right now and it’s easy to jump straight from “linked” to “proven.” We slow it down and do what we’d do in an exam room: look at what the study actually says, what it doesn’t say, and how to translate it into real-life choices that protect your heart without turning grocery shopping into a panic spiral.

    We talk through a new European Heart Journal paper using data from the NutriNet-Santé cohort (over 112,000 adults followed for nearly eight years) that finds several common food preservatives are associated with a higher risk of developing hypertension and cardiovascular disease. We explain why that word “associated” matters, how observational nutrition research can be confounded by overall ultra-processed food intake, sodium, fiber, lifestyle, and other factors, and why the results are best viewed as a signal not a verdict.

    Then we get practical by walking through a typical kitchen day and pointing out where you might run into additives like sodium nitrite, potassium sorbate, phosphoric acid, citric acid, and calcium propionate: breads, deli meats, chips, frozen meals, and even cola beverages. We also share the habits with the strongest evidence for blood pressure control: more minimally processed foods, more fruits and vegetables, less excess sodium, regular activity, better sleep, and stress management.

    If you found this helpful, subscribe, share it with a friend or neighbor, and leave a review so more people can find clear, patient-centered health info. What’s the first preservative you spot when you check five labels in your kitchen?

    Send us a (voice ) message with this link, we would love to hear from you. Standard message rates may apply.

    Support the show

    Production and Content: Edward Delesky, MD, DABOM & Nicole Aruffo, RN

    Artwork Rebrand and Avatars:

    Vantage Design Works (Vanessa Jones)

    Website: https://www.vantagedesignworks.com/

    Instagram: https://www.instagram.com/vantagedesignworks?igsh=aHRuOW93dmxuOG9m&utm_source=qr


    Original Artwork Concept: Olivia Pawlowski

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    27 min
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