Your Brain On copertina

Your Brain On

Your Brain On

Di: Drs. Ayesha and Dean Sherzai
Ascolta gratuitamente

A proposito di questo titolo

 A podcast about the neuroscience of everything. From neurologists, researchers, and public health advocates Drs. Ayesha and Dean Sherzai, explore every aspect of our world through a neuroscientific lens, with science-based stories, interviews, anecdotes, and brain health facts. Equip yourself with neurologically sound answers to life's everyday health questions and learn the essentials of brain health and optimization, one topic at a time.2024 Igiene e vita sana Scienza
Episodi
  • Your Brain On... Vascular Dementia

    Your Brain On... Vascular Dementia
    Feb 4 2026
    Most people think dementia starts with memory loss. But for millions, it actually begins decades earlier: in the blood vessels. Long before someone forgets a name or misses an appointment, the brain is being quietly damaged by high blood pressure, cholesterol imbalance, poor sleep, inflammation, and chronic stress, day after day, year after year. This kind of damage doesn't look dramatic. There's no big stroke, no clear warning sign. It happens slowly and silently, which is why it's so often missed until it's too late. But here's the good news: vascular dementia is one of the most preventable and manageable forms of cognitive decline. When caught early, lifestyle changes and medical interventions can help slow the onset and manage the effects. In this episode, we explore: What vascular dementia and vascular cognitive impairment are, and how they differ from Alzheimer's diseaseWhy most dementia cases involve both vascular damage and neurodegenerative pathology (mixed dementia)How blood vessel damage begins in childhood and accumulates silently for decadesThe role of high blood pressure, cholesterol, diabetes, sleep disorders, and chronic stress in damaging brain vasculatureWhy slowed thinking, movement, and processing speed are hallmark signs of vascular cognitive declineThe critical importance of the endothelium: the thin lining of blood vessels that controls brain healthHow lifestyle factors like nutrition, exercise, sleep, and stress management protect and repair vascular healthWhy managing blood pressure early is one of the most powerful interventions for long-term brain health (and why everyone should have a blood pressure monitor at home!)How vascular damage can be slowed, even in midlifePractical steps for prevention across the lifespan, from childhood through older adulthood Our guest for this episode is DR. COLUMBUS BATISTE, a board-certified interventional cardiologist, an incredible science communicator, and author of 'Selfish: A Cardiologist's Guide to Healing a Broken Heart'. Dr. Batiste brings deep expertise on how cardiovascular health shapes brain health, and why protecting the endothelium (the inner lining of blood vessels) is foundational to longevity. His work emphasizes that all roads to longevity are paved by the heart, and what's good for the heart is good for the brain! 'Your Brain On…' is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai. SUPPORTED BY: NEURO World, a science-based brain health community designed to help you protect your brain long before problems begin. Learn more at https://neuro.world/ 'Your Brain On… Vascular Dementia' • SEASON 6 • EPISODE 8 ——— LINKS Dr. Columbus Batiste: https://drbatiste.com/ Instagram: @HeartHealthyDoc Facebook: https://www.facebook.com/drbatiste ——— FOLLOW US Join NEURO World: https://neuro.world/ Instagram: https://www.instagram.com/thebraindocs YouTube: https://www.youtube.com/thebraindocs ——— REFERENCES Core Definitions & Diagnostic Framework • Diagnostic and Statistical Manual of Mental Disorders (5th ed.) - American Psychiatric Publishing • Vascular contributions to cognitive impairment and dementia - https://doi.org/10.1161/STR.0b013e3182299496 • Classifying neurocognitive disorders: The DSM-5 approach - https://doi.org/10.1038/nrneurol.2014.181 Epidemiology & Public Health Burden • Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease - https://doi.org/10.1007/s00401-016-1571-z • Vascular dementia - https://doi.org/10.1016/S0140-6736(15)00463-8 • Risk reduction of cognitive decline and dementia: WHO guidelines - WHO Press Small Vessel Disease & Subcortical Vascular Dementia • Small vessel disease: Mechanisms and clinical implications - https://doi.org/10.1016/S1474-4422(19)30079-1 • Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges - https://doi.org/10.1016/S1474-4422(10)70104-6 • The clinical importance of white matter hyperintensities on brain magnetic resonance imaging - https://doi.org/10.1136/bmj.c3666 Mixed Dementia & Alzheimer–Vascular Overlap • Mixed brain pathologies account for most dementia cases in community-dwelling older persons - https://doi.org/10.1212/01.wnl.0000271090.28148.24 • Early role of vascular dysregulation on late-onset Alzheimer's disease - https://doi.org/10.1016/j.neurobiolaging.2016.04.009 • The pathobiology of vascular dementia - https://doi.org/10.1016/j.neuron.2013.10.008 Cerebral Amyloid Angiopathy (CAA) • Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways - https://doi.org/10.1038/s41582-019-0281-2 • Emerging concepts in sporadic cerebral amyloid angiopathy - https://doi.org/10.1093/brain/awx047 Genetics, Inflammation, and Repair • Apolipoprotein E controls cerebrovascular integrity via cyclophilin A - https://doi.org/...
    Mostra di più Mostra meno
    1 ora e 22 min
  • Your Brain On... Cold Plunges

    Your Brain On... Cold Plunges
    Jan 21 2026
    Cold plunges are everywhere, and the way people talk about them, you'd think they're a miracle cure for your brain, body, and soul. But in an age of algorithm-fueled evangelism, when a ritual becomes this ubiquitous and loud, we have to ask: how much of the buzz is backed by science… and how much is just marketing? In this episode, we explore the neuroscience of cold exposure: what's real, what's overstated, and why this "discomfort" has become a billion-dollar industry. We discuss: Why cold plunges went viral, and how wellness movements often devolve into identity-driven culturesThe difference between cold exposure itself and the monetized "cold plunge movement"What constitutes a "cult" (and how pseudoscience forms around partial truths)The real physiological cold shock responseWhy the mental "high" after a plunge doesn't automatically equal long-term brain benefitThe cardiovascular risks that rarely get discussed, especially for people with underlying heart diseaseWhat the research suggests about soreness, pain reduction, and muscle growth (including why cold immersion can blunt hypertrophy)The real story behind brown fatWho should avoid cold plunges altogether (asthma, arrhythmias, coronary disease, vascular conditions) Joining us for this conversation is investigative journalist and bestselling author Scott Carney (What Doesn't Kill Us, The Wedge), who has spent years inside the cold exposure world, first as a skeptic, then as a believer, and eventually as a critic of the culture that formed around it. His work reveals what happens when discomfort becomes identity, and when unfounded "social media science" outruns real science. Your Brain On... is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai. SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: neuroworldretreat.com Your Brain On... Cold Plunges • SEASON 6 • EPISODE 7 REFERENCES Cold Water Immersion, Muscle Adaptation, and Recovery Roberts, L. A., Raastad, T., Markworth, J. F., Figueiredo, V. C., Egner, I. M., Shield, A., Cameron-Smith, D., Coombes, J. S., & Peake, J. M. (2015). Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training. Journal of Physiology, 593(18), 4285–4301. https://doi.org/10.1113/JP270570 Bleakley, C. M., McDonough, S. M., & MacAuley, D. C. (2004). The use of ice in the treatment of acute soft-tissue injury: A systematic review of randomized controlled trials. American Journal of Sports Medicine, 32(1), 251–261. https://doi.org/10.1177/0363546503260757 Leeder, J., Gissane, C., van Someren, K., Gregson, W., & Howatson, G. (2012). Cold water immersion and recovery from strenuous exercise: A meta-analysis. British Journal of Sports Medicine, 46(4), 233–240. https://doi.org/10.1136/bjsports-2011-090061 White, G. E., & Wells, G. D. (2013). Cold-water immersion and other forms of cryotherapy: Physiological changes potentially affecting recovery from high-intensity exercise. Sports Medicine, 43(8), 695–706. https://doi.org/10.1007/s40279-013-0055-8 Kellmann, M., Bertollo, M., Bosquet, L., Brink, M., Coutts, A. J., Duffield, R., Erlacher, D., Halson, S. L., Hecksteden, A., Heidari, J., Kölling, S., Meyer, T., Mujika, I., Robazza, C., Skorski, S., Venter, R., & Beckmann, J. (2018). Recovery and performance in sport: Consensus statement. International Journal of Sports Physiology and Performance, 13(2), 240–245. https://doi.org/10.1123/ijspp.2017-0759 Inflammation, Pain, and Perceived Recovery Hohenauer, E., Taeymans, J., Baeyens, J. P., Clarys, P., & Clijsen, R. (2015). The effect of post-exercise cryotherapy on recovery characteristics: A systematic review and meta-analysis. PLoS ONE, 10(9), e0139028. https://doi.org/10.1371/journal.pone.0139028 Costello, J. T., Culligan, K., Selfe, J., & Donnelly, A. E. (2012). Muscle, skin and core temperature after –110°C cold air and 8°C water treatment. PLoS ONE, 7(11), e48190. https://doi.org/10.1371/journal.pone.0048190 Brown Adipose Tissue (BAT) – Human Imaging & Metabolism van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. (2009). Cold-activated brown adipose tissue in healthy men. New England Journal of Medicine, 360(15), 1500–1508. https://doi.org/10.1056/NEJMoa0808718 Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N. J., Enerbäck, S., & Nuutila, P. (2009). Functional brown adipose tissue in healthy adults. New England Journal of Medicine, 360(15), 1518–1525. https://doi.org/10.1056/NEJMoa0808949 Betz, M. J., & Enerbäck, S. (2015). Human brown adipose tissue: What we have learned so far. Diabetes, 64(7), 2352–2360. https://doi.org/10.2337/db15-0146 Autonomic Nervous System, HRV, and Cold Exposure Mourot...
    Mostra di più Mostra meno
    47 min
  • Your Brain On... Cheese

    Your Brain On... Cheese
    Jan 14 2026

    Around the start of 2026, a study sparked viral headlines claiming that cheese could reduce dementia risk.

    But... nutrition science almost never works like this. One study can't "prove" a food is protective or harmful, and viral health claims often miss the most important details of research: how the data was gathered, what was actually measured, what variables were controlled for, and what it means in real life.

    In this episode, we unpack what the 'viral cheese study' (PMID: 41406402) actually found, what it DOESN'T mean, and why critical thinking around nutrition headlines matters more than ever.

    We discuss:

    • Why viral food headlines are so persuasive (and so often misleading)

    • What the cheese study REALLY reported

    • The difference between correlation and causation in nutrition research

    • Why long-term dietary recall data can be unreliable

    • How bias (including our personal food preferences) shapes interpretation of research

    • What "show me the data" really means in a world of clickbait science

    • How to interpret food and brain health studies without falling into extremes

    We also speak to Emily Sonestedt, research group leader and associate professor at Lund University, and one of the authors of the viral study.

    "Your Brain On..." is hosted by neurologists, scientists, and public health advocates Drs. Ayesha and Dean Sherzai.

    SUPPORTED BY: the 2026 NEURO World Retreat. A 5-day journey through science, nature, and community, on the California coastline: https://www.neuroworldretreat.com/

    'Your Brain On... Cheese' • SEASON 6 • EPISODE 6

    ———

    LINKS

    The study, 'High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence From a 25-Year Prospective Cohort Study': https://pubmed.ncbi.nlm.nih.gov/41406402/

    ———

    FOLLOW US

    Join NEURO World: https://neuro.world/

    Instagram: https://www.instagram.com/thebraindocs

    YouTube: https://www.youtube.com/thebraindocs

    More info and episodes: TheBrainDocs.com/Podcast
    Mostra di più Mostra meno
    43 min
Ancora nessuna recensione