Glioblastoma multiforme (GBM) is one of the hardest cancers in the world to treat — not just because it grows fast, but because it spreads like hidden tentacles throughout the brain and hides behind the blood–brain barrier.

In this episode of Outsmart Cancer, Dr. Dino Prato, founder of Envita Medical Centers, explains why GBM keeps coming back even after surgery, radiation, and temozolomide — and how deep multi-omics mapping, smart drug delivery, and immune-centric therapy can change the fight. Using the story of a patient we’ll call Tom, Dr. Prato breaks down how DNA sequencing, RNA transcriptomics, immune spatial biology, and targeted immunotherapy work together to overcome resistance, penetrate the blood–brain barrier, and awaken the body’s natural killer cells.

You’ll learn how strategies like genetically targeted fractionated chemotherapy (GTF), AAIT cellular biologics, oncolytic viruses, methylene blue mitochondrial support, and phytotherapeutics help turn a cold, invisible GBM into a hot, immune-responsive target — all while improving quality of life and real-time monitoring with CTCs and methylation scores.

🎯 What You’ll Learn in This Episode:
• Why GBM returns even after surgery, radiation & temozolomide
• How DNA, RNA & immune spatial biology reveal hidden tumor pathways
• Why the blood–brain barrier blocks many standard drugs
• How microdosed, genetically targeted chemo activates DAMP signaling
• The role of NK cells, dendritic cells & AAIT in immune-centric GBM care
• How mitochondrial repair (cytochrome C, methylene blue, vitamin C) restores apoptosis
• Why gut health plays a critical role in brain-immune function

📍 Envita Medical Centers – Scottsdale, AZ
🌐 Learn more: www.envita.com
📞 Speak to a care coordinator: 866-830-4576

Disclaimer
This podcast is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your licensed healthcare provider before making any medical decisions. Individual results will vary, and Envita Medical Centers does not guarantee outcomes. Some treatments discussed may not be FDA-approved or available in all locations. Testimonials are shared with patient consent and may not reflect typical results. Do not delay or disregard professional medical care based on the podcast's content. Certain treatments may be available only at Envita’s international clinic in Hermosillo, Mexico. No specific outcomes are promised or implied.
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Outcomes Disclaimer
The results referenced from Envita's Precision Cancer Care: 35-Fold Improvement in Response Rates are from a retrospective analysis of 199 late-stage cancer patients treated at Envita Medical Centers between 2021 and 2023, as published in the Journal of Cancer Therapy. These outcomes are not guaranteed and will vary based on individual factors such as cancer type, stage, genetics, immunity and prior treatments. Any comparisons to standard care or clinical trials are based on published data and internal analysis, not head-to-head studies. Individual results will vary.

You can read the full peer-reviewed study at:

https://www.scirp.org/journal/paperinformation?paperid=132493