Episode Description

Title: Scleroderma – Understanding a Complex Autoimmune Disease Series: Talking in the Woods – Science Behind the Script: From Lab to Life

Scleroderma is a rare autoimmune disease that hardens skin and can damage internal organs—but what causes it, and how is it treated? In this episode, host Christopher Wood breaks down the science behind scleroderma, from symptoms and diagnosis to cutting-edge therapies and clinical trials.

You’ll learn:

✔ Common symptoms like Raynaud’s phenomenon, lung fibrosis, and digestive issues

✔ Why genes like STAT4 and IRF5 matter—and how environment triggers disease

✔ How doctors diagnose scleroderma using ANA tests and autoantibody profiles

✔ Breakthrough treatments: stem cell transplants, biologics like Tocilizumab and Rituximab, and small molecules like Nintedanib

✔ The future of therapy: JAK inhibitors, TYK2 inhibitors, and precision medicine

✔ The science behind biologics vs small molecules—with real-world examples and a simple analogy: Biologics are custom-made keys; small molecules are universal tools

✔ Lifestyle tips to reduce flares and improve quality of life

Plus, hear Maria’s inspiring story—how a clinical trial gave her hope and improved her lung function by 20%.

• Resources Mentioned
  • Scleroderma Foundation: https://www.scleroderma.org
  • Clinical Trials: https://clinicaltrials.gov
  • SCOT Trial Publication: New England Journal of Medicine

  References

  1. Maria’s Story – Stem Cell Transplant Trial SCOT Trial: “Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.” Published in New England Journal of Medicine, 2018. Read the full article: https://www.nejm.org/doi/full/10.1056/NEJMoa1703327
  2. Future Therapies & Precision Medicine Varga J, et al. “Emerging Therapies for Systemic Sclerosis: Targeting Pathogenic Pathways.” Published in Nature Reviews Rheumatology, 2023. Read the full article: https://www.nature.com/articles/nrrheum.2023.XX

🎧 Listen now to understand the science, the stories, and the future of scleroderma treatment. Subscribe on Apple Podcasts, Spotify, YouTube, Pandora, or your favorite platform, and join us for Episode 5 on Myositis—coming soon!

Title: Understanding Lupus – Demographics, Diagnosis, and Breakthrough Treatments

Episode Summary: Lupus is one of the most complex autoimmune diseases—but science is changing the game. In this episode of Talking in the Woods, host Christopher Wood explains lupus in plain language: what it is, who it affects, and how doctors diagnose it. Plus, we explore cutting-edge treatments that offer hope for patients.

What You’ll Learn in This Episode:

• What lupus is and how it affects the body
• Key demographics and why ethnicity matters in treatment
• How lupus is diagnosed: ANA, anti-dsDNA, and anti-Smith tests
• SLEDAI scoring and why it’s important
• Breakthrough therapies: CAR T-cell therapy, B-cell targeting drugs, and clinical trial pipeline
• Lifestyle tips to reduce flares and improve quality of life
• Real patient story: Sierra’s journey to remission

Resources Mentioned

• Lupus Foundation of America: https://www.lupus.org
• Clinical Trials: https://clinicaltrials.gov
• CAR T-cell Therapy Case Study: Nature Medicine

References

1. Patient Story – Sierra’s Journey to Remission Case Study: “CAR T-Cell Therapy in Refractory Systemic Lupus Erythematosus.” Published in Nature Medicine, 2022. Read the full article: https://www.nature.com/articles/s41591-022-02073-9
2. Podcast Series Reference Talking in the Woods – Science Behind the Script: From Lab to Life. Explore all episodes:
3. Future Therapies & Clinical Pipeline Fanouriakis A, et al. “Update on the Management of Systemic Lupus Erythematosus.” Published in Annals of the Rheumatic Diseases, 2023. Read the full article: https://ard.bmj.com/content/early/2023

🎧 Listen now to explore lupus from symptoms to science—and discover the future of treatment.

Title: Inside Clinical Trials – What Happens After the Lab?

Episode Summary: Clinical trials are the bridge between discovery and real-world treatments—but what really happens during these studies? In this episode of Talking in the Woods, host Christopher Wood breaks down the phases of clinical trials and why they matter for drug development.

What You’ll Learn in This Episode:

• Phase I: Safety and tolerability in healthy volunteers
• Phase II: Finding the right dose and measuring early effectiveness
• Phase III: Large-scale confirmation and global studies
• Why trials fail and what biomarkers reveal about disease activity
• The importance of patient participation and diversity in research

Resources Mentioned

• FDA Clinical Research Overview: https://www.fda.gov/patients/drug-development-process/step-3-clinical-research
• NIH Inclusion Policy: https://grants.nih.gov/policy/inclusion
• Clinical Trials Database: https://clinicaltrials.gov

References

1. Clinical Trial Phases Explained FDA: “Step 3: Clinical Research.” Available at: https://www.fda.gov/patients/drug-development-process/step-3-clinical-research
2. Why Trials Fail & Biomarkers Matter Ioannidis JPA. “Why Most Clinical Research Is Not Useful.” Published in PLoS Medicine, 2016. Read the full article: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002049
3. Patient Participation & Diversity in Research NIH: “Inclusion of Women and Minorities in Clinical Research.” Available at: https://grants.nih.gov/policy/inclusion

🎧Subscribe on Apple Podcasts, Spotify, or your favorite platform.

🎧 Tune in to discover how clinical trials shape the future of medicine.