Midlife isn’t a crisis—it’s a calling. In this episode, New York Times bestselling author and Modern Elder Academy founder Chip Conley sits down with host Alexia Brue to reframe aging as a powerful phase of reinvention. Drawing from his work with Airbnb and MEA, Chip explores how emotional resilience, community, and “life literacy” can become the true metrics of a long, meaningful life. With wit and wisdom, he challenges conventional career arcs and invites listeners to consider what a purposeful second (or third) act could look like.

Beth McGroarty of the Global Wellness Institute also joins the conversation to share data on the demographic shifts driving this reframing of midlife. She unpacks how aging boomers are rejecting traditional retirement, how longevity is reshaping work itself, and why we need bold new models for connection, housing, and purpose in later life.

Inside this Episode:

• Why wisdom—not youth—may be the most undervalued longevity asset
• Emotional, cognitive, and social well-being as pillars of healthspan
• New rites of passage: why we need a midlife curriculum
• The Modern Elder Academy and the future of multi-generational living
• Beth McGroarty: Rise of “Don’t-Call-It-Senior-Living” concepts like Mather, the wellness industry’s opportunity to support older workers, and the economic imperative to reimagine purpose after 60
• Why longevity solutions must go beyond biology to meaning, contribution, and community

Resources Mentioned:

• Modern Elder Academy
• Global Wellness Institute
• Mather Institute

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

What if your skincare routine could go beyond aesthetics and actually slow aging at the cellular level?

In this episode of The Wellness Roundtable: Longevity, Alexia Brue sits down with Carolina Oliveira, MD / co-founder and CEO of OneSkin, a biotech company on a mission to transform skin from a cosmetic afterthought to a longevity biomarker.

Dr. Oliveira shares how her team of scientists developed OS-01, the first topical peptide shown to reduce the burden of senescent cells in skin. We explore the clinical validation behind the product, why “skinspan” matters for your healthspan, and how your skin’s biological age may be a bellwether for systemic inflammation and immune health.

This is not your average skincare chat—it’s a science-backed conversation about the future of personalized longevity, from barrier function to bioinformatics.

This episode also features insights from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute.

Inside This Episode:

• Why skin is more than cosmetic: it’s a modifiable aging organ
• The role of senescent cells in driving systemic inflammation
• How OneSkin developed and validated its OS-01 peptide
• The surprising link between topical products and internal biomarkers
• What most longevity enthusiasts overlook about skin health
• How OneSkin is earning credibility with leaders like David Sinclair and Peter Diamandis
• Daily protocols: How Dr. Oliveira approaches her own longevity stack

Resources & Mentioned:

• OneSkin’s OS-01 peptide
• Mentions: David Sinclair, Peter Diamandis, Bryan Johnson
  
  

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors
To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch
Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!

Short Summary:
Women may live longer—but they spend more of those years in poor health. In this essential conversation, Piraye Beim, MD & founder of Celmatix, reveals why ovarian aging is the hidden accelerant of female biological decline—and why extending ovarian healthspan could be the next major breakthrough in longevity science. From inflammaging to AMH biomarkers, Dr. Beim brings cutting-edge reproductive science into the center of the longevity discourse.

This episode also features insights from Beth McGroarty, VP of Research & Forecasting at the Global Wellness Institute.

Inside this episode:

• The “gonadal gap”: why menopause accelerates aging for women
• Why ovarian function is a key regulator of brain, bone, and metabolic health
• How tracking AMH levels could transform preventive care for women in their 30s and 40s
• The underfunding of female longevity research—and how that’s starting to change
• ARPA-H and other public-private partnerships funding therapeutic innovations
• The potential to delay menopause and extend healthspan through new medical approaches

Resources Mentioned:

• Celmatix
  
  
• ARPA-H research on ovarian aging
  
  
• Global Wellness Institute

Hosted by: Alexia Brue, co-founder of Well+Good; founder of a new healthspan training studio, The Practice; member of the Global Wellness Institute Board of Advisors

To learn more about the Global Wellness Institute please visit us at global wellness institute.org, connect with us on Instagram and subscribe to our YouTube channel.

Produced by: Emily Roberts and Ali Alquiza of Over Lunch

Music provided by: Myndstream

Thank you to our sponsor, Fountain Life, for supporting the GWI Podcast. Head to FountainLife.com to learn more.

Subscribe, rate, & review wherever you listen to podcasts!