The Longevity Vault with Kat Fu copertina

The Longevity Vault with Kat Fu

The Longevity Vault with Kat Fu

Di: Kat Fu M.S. M.S.
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A proposito di questo titolo

 The Longevity Vault by Kat Fu — the longevity platform that guides you to build your personalized roadmap, based on your risk factors and your data, so you can age slower, think better, and extend your prime. Its flagship, Sleep OS, helps you reduce 3 a.m. wake-ups so you can sleep through the night—even if you've mastered sleep hygiene.

thelongevityvault.substack.comKat Fu Disturbo fisico e malattia Igiene e vita sana
Episodi
  • Why ‘Sleep Hygiene’ Doesn’t Fix 3 a.m. Wake-Ups

    Why ‘Sleep Hygiene’ Doesn’t Fix 3 a.m. Wake-Ups
    Feb 21 2026

    ➤ Someone recently asked me this question, and it captures a pattern I see constantly:

    “I have no trouble falling asleep. I’m out within minutes. But I wake up at 3 a.m.—sometimes to pee, sometimes for no reason—and I can’t get back to sleep. I drift in and out until 5 a.m. and nothing I’ve tried fixes it.”

    They’d tried melatonin. Magnesium. No screens. No caffeine.

    Nothing worked.

    Here’s what I told them: falling asleep and staying asleep are different problems.

    The Opposite Pattern

    If someone has difficulty falling asleep but then sleeps deeply and continuously for seven to eight hours, a circadian or timing-related adjustment can often resolve the issue entirely. The fix tends to be relatively contained.

    Staying asleep is more complex.

    Why Staying Asleep Is Harder to Solve: The challenge with early wakeups or shortened sleep is that there is not a single cause or a single solution.

    In the individuals I work with, difficulty staying asleep is usually related to being in a lighter-than-ideal sleep state during a specific window—and therefore more vulnerable to disruption from various things: bathroom trips, thoughts, a noise outside, pain, or dreams that wake the individual and keep them awake.

    During sleep, your brain cycles through 80- to 120-minute ultradian cycles. At the end of each cycle—and during transitions between sleep stages—the brain has brief arousals on the order of seconds to minutes. Many of these aren’t remembered.

    It is during these moments that you become vulnerable to triggers that can turn a brief, normal arousal into sustained wakefulness and alertness.

    The problem is being easily woken—and then unable to fall back asleep.

    It’s not the drinking too much water. It’s typically not the life responsibilities causing the thinking. It’s not the dreaming.

    * If you pop awake briefly and fall back asleep fast, that often fits typical sleep architecture.

    * If your awakenings are long, frequent, and leave you feeling wired and alert, then something is amplifying what should be a normal sleep transition into sustained wakefulness.

    Why This Changes What You Do Next

    If your solutions target the triggers—drink less water, block noise, meditate before bed—instead of the internal state that’s amplifying them, you’ll keep cycling through partial fixes. The trigger changes. The wakeup stays.

    This distinction is the foundation of how I approach sleep work. Falling asleep and staying asleep need different investigations, different timelines, and different tools.

    Warmly,

    —Kat

    P.S. If your sleep has changed since midlife and you want a structured, mechanism-based approach to addressing your sleep, here’s how I help.



    This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit thelongevityvault.substack.com/subscribe
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    3 min
  • “My friend the same age sleeps fine—why am I the one awake at 3 AM?”

    “My friend the same age sleeps fine—why am I the one awake at 3 AM?”
    Feb 20 2026
    This is a free preview of a paid episode. To hear more, visit thelongevityvault.substack.com➤ “Every morning my body kicks me awake between 2:30–3:30 am. No matter what I do—no screens, peppermint tea, chamomile tea—I still wake up. Then I drift in and out until ~5:30 am, when I finally give up and get out of bed.It has been years of this.My doctor says it’s normal for my age, but I’m exhausted. Why isn’t anything working?”This is a question I’m most often asked — in many variations, but always with the same frustration behind it.They’d followed every piece of advice: good sleep hygiene, clean diet, regular yoga & meditation.Yet, the 3 AM wake-ups persisted.Why Standard Midlife Sleep Advice Brings Only Partial ReliefThe conventional wisdom around hormones and sleep in mid life & later decades contains solid science.Estrogen does support GABA function. Testosterone supports slow wave sleep. And, declining hormone levels do contribute to sleep disruption during mid-life, perimenopause and beyond.These insights have helped many understand why their sleep changed.But, if hormones fall for virtually all adults after 50, why do sleep outcomes differ widely?Hormones are one contributor to sleep quality — other systems also matter — but their decline in midlife often becomes the tipping point that turns occasional wake-ups into a regular 3 AM pattern.Some >50 Sleep Fine, Others Have More Challenges: What Makes the Difference?Most mid-life adults experience a decline in estrogen, progesterone, or testosterone production.This is expected biology.However, some continue to enjoy 7–8 hour nights. Others develop a 3 AM wake-up pattern that persists for years.A question I was recently asked captures this contrast:I’ve been waking at 2 or 3 AM since perimenopause, but my friend the same age sleeps like a baby. We both have lower estrogen—why am I the one staring at the ceiling?(Men: While this example focuses on a woman’s experience, the same dynamics apply with age-related testosterone decline and sleep disruption.)The difference isn’t just hormone levels.It can reflect how well the body keeps each part of the hormone process working — from hormone production to transport, receptor response, and clearance.For some, those pathways remain supported enough to stabilize sleep. For others, gaps in support can make the natural decline more disruptive.The Resignation Factor: You Don’t Need to Accept “Normal for Your Age”Instead of exploring why these differences exist, we are often encouraged to accept them.“I’m 65 — of course my estrogen is low.” Or: “My testosterone just isn’t what it used to be.”Healthcare providers often reinforce this acceptance with phrases like “normal for your age.”I’ve heard these phrases from my own doctors too.However, this resignation overlooks something important: the body continues hormone production throughout life.The reproduction axis may slow, but the* adrenal glands,* fat tissue,* muscle,* brain tissue,maintain capacity for production or conversion of hormones.The question is not whether your body can still produce and use hormones — it can.The question is whether these remaining pathways are receiving the support they need to function well.The Turkey & Tryptophan Problem: Why Incomplete Advice Leaves You Awake at 3 AMConsider the common advice: “eat turkey for better sleep because turkey contains tryptophan.”Technically accurate. Turkey does contain tryptophan, and tryptophan is required for melatonin synthesis.But this advice misses the other steps required for tryptophan conversion: the helpers that allow the body to transform tryptophan into melatonin. Without these pieces in place, the tryptophan remains un-used for melatonin synthesis.The same partial approach applies to hormone support more broadly.The advice “get morning sunlight and exercise” provides useful health benefits but doesn’t address whether your body has the resources required specifically for hormone synthesis and function.A useful analogy here is recommending a recipe while leaving out half the ingredients.Beyond Hormone Levels: The 4 Steps Your Body Needs to Use Hormones (for Sleep & Beyond)Hormone support requires addressing the full functional pathway—not just circulating levels.Here’s what that pathway includes:* Raw materials and helpers: the basic inputs and small helpers your body uses to build hormones. If these are under-supplied, production slows.* How hormones are carried to where they’re needed. Most hormones are produced in one organ but used elsewhere. If transport is inefficient, even adequate hormone levels may not reach their destination effectively.* Receptor sensitivity: how effectively cells respond to available hormones. If receptors respond weakly, the signal is muted regardless of circulating levels.* Clearance patterns: the body’s “clean-up process” after hormones are used. If clearance slows, recycled ...
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    2 min
  • Does Short Sleep Impair Blood Sugar Control (Even with a Healthy Diet?)

    Does Short Sleep Impair Blood Sugar Control (Even with a Healthy Diet?)
    Dec 25 2025

    Resources:

    Sleep OS Hormones → https://thelongevityvault.com/sleep-os/hormones/

    Subscribe for more evidence-based guides on sleep in midlife and beyond → https://thelongevityvault.substack.com

    Does Short Sleep Impair Blood Sugar Control (Even with a Healthy Diet)

    Many adults in midlife and beyond consistently sleep less than 7 hours, even while eating well and staying active. This episode reframes that pattern as a metabolic signal: chronic short sleep steadily lowers insulin sensitivity in muscle and liver, so the pancreas must work harder to keep glucose in range.

    You’ll hear how this plays out in three groups—healthy adults, people with prediabetes, and “healthy but susceptible” adults with higher cardiometabolic risk—using data from large cohorts and a 6-week randomized sleep-restriction trial.

    Key points

    Large-scale data from ~247,000 UK adults show that sleeping under 6 hours per night raises type 2 diabetes risk over ~12 years, even after adjusting for diet quality, activity, BMI, blood pressure, and antidepressant use.

    Mechanistically, short sleep lowers insulin sensitivity in muscle and liver; blood sugar may remain “normal” at first, but only because the pancreas increases insulin output to compensate.

    Sleep duration emerges as a third modifiable pillar of diabetes prevention—alongside nutrition and physical activity.

    Listen for: How chronic short sleep alters insulin and glucose dynamics; why prediabetes status amplify that effect; and which structural changes can realistically add 20–40 minutes of sleep in midlife and later life.

    Read the full article: Does Short Sleep Impair Blood Sugar Control (Even with a Healthy Diet?)

    Learn more inside Sleep OS Hormones → https://thelongevityvault.com/sleep-os/hormones/



    This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit thelongevityvault.substack.com/subscribe
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    13 min
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