In this episode, Margaret unpacks one of the most overlooked pieces of women’s health, and that is detoxification.

She explains why perimenopause creates the “perfect storm” for toxin buildup, hormonal chaos, and inflammation, and how to support your body through this transition with practical, sustainable strategies.

From the liver-gut connection to emotional release, Margaret breaks down why detox isn’t about juice cleanses or quick fixes, but about restoring your body’s ability to process hormones, stress, and toxins efficiently. She shares actionable nutrition, mineral, and lifestyle strategies to improve energy, reduce PMS symptoms, and make your transition into menopause smoother and more empowered.

This episode is a must-listen for women in their late 30s and 40s who are feeling puffy, sluggish, or “stuck” in their health—and ready to finally understand what their body is asking for.

Episode Recap:

• What detox really means—and why it’s not about juice cleanses or saunas {01:20}
• How perimenopause slows detox pathways and raises estrogen load {04:50}
• The “perfect storm” of hormonal, liver, and stress overload during your late 30s–40s {05:40}
• Why liver and gut health determine how your hormones feel {8:53}
• Simple, functional detox support: food, minerals, bile flow, and bowel health {11:18}
• The link between nervous system regulation and hormonal balance {16:20}
• How emotions and stress block your body’s ability to detox {17:26}
• Why supporting detox now creates smoother hormones, better energy, and resilience long-term {20:46}

Links & References:

• Click here to order supplements through Fullscript
• Click here to order peptides with EllieMD, a US based telehealth provider.
• Book a peptide consult zoom call
• Download my GLP 1 Peptide Guide
• Join our 1:1 Coaching Program
• Learn more about working with our team by visiting fueledandfree.com
• Ep. 53 | Castor Oil Packs For Liver Detox, Thyroid, and Skin
• Ep. 67 | Estrogen Dominance In Perimenopause: Why You’re Bloated, Gaining Weight, Moody, & Have Heavy Periods

Connect with me on Instagram @margaretannpowell

**Disclaimer: The information shared in this podcast is NOT meant to be taken as individual or medical advice. Please seek the guidance of your physician or healthcare provider regarding any medical condition or treatment.

In this episode of the Fueled & Free Podcast, Margaret breaks down one of the most common sources of confusion in the wellness world — the difference between peptides and medications.

She explains what peptides actually are, how they work in the body, and why understanding their role can completely shift how you approach healing, longevity, and fat loss.

Margaret shares how peptides act as natural “messengers” that restore balance and repair, while medications tend to override the body’s systems to control symptoms. She also clarifies why some peptides, like GLP-1s, are regulated as drugs — and how others, such as BPC-157 or NAD+, support regeneration and optimization at the cellular level.

This episode is a must-listen for anyone curious about peptide therapy, confused by what’s “natural” vs. “pharmaceutical,” or ready to make more informed choices about how to support their metabolism, energy, and overall health.

Episode Recap:

• What peptides actually are and how it act as the body’s natural repair messengers {02:24}
• Examples of regenerative peptides like BPC-157, NAD+, and Tesamorelin + Ipamorelin {03:05}
• Why medications are designed to override or block pathways for specific outcomes {05:24}
• The “whisper vs. shout” analogy: peptides restore communication, medications command control {06:53}
• Why GLP-1s are regulated as medications, while other peptides remain wellness compounds {08:11}
• How quality peptides are so important and why these are powerful tools {14:50}
• How to use both strategically — peptides for restoration, medications for stabilization {18:20}
• A mindset shift: asking “Do I need to manage or to heal?” to guide your health decisions {22:05}

Links & References:

• Click here to order peptides with EllieMD, a US based telehealth provider.
• Book a peptide consult zoom call
• Download my GLP 1 Peptide Guide
• Join The Microdose Method GLP Coaching Group
• Join our 1:1 Coaching Program
• Learn more about working with our team by visiting fueledandfree.com
• Ep. 68 | Microdosing GLP-1s / Semaglutides: A Tool for Reducing Inflammation, Weight Loss & Insulin Resistance
  Ep. 75 | My 6 month update on microdosing a GLP 1, how peptides impact cravings, blood sugar, and can be a tool for longevity
  
  

Connect with me on Instagram @margaretannpowell

**Disclaimer: The information shared in this podcast is NOT meant to be taken as individual or medical advice. Please seek the guidance of your physician or healthcare provider regarding any medical condition or treatment.

In this episode of the Fueled & Free Podcast, Margaret shares her personal experience with microdosing GLP-1 peptides, and observations she’s had having coached clients who are microdosing GLP peptides.

She breaks down how microdosing can minimize side effects, support appetite regulation, and improve metabolic health, while emphasizing that it’s not a one-size-fits-all solution when it comes to fat loss.

Margaret also dives into the nuances of insulin resistance, hormone balance, and gut health — explaining why each person’s response to GLP-1s is unique, i.e. why some need a higher dose to get their body to respond.

This episode challenges the misconception that needing a higher dose means failure, and instead reframes it as part of a personalized journey toward better health.

Episode Recap:

• What microdosing really means and why it’s a smart, gentle starting point {01:42}
• Why microdosing can fall short for fat loss if deeper metabolic issues exist {03:47}
• Five reasons your body may not respond on a low dose (insulin resistance, receptor sensitivity, thyroid, undereating, gut health) {09:18}
• How to know when it’s time to move from microdosing to a therapeutic dose {17:09}
• Why needing a higher dose is not failure—it’s feedback from your body {24:44}
• The importance of flexibility over rigidity in your dosing journey {31:21}
• Why the microdosing phase still matters, even if you eventually titrate {32:00}

Links & References:

• Click here to order peptides with EllieMD, a US based telehealth provider.
• Book a peptide consult zoom call
• Download my GLP 1 Peptide Guide
• Join The Microdose Method GLP Coaching Group
• Join our 1:1 Coaching Program
• Learn more about working with our team by visiting fueledandfree.com
• Ep. 79 | How expectations can sabotage healing, lessons on letting go of timelines & surrendering to your health journey
• Ep. 75 | My 6 month update on microdosing a GLP 1, how peptides impact cravings, blood sugar, and can be a tool for longevity

Connect with me on Instagram @margaretannpowell

**Disclaimer: The information shared in this podcast is NOT meant to be taken as individual or medical advice. Please seek the guidance of your physician or healthcare provider regarding any medical condition or treatment.