The Accidental Birth Control: How a Testosterone Mistake Changed Medicine
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The Accidental Birth Control: How a Testosterone Mistake Changed Medicine
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A single lab error in 1938 produced a molecule that doctors prescribed to women for sixty-one years and that helped make oral hormone therapy possible - but it was born from a mistaken aim and carried a hidden chemical tension that later shaped contraception. How did a tweak meant to make testosterone swallowable become a progestogenic drug that fueled the contraceptive revolution?
In this episode, we trace the creation, commercial rollout, and clinical use of ethisterone, from the four chemists who synthesized it at Schering AG to the dosing and potency issues that revealed its androgenic origins - and we ask how that molecular accident changed medical practice and contraception.
Person: Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg, Arthur Serini
Date: 1938 (synthesis); 1939 (Proluton C); 1945 (Pranone US)
Location: Schering AG, Berlin
Topic: ethinyltestosterone / ethisterone oral progestogen
Period: 1938-late 20th century clinical use
- The molecule synthesized in 1938 was named ethinyltestosterone and later renamed ethisterone.
- Ethisterone bound to progesterone receptors with roughly 44% of the affinity of natural progesterone.
- To produce progestogenic effects physicians prescribed between 200 and 700 milligrams of ethisterone over 10-14 days.
- Tablets were manufactured in 5, 10, and 25 mg; capsules reached 50, 100, and 250 mg strengths.
- Norethisterone, the later replacement, proved approximately 20 times more potent than ethisterone.
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