Many adults notice a subtle change in midlife: energy, recovery, and focus shift, yet medical tests remain normal.

In this essay I explain why a competent physician may say “everything looks fine,” and why that statement can be technically correct while still leaving a person uncertain.

The issue is not lack of care, but a difference between what diagnostic medicine is designed to answer and what people are actually trying to understand.

This podcast discusses general patterns in medical reasoning and cannot assess individual health situations. Please speak with your own clinician regarding personal symptoms or concerns.

In Episode 1 of the Sokolov MD Podcast, plastic and reconstructive surgeon Rebecca Knackstedt, MD PhD, explains how prehabilitation improves surgical outcomes. We discuss protein dosing, immunonutrition, GLP-1 agonists, exercise, microbiome health, stress, and practical perioperative protocols to optimize recovery before surgery.

0:00:00 Intro
0:02:46 How Rebecca Developed Her Perioperative Care Framework. Clinical experience, evidence, and real-world patient management
0:05:06 What Is Prehabilitation? Definition, scope, and why it matters
0:06:27 Which Surgical Outcomes Can Prehabilitation Improve?
0:08:01 NUTRITION as the Foundation of Prehabilitation
0:08:27 Protein Intake Before Surgery: RDA vs optimal dosing and kidney injury concerns
0:16:28 Collagen Supplementation: Low-quality protein, clinical utility, or both?
0:20:14 GLP-1 and GIP Agonists in the Preoperative Setting
0:27:16 Recovery Drinks: Evidence-based support or marketing hype?
0:31:40 EXERCISE Prescription in Prehabilitation
0:34:43 “Banking Early”: Building physiological reserve before surgical stress
0:36:27 SUPPLEMENTS in Prehabilitation: What helps, what doesn’t, and what lacks evidence
0:45:13 Probiotics: Oral vs topical use in the perioperative period
0:51:59 Optimizing Wound Healing
0:55:05 STRESS MANAGEMENT with Prehabilitation. Optimizing the Hospital Environment
1:00:36 Can Patients Meaningfully Change Habits Before Surgery?
1:03:37 Prehabilitation Protocols: From “sprint” to comprehensive programs. Surgery as a Powerful Motivator for Behavior Change
1:09:14 Rapid-Fire Questions
1:10:57 The Single Most Important Thing to Do Before Surgery
1:11:44 Closing Thoughts
1:13:10 Medical Disclaimer