Phosphopenic Osteomalacia
Impossibile aggiungere al carrello
Rimozione dalla Lista desideri non riuscita.
Non è stato possibile aggiungere il titolo alla Libreria
Non è stato possibile seguire il Podcast
Esecuzione del comando Non seguire più non riuscita
Phosphopenic Osteomalacia
-
Letto da:
-
Di:
Phosphopenic disorders encompass conditions characterized by systemic phosphate wasting or deficiency, driven primarily by renal tubular defects, fibroblast growth factor 23 excess, or impaired gastrointestinal absorption. Key clinical manifestations include osteomalacia, rickets, muscle weakness, and profound fatigue. Diagnostic evaluation requires rigorous assessment of serum phosphate, fractional excretion of filtered phosphate, fibroblast growth factor 23 levels, and 1,25-dihydroxyvitamin D status. Management focuses on targeted etiology-specific therapy, incorporating phosphate supplementation combined with active vitamin D analogs to restore biochemical homeostasis and skeletal integrity while avoiding hypercalciuria and nephrocalcinosis.