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🔬In this episode of Oncology Spotlight - Expert Insights, Dr Yüksel Ürün, medical oncologist at Ankara University, reviews key studies presented at the ASCO Genitourinary Cancers Symposium, 2026.

The discussion focuses on clinically relevant trial results across bladder cancer, kidney cancer, and metastatic prostate cancer, highlighting data that may influence treatment decisions in daily oncology practice.

Key Studies Discussed:• KEYNOTE-B15 trial – Enfortumab vedotin + pembrolizumab in muscle-invasive bladder cancer- https://www.asco.org/abstracts-presentations/256834

• LITESPARK-011 – Belzutifan + lenvatinib after IO therapy in kidney cancer - https://www.asco.org/abstracts-presentations/256659

• LITESPARK-022 – Adjuvant belzutifan + pembrolizumab in high-risk kidney cancer - https://www.asco.org/abstracts-presentations/256660

• BRCAAway trial – Abiraterone + olaparib combination in metastatic castration-resistant prostate cancer - https://www.asco.org/abstracts-presentations/256832

Key Clinical Takeaways

✔ EV + pembrolizumab improves event-free survival in muscle-invasive bladder cancer ✔ Belzutifan combinations show promising activity in renal cell carcinoma ✔ Combination PARP inhibitor + ARPI therapy may significantly extend survival in selected mCRPC patients

A must-watch for oncologists and trainees looking for clear, clinically relevant takeaways from the latest GU oncology trials presented at ASCO GU26.

📌 CHAPTERS & TIMESTAMPS

🎙 00:08 – Introduction

👨‍⚕️ 00:14 – Meet Dr. Yüksel Ürün

🧬 00:20 – KEYNOTE-B15: EV + Pembrolizumab in Muscle-Invasive Bladder Cancer

📊 02:30 – Event-Free Survival & Pathologic Response Results

⚕️ 05:18 – LITESPARK-011: Belzutifan + Lenvatinib in RCC

📈 06:20 – Progression-Free Survival Improvement

💊 08:47 – LITESPARK-022: Adjuvant Belzutifan + Pembrolizumab

📉 10:01 – Disease-Free Survival Outcomes

🧪 11:34 – BRCAAway Trial: PARP + ARPI Combination

📊 13:00 – Survival Benefit in HRD-Mutated Prostate Cancer

🔬 15:16 – Clinical Implications for Practice

👋 15:24 – Closing Thoughts

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🔬In this episode of Oncology Spotlight, Dr. Shaqil Kassam shares a powerful perspective from the front lines of community oncology in Canada.

From drug access delays in publicly funded systems to the real-world challenges of administering bispecific therapies outside academic centers, this conversation dives into the complexity of modern oncology.

We also explore:

• Community vs academic oncology – what truly differs?

• The global equity gap in cancer care

• How AI is already transforming clinic workflows and pathology

• The real challenges behind sequencing new therapies

• Why equitable access remains the biggest global barrier
  

This is a must-watch for oncologists, trainees, and healthcare leaders navigating rapid innovation in constrained systems.

Check out the MedOncNow podcast: https://medoncnow.podbean.com/

📌 CHAPTERS & TIMESTAMPS

🏥 00:00 – The Biggest Issue: Drug Access in Public Healthcare

🎙️ 00:36 – Introduction & Guest Overview

👨‍⚕️ 01:07 – Dr. Kassam’s Journey to Medical Oncology

🌍 03:29 – Community vs Academic Oncology Explained

📊 06:33 – Are 80% of Patients Treated in Community Settings?

🤝 08:00 – Collaboration Between Community & Academic Oncologists

🎧 08:44 – The MedOncNow Podcast: Why It Started

💊 10:49 – Practical Implementation of New Cancer Drugs

🌎 13:07 – The Future of Oncology in Canada

⚖️ 16:05 – Equity: Canada’s Strength & Global Weakness

🌍 17:05 – Barriers to Global Cancer Care

🧠 21:40 – AI in Oncology: From Dictation to Digital Pathology

🎓 25:14 – Advice for Future Oncologists

📢 JOIN THE CONVERSATION! ❓Drop your thoughts in the comments below!📲 Oncology at your fingertips.

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🔬In this episode, Dr. Shreyas Kalantri shares his journey from medical training in India to academic oncology in the United States, and reflects on what truly defines progress in cancer care.

The conversation dives deep into quality of life as a critical endpoint, disparities in immunotherapy access, the role of academic research, global oncology collaboration, and how AI can reshape oncology workflows. Dr. Kalantri also discusses his work with the HemOnc Fellows Network and ASCO’s Training & Early Career Advisory Group, highlighting the importance of mentorship and democratizing oncology education worldwide.

This episode is essential listening for oncologists, trainees, and healthcare professionals navigating the rapidly evolving oncology landscape.

🔹 Key Topics Covered

• Why quality of life should contextualize survival outcomes

• Gaps in quality-of-life reporting in clinical trials

• The HemOnc Fellows Network

• Academic oncology vs community practice

• Global oncology and trainee mentorship initiatives

• AI, digital tools, and the future of oncology workflows

• Advice for trainees considering a career in oncology

🎬A must-watch episode for oncologists, trainees, and healthcare leaders shaping the future of cancer care.

Connect with Shreyas Kalantri here: https://www.linkedin.com/in/shreyaskalantrimd/

📲 Oncology at your fingertips.

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