Malignant Hyperthermia Deep Dive: Molecular Mechanisms, Early Recognition & Crisis Management with Core Anesthesia
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Malignant Hyperthermia Deep Dive: Molecular Mechanisms, Early Recognition & Crisis Management with Core Anesthesia
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In this episode, Chloe sits down with Tanner and Cole from Core Anesthesia for a high-yield, conversational breakdown of malignant hyperthermia - one of anesthesia’s most urgent and misunderstood crises. From the molecular dysfunction of the ryanodine receptor to the early OR red flags that every anesthesia provider must recognize, this episode blends science, clinical pearls, and real-world experiences that bring MH to life.
Together, they cover:
• What actually happens inside the muscle cell during an MH crisis
• Early recognition: unexplained ETCO₂ rise, rigidity, acidosis, and more
• Triggers, safe alternatives, and prepping an MH-safe anesthesia machine
• Dantrolene vs. Ryanodex in practice
• Postoperative management and recurrence risk
• Mental resilience in crisis management - and how to stop carrying every case home
Whether you’re a CRNA, SRNA, anesthesia student, or ICU nurse exploring the profession, this episode is packed with insight, support, and wisdom from three experienced clinicians and educators.