• Navigating Reproductive Psychiatry: Bipolar, Depression, and Postpartum Psychosis
    Feb 23 2026
    In this episode, we dive into the critical field of reproductive psychiatry to equip psychiatric nurse practitioners with the latest evidence-based strategies for managing pregnant and postpartum patients.... Listeners will learn how to differentiate psychiatric emergencies like postpartum psychosis from postpartum obsessive-compulsive disorder, and navigate complex medication decisions involving lithium, valproic acid, and novel treatments for postpartum depression like zuranolone.... We explore crucial clinical insights, including the necessity of adjusting lamotrigine and lithium doses during pregnancy and the importance of maintaining antidepressant regimens to prevent high relapse rates.... By understanding the nuanced risks of medication exposure versus untreated maternal illness, you will be empowered to conduct confident risk-benefit discussions and provide life-saving, collaborative care to this vulnerable population....
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    21 min
  • Deep Dive: What My Bones Know – Unlearning the Dread of Complex PTSD
    Feb 9 2026

    In this episode, we take an in-depth look at Stephanie Foo’s acclaimed memoir, What My Bones Know. A successful radio producer for This American Life and Snap Judgment, Foo seemed to have it all on paper, but behind the scenes, she was battling a constant, crushing anxiety she called "the dread".

    Join us as we explore her journey from a diagnosis of Complex PTSD (C-PTSD) to her relentless pursuit of healing. Unlike traditional PTSD, which is often linked to a single event, C-PTSD arises from chronic, repeated trauma—in Foo's case, years of severe physical and verbal abuse at the hands of her parents in San Jose, California.

    Key Topics Covered:

    Understanding C-PTSD: How Complex PTSD differs from traditional PTSD and why it creates a "relentless search for a savior".

    The Science of Trauma: We discuss the impact of Adverse Childhood Experiences (ACE) scores on physical health and life expectancy, and how trauma can literally reshape the brain.

    A Journalist’s Approach to Healing: Foo attacks her diagnosis like a reporter, interviewing scientists and experimenting with various therapies, including EMDR (Eye Movement Desensitization and Reprocessing) and restorative yoga.

    The Myth of the Model Minority: Foo investigates her hometown of San Jose to uncover the silent epidemic of intergenerational trauma within her immigrant community, challenging the idea of the "perfect" Asian American upbringing.

    Dr. Ham and the Hulk: We discuss the pivotal role of Dr. Jacob Ham, who taught Foo to reframe her rage (her "Hulk") not as a monster, but as a protective force to be thanked rather than shamed.

    From Broken to BADASS: The surprising twist where Foo learns that her trauma responses—specifically dissociation—can actually function as a superpower in times of crisis, a phenomenon researchers call BADASS (Blunted and Discordant Affect Sensitivity Syndrome).

    Memorable Quote: "Healing is never final. It is never perfection. But along with the losses are the triumphs... I am the beast’s master, and at the end of each battle I stand strong and plant my flag."

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    16 min
  • The 2026 Update: Navigating the New Medication Fact Book for Psychiatric Practice
    Jan 29 2026

    Are you a busy clinician looking for bottom-line assessments of the latest psychiatric medications? In this episode, we dive into the Eighth Edition of the Medication Fact Book for Psychiatric Practice. Authored by Talia Puzantian, PharmD, and Daniel J. Carlat, MD, this comprehensive 2026 update is designed to provide "need-to-know" information that can be quickly absorbed during a busy day of seeing patients.

    Join us as we explore the latest additions to this essential reference guide, including:

    • New FDA Approvals: We cover nine new fact sheets featuring recently approved treatments, such as the novel antipsychotic xanomeline/trospium (Cobenfy), the rapid-acting postpartum depression drug zuranolone (Zurzuvae), and the new antidepressant gepirone (Exxua).
    • Clinical Decision Tools: Learn about the book's 11 updated treatment algorithms and 33 quick-scan tables, covering everything from ADHD and mood stabilizers to somatic treatments like blue light blocking glasses.
    • Practical Practice Management: We discuss a brand-new appendix dedicated to navigating the frustration of prior authorization requests and denials, alongside updated guidance on dosing in hepatic and renal impairment.
    • Expanded Treatment Categories: Discover the latest protocols for anti-amyloid monoclonal antibodies in dementia care and updated strategies for managing side effects like weight gain and tardive dyskinesia.

    Whether you are a psychiatrist, nurse practitioner, or psychologist, this episode offers a preview of the algorithms and clinical pearls you need to streamline your prescribing practice.

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    17 min
  • Mental Illness as a Metabolic Disorder?
    Jan 29 2026

    This podcast discusses the emerging field of metabolic psychiatry, which posits that mitochondrial dysfunction is the fundamental biological root of mental illness. Rather than viewing psychiatric conditions solely as neurotransmitter imbalances, this framework suggests that disorders like depression and schizophrenia are manifestations of cellular energy failure in the brain. Research indicates a bi-directional link between metabolic diseases and mental health, where issues like insulin resistance can actually predict future psychiatric decline. Consequently, traditional medications may fail because they only address downstream symptoms instead of the underlying metabolic crisis. To bridge this gap, the text advocates for metabolic interventions such as the ketogenic diet, which may restore brain function by enhancing mitochondrial health and providing alternative fuel sources. This perspective seeks to integrate psychiatry with general medicine, reframing mental health as a reflection of the body's overall energy regulation and physical vitality.

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    12 min
  • Navigating Scope of Practice, Antipsychotic Switches, and Severe OCD Cases
    Feb 18 2026
    Join this insightful peer consultation session where psychiatric nurse practitioners navigate the complexities of clinical decision-making and private practice dynamics. The group explores the nuances of scope of practice, specifically debating when to manage medical comorbidities like migraines or withdrawal symptoms and the utility of "two-for-one" medications like topiramate. Listeners will gain practical strategies for switching antipsychotics, including specific tips on cross-tapering versus direct switching based on receptor occupancy. The episode also features a deep dive into a severe, treatment-resistant OCD case, examining augmentation strategies, TMS, and the critical role of Exposure and Response Prevention (ERP) therapy. These real-world discussions provide valuable support and clinical pearls for PMHMPs seeking to enhance their psychopharmacology skills and navigate complex patient scenarios.
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    18 min
  • When SSRIs Fail in OCD and Collaborative Suicide Assessment
    Feb 18 2026
    This episode dives into evidence-based strategies for treating Obsessive-Compulsive Disorder when first-line SSRIs fail, exploring augmentation options like ondansetron, memantine, and deep TMS.... We also sit down with Dr. David Jobes to discuss the Collaborative Assessment and Management of Suicidality (CAMS), a transformative framework that empowers patients by focusing on their specific drivers of suffering rather than just risk prediction45. Additionally, the discussion covers the rising popularity of transcranial direct current stimulation (tDCS), offering a clinical verdict on its safety and efficacy for depression compared to established treatments67. Finally, we review a recent meta-analysis regarding antipsychotic dosing, highlighting crucial differences in optimal therapeutic levels for acute mania versus schizophrenia89. Join us to expand your psychopharmacology toolkit and gain practical, life-saving insights for your most complex cases.
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    14 min
  • Managing Trisomy 21, Unmasking FASD, and Recognizing Dysmorphology
    Feb 17 2026
    Dive into the complex landscape of developmental disorders with a comprehensive look at managing Trisomy 21, Fetal Alcohol Spectrum Disorders (FASD), and clinical dysmorphology. We explore the psychiatric comorbidities of Down syndrome, offering evidence-based pharmacologic strategies for treating depression, anxiety, and ADHD while challenging implicit biases that limit patient potential. Expert insights reveal why over 85% of FASD cases are misdiagnosed and provide practical screening techniques to identify alcohol-related neurodevelopmental deficits that lack physical markers. The discussion extends to recognizing subtle genetic signs, such as those in 22q deletion syndrome, to help clinicians look beyond behavioral symptoms for underlying causes. We also evaluate new research on using topiramate to mitigate antipsychotic-induced weight gain and discuss the safety concerns surrounding vortioxetine in pediatric populations. This episode equips psychiatric NPs with the diagnostic tools and treatment updates necessary to improve long-term outcomes for neurodiverse youth.
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    15 min
  • Brexpiprazole Claims, Perinatal Psych, and Metformin Guidelines
    Feb 16 2026
    In this episode, we critically evaluate the expanding clinical profile of brexpiprazole, analyzing its recent FDA approval for agitation in Alzheimer’s dementia alongside the data behind its rejection for PTSD. We dive into perinatal mental health with Dr. Amritha Bhat, who offers expert guidance on navigating the risk-benefit analysis of psychotropics during pregnancy, the use of zuranolone, and first-line management for postpartum psychosis. Listeners will also discover new consensus guidelines that recommend prescribing metformin concurrently with high-risk antipsychotics to prevent metabolic side effects. We round out the discussion with recent research updates on the dose-dependent antidepressant effects of Vitamin D and the efficacy of service dogs for veterans. These evidence-based insights are essential for psychiatric nurse practitioners aiming to optimize treatment plans across the lifespan, from reproductive psychiatry to geriatric care.
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    14 min