We’re excited to be back for another episode of the Life Sciences Today Podcast by Healthcare IT Today. My guest today is Sagi Sigali, Father and Founder of Rafa’s Moonshot – a non-profit dedicated to Landing a Cure for STXBP1. Sagi and I discuss how Rafa’s Moonshot is turning a rare genetic disorder (STXBP1) into an investable, de‑risked therapeutic opportunity. Sagi explains how his tech/entrepreneur background shapes a for‑profit mindset around fundraising, biopharma partnerships, and making rare disease indications attractive to industry. They cover building a global network, leveraging grants and consortia, working with academia/CROs, and planning the flip from nonprofit to for‑profit. They also dig into industry “anti‑patterns,” including copy‑paste development strategies, and explore a strategy to start from the drug label and work backwards. Sagi closes with his vision for a complete STXBP1 solution, a new CNS neurogenetic research center in Israel, and a stronger Israeli life sciences ecosystem.

Check out the main topics of discussion for this episode of the Life Sciences Today podcast:

• How does Rafa’s Moonshot actually create value for drug and biotech companies working on STXBP1?
• What does the market and patient landscape look like for STXBP1 as a rare disease?
• How has your background as a serial tech entrepreneur influenced your strategy in rare disease therapeutics?
• What are you doing to make STXBP1 attractive enough to enter big‑pharma pipelines?
• How do conversations with academics, clinicians, CROs, and biopharmas translate into real progress?
• What is your consortium model, and how do grants and non‑dilutive funding fit into it?
• How are you using CROs in preclinical work and thinking about IP and cell line development?
• What do you see as the biggest anti‑pattern in rare disease/drug development today?
• What are the top three things you want to achieve for STXBP1 patients in the next year?
• What is your five‑year vision for STXBP1, for Rafa’s Moonshot, and for the Israeli life sciences ecosystem?

Now, without further ado, we’re excited to share with you the next episode of the Life Sciences Today podcast.

Subscribe to Danny’s newsletter to get strategic patterns for life science leaders building a defensible business.

Be sure to subscribe to the Life Sciences Today Podcast on your favorite podcasting platform:

• Apple Podcasts
• Spotify
• iHeartRadio
• Amazon Music
• Pandora
• YouTube

Along with the popular podcasting platforms above, you can Subscribe to Healthcare IT Today on YouTube. Plus, all of the audio and video versions will be made available to stream on Healthcare IT Today. As a former pharma-tech founder who bootstrapped to exit, I now help TechBio and digital health CEOs grow revenue—by solving the tech, team, and go-to-market problems that stall your progress. If you want a warrior by your side, connect with me on LinkedIn.

If you work in Life Sciences IT, we’d love to hear where you agree and/or disagree with our takes on health IT innovation in life sciences. Feel free to share your thoughts and perspectives in the comments of this post, in the YouTube comments, or privately on our Contact Us page. Let us know what you think of the podcast and if you have any ideas for future episodes.

Thanks so much for listening!

We’re excited to be back for another episode of the Life Sciences Today Podcast by Healthcare IT Today. My guest today is Zina Sarif, Founder and CEO at Yendou.

Zina Sarif is one of the most dynamic and inspirational founders I’ve met. She grew up in Morocco until age 20 and, after her PhD in biology, spent a decade in cancer drug discovery before leading clinical research at Parexel and PhIII oncology trials at AstraZeneca. Driven by the vision of a cancer-free world, she built Yendou to accelerate research, streamline site operations, and deliver life-saving treatments faster.

Yendou streamlines the site selection process and the interaction between CROs, sponsors, and sites, producing 2X improvements in productivity. One of my other guests from Lindus Health said it best, “Everyone is more productive with Yendou. We accelerated feasibility timelines by 50% while reducing manual follow-ups by 70%.”

Check out the main topics of discussion for this episode of the Life Sciences Today podcast:

• Tell us about your personal journey—how did you get from consulting and Viva to leading Ledger Run?
• Who are your customers, and what specific problems are you solving for them?
• How do you create value for sponsors and CROs in clinical trial site selection and relationship management?
• How do you capture that value—what does your business/revenue model look like?
• What is the biggest anti–design pattern you see in the industry right now?

Now, without further ado, we’re excited to share with you the next episode of the Life Sciences Today podcast.

Subscribe to Danny’s newsletter to get strategic patterns for life science leaders building a defensible business.

Be sure to subscribe to the Life Sciences Today Podcast on your favorite podcasting platform:

• Apple Podcasts
• Spotify
• iHeartRadio
• Amazon Music
• Pandora
• YouTube

Along with the popular podcasting platforms above, you can Subscribe to Healthcare IT Today on YouTube. Plus, all of the audio and video versions will be made available to stream on Healthcare IT Today. As a former pharma-tech founder who bootstrapped to exit, I now help TechBio and digital health CEOs grow revenue—by solving the tech, team, and go-to-market problems that stall your progress. If you want a warrior by your side, connect with me on LinkedIn.

If you work in Life Sciences IT, we’d love to hear where you agree and/or disagree with our takes on health IT innovation in life sciences. Feel free to share your thoughts and perspectives in the comments of this post, in the YouTube comments, or privately on our Contact Us page. Let us know what you think of the podcast and if you have any ideas for future episodes.

Thanks so much for listening!

We’re excited to be back for another episode of the Life Sciences Today Podcast by Healthcare IT Today. My guest today is John Chinnici, CEO at Ledger Run. I talk with Chinnici about his journey from consulting (Andersen, IBM) to Viva, where he helped launch and grow Vault, and eventually to leading Ledger Run. Ledger Run focuses on the “unsexy but critical” operational layer of clinical trials: contracting and paying investigative sites. Chinnici explains how delayed, incorrect, and bureaucratic payments have become an accepted but damaging status quo in clinical research, despite sites running on razor-thin margins.

Ledger Run’s SaaS platform and services aim to ensure strict contract compliance, dramatically improve operational efficiency, and turn reliable payments into a competitive advantage for sponsors in site recruitment. Chinnici also argues that a major industry anti-pattern is pouring AI investment into volatile early research use cases while underinvesting in high-ROI operational applications such as automating invoice processing and other repetitive payment workflows.

Check out the main topics of discussion for this episode of the Life Sciences Today podcast:

• Tell us about your personal journey—how did you get from consulting and Viva to leading Ledger Run?
• Who are your customers, and what specific problems are you solving for them?
• How do you create value for sponsors and CROs in clinical trial payments and contracts?
• How do you capture that value—what does your business/revenue model look like?
• What are three things you want to do for your customers in the next 12–18 months to make them insanely happy?
• What is your competitive moat—what makes Ledger Run hard to copy compared with large CROs and other players?
• What is the biggest anti–design pattern you see in the industry right now?

Now, without further ado, we’re excited to share with you the next episode of the Life Sciences Today podcast.

Subscribe to Danny’s newsletter to get strategic patterns for life science leaders building a defensible business.

Be sure to subscribe to the Life Sciences Today Podcast on your favorite podcasting platform:

• Apple Podcasts
• Spotify
• iHeartRadio
• Amazon Music
• Pandora
• YouTube

Along with the popular podcasting platforms above, you can Subscribe to Healthcare IT Today on YouTube. Plus, all of the audio and video versions will be made available to stream on Healthcare IT Today. As a former pharma-tech founder who bootstrapped to exit, I now help TechBio and digital health CEOs grow revenue—by solving the tech, team, and go-to-market problems that stall your progress. If you want a warrior by your side, connect with me on LinkedIn.

If you work in Life Sciences IT, we’d love to hear where you agree and/or disagree with our takes on health IT innovation in life sciences. Feel free to share your thoughts and perspectives in the comments of this post, in the YouTube comments, or privately on our Contact Us page. Let us know what you think of the podcast and if you have any ideas for future episodes.

Thanks so much for listening!