Len May says healthcare is really sick care: a cookie-cutter, insurance-reimbursed system that treats the symptom in a 15-minute visit and never asks what caused it. He is the CEO and co-founder of EndoDNA, a genetics-first decision-support platform for functional and integrative practitioners with 11 patents behind it, and a former California dispensary owner who got into genetics after watching two people react differently to the same varietal. His background is on the EndoDNA about page.

The method: read the DNA first, layer on bloodwork (a moment in time) and epigenetic markers, build a protocol across three levers (pharmaceutical, supplements, lifestyle), then close the loop with patient-reported outcomes plus what has been methylated or un-methylated, tuned over time by an LLM grounded on Anthropic's health model with EndoDNA's own guardrails.

Jeremy's full recap, with the endocannabinoid explainer and the grandma-at-chemo case written out, is at Len May: Cannabis, Your DNA, and Personalized Wellness.

In this episode

• Genes as a circuit breaker. Only 20 to 30 percent of the switches are on at birth. Food, environmental exposure and stress neurochemistry flip the rest.
• The stress-to-elbow-pain chain: a near miss floods you with cortisol, a genetic predisposition breaks down your own anandamide too fast, the immune system overreacts, and the doctor treats the elbow.
• Why a room of doctors went silent at Len's talk and then texted him questions for half an hour, and the LLM EndoDNA built so a practitioner can interrogate the genome in eighth-grade language on the EndoDNA platform.
• The endocannabinoid system, discovered in 1992, has nothing to do with smoking weed. Anandamide is Sanskrit for bliss. THC has a narrow therapeutic window, and today's 70 percent THC products are completely unnecessary.
• Addiction genetics: alcohol, opioid and amphetamine dependence genes plus impulsivity genes are a formula for disaster. Cannabis is not physically addictive, and sugar is probably more addictive than caffeine than cannabis.
• Grandma at chemo: a poor metabolizer on a high-THC gummy hallucinated and warned everyone off the devil's lettuce. Sublingual delivery, less THC, more CBD and linalool turned her into a walking referral. The full case is in his book Making Cannabis Personal.
• The tequila test. Nobody calls the tequila company after a rough night. Adults are accountable for the dose.
• Regulation: no federal testing standards, none at all for CBD, and a plea for federal quality control, prescribable tinctures and pharma collaboration without a ten-year FDA wait.
• Len's third book, Jack of All Trades, Master of Some, on ADHD and polymathy, and his show Everything is Personal. He posts as @lenmaydna on Instagram.

Related on Unscripted Cannabis: Mark Gillilan of Kyoto Botanicals on THC-free CBD, the founder Jeremy brings up on the regulation question,