How can we quantify changes in biology using rigorous, reliable and reproducible methodologies? In this conversation with Dr. Paul R. Territo, we delve deep into this critical aspect of neuroscience research. Changes in biology are caused by endogenous (eg., due to growth/ aging/ disease) or exogenous (eg., due to exposures/ pharmaceuticals) factors. Dr. Territo explains these complex processes and the approaches his team uses to measurethese changes to develop reliable ‘biomarkers’. Tune in to this informative episode that is fundamental to research and development of therapeutics. Over two episodes, Dr. Territo deconstructs the complexity of biomarker development and will deepen your understanding of biology more holistically.
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Dr. Territo received his Bachelors (1991) and Masters (1993) from California Polytechnic University, in Pomona CA, and his Ph.D. in 1996 from UNLV. During his postdoctoral fellowship at the Laboratory of Cardiac Energetics at the NIH’s National Heart, Lung, and Blood Institute (NHLBI), he received medical retraining and in the areas of noninvasive imaging technology and biophysics, which included Positron Emission Tomography (PET), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI). From that time forward, his research has focused on the development and application of imaging technologies to study disease progression, and evaluate the role of novel therapeutics on physiological processes. Leveraging these experiences, from 2001 to 2008, Dr. Territo as part of Eli Lilly’s drug discovery team developed novel imaging based biomarkers for therapeutic development in neuroscience, oncology, and cardiovascular disease. Shortly thereafter, Dr. Territo joined the faculty of Indiana University School of Medicine in the Department of Radiology and Imaging Sciences, where served as the Director of the Preclinical Imaging Core. Over this interval, Dr.Territo continued to develop novel imaging-based biomarkers for both preclinical and clinical assessment. In 2016, Dr. Territo began his independent laboratory focusing his research on developing state-of-the-art biomarkers formonitoring disease progression and then leveraging these for assessing therapeutic response for Alzheimer’s Disease and Related Dementia (ADRD).
Learn more about Dr. Territo via: https://medicine.iu.edu/faculty/6529/territo-paulContact Dr. Territo through: https://www.linkedin.com/in/paul-territo-696226a/-------------------------------------------------------------------
Dr. Jaya Viswanathan is a neuroscientist, author, and artist born and raised in India. She earned an engineering degree, a Master’s in neuroscience, and a Doctorate in cognitive neuroscience. Since her post-doctoral fellowship, she continues to deepen her neuroscientific expertise as a contractor at the National Institutes of Health. She was inspired to illustrate and write Baby Senses: A Sensory Neuroscience Primer for All Ages to convey complex scientific concepts through art and whimsy in terms of sensory “superpowers”. She has been interviewed on written, audio/podcasts, and video platforms where she makes neuroscience accessible to lay audiences. Tune into her podcast “Know Brainer” and other projects through which she disseminates science via https://babysensesbook.com/.