Intranasal Esketamine and the Placebo Response
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Intranasal Esketamine and the Placebo Response
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The paper we discuss in this episode is V Popova et al. Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined with a Newly Initiated Oral Antidepressant in Treatment Resistant Depression: A Randomized Double-Blind Active-Controlled Study. Am J Psychiatry 2019; 176(6): 428-438.
For a deeper understanding of the factors that contribute to placebo response, check out BR Rutherford and SP Roose. A Model of Placebo Response in Antidepressant Clinical Trials. Am J Psychiatry 2013; 170:723-733.
Lots of data about the placebo response in antidepressant clinical trials:
BT Walsh et al. Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing. JAMA 2002; 287(14):1840-1847.
W Rief et al . Meta-analysis of the Placebo Response in Antidepressant Trials. Journal of Affective Disorders 2009; 118:1-8.
TA Furukawa et al. Placebo Response Rates in Antidepressant Trials: A Systematic Review of Published and Unpublished Double-Blind Randomised Controlled Studies. Lancet Psychiatry 2016; 3:1059-1066.