In the Lab with Dr. Rashmi Mishra: Shapeshifting cancer into a more treatable form
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In the Lab with Dr. Rashmi Mishra: Shapeshifting cancer into a more treatable form
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John Higgins interviews Dr. Rashmi Mishra, a postdoctoral research fellow in the Hsieh Lab at Fred Hutch Cancer Center, about how aggressive prostate cancer shapeshifts from a form that is treatable with drugs to a more lethal form that is much less treatable. In a recent study, she and her colleagues found potential ways to reverse that trick, forcing tumor cells to shapeshift back into the more treatable form. Their discovery opens a new line of attack against aggressive prostate cancer, as well as breast cancer and possibly other cancers.
Key Takeaways:
- Prostate cancer comprises two main types of cells: luminal, which is more treatable with existing therapies and a more aggressive, lethal type called basal, which is much less treatable.
- A recent study by Dr. Rashmi Mishra, a postdoctoral research fellow in the Hsieh Lab at Fred Hutch Cancer Center, describes how prostate cancer shapeshifts from a luminal to a basal form to elude therapy without reprogramming its DNA.
- Mishra and her colleagues found potential ways to reverse that shapeshifting trick, forcing tumor cells to shapeshift back into the more treatable form.
- Their discovery opens a new line of attack against aggressive prostate cancer, as well as breast cancer and possibly other cancers.
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