Why do some weight-loss treatments work remarkably well for certain people, while others see little benefit?

In this final episode of a five-part Forbes Health series, Dr. Christopher Thompson brings together everything we’ve learned about weight biology and translates it into action. Rather than treating weight as a simple problem of willpower or calories, this episode explores how modern medications, endoscopic therapies, and surgery target different biological mechanisms, and why matching treatment to biology matters.

You’ll learn why one-size-fits-all approaches fail, how obesity phenotypes help explain variable treatment response, and how emerging therapies are reshaping personalized care. From phenotype-guided pharmacotherapy to cutting-edge endoscopic interventions and established surgical options, this episode walks through how each tool works, who it works best for, and why combination strategies are increasingly important.

If you’ve ever wondered why maintaining a healthy weight feels so different from person to person, this episode offers clarity, context, and a more humane framework for understanding treatment.

🔗 Read the full Forbes Health article here:

https://www.forbes.com/sites/christopherthompson/2025/12/31/how-modern-weight-loss-treatments-work-and-who-they-work-best-for/