Could reaction speed be the missing metric for brain health?

Dexter Ang shares how wrist-based neurotechnology quantifies cognition, personalizes interventions, & supports long-term mental performance for executives & elite performers.

Dexter Ang is the co-founder & CEO of Pison Technology, developing wearable neuromuscular sensing & nervous system interfaces. Inspired by caring for his mother after her ALS diagnosis, he returned to MIT to build sensors that translate wrist biopotentials into digital commands. His work bridges human biology & digital systems across assistive technology, robotics, IoT & defense.

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• Almost everyone operates at only 60–70% of their brain’s true potential due to low awareness
• Wrist sensors accurately measure cognitive state & nervous system signals without head worn devices
• NASA & clinical science use reaction time as the gold standard for measuring cognitive function, readiness, & risk
• Processing speed, inhibition, & agility are distinct cognitive dimensions, each revealing different aspects of brain health & decision making
• Reaction time biofeedback training produces measurable gains in attention, discipline, & mood regulation
• Individual responses vary widely, making personalized protocols far more effective than general advice
• Strong cognitive performance depends on quality sleep, consistent routines, & circadian rhythm discipline
• Caffeine improves alertness but often worsens decision inhibition, with effects varying by person & task
• Knowing personal cognitive highs & lows helps time important work & decisions for peak performance
• Processing speed training lowers dementia risk & strengthens long term brain resilience more than memory games

00:00 Measure Brain Performance with Real World Signals

01:20 Turn Personal Adversity into Cognitive Innovation

03:05 Use Reaction Time as a Core Brain Health Biomarker

07:54Train Cognition Through Feedback not Guesswork

14:02 Apply Cognitive Data to Performance & Resilience

33:58 Integrate Neural Data into Personalized Experimentation

• Watch it on YouTube: https://youtu.be/OAvyoLfz5uk
• Full episode show notes: outliyr.com/244

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Nick

What makes methylene blue so different from most nootropics is how little it takes to have an effect.

In this clip, Mark Sloan explains why ultra-low doses of methylene blue can support mental clarity, calm energy, and mitochondrial performance without overstimulation.

You’ll hear why:

• Just a few milligrams can support steady, all-day focus
• Low doses reduce risk while increasing safety and accessibility
• Methylene blue supports mitochondrial energy production at the cellular level
• It plays a role in the NAD to NADH ratio, a key marker of metabolic health
• The brain benefits disproportionately due to high energy demand

Tune in to Episode 68, where we go deeper into methylene blue, mitochondria, metabolic health, and why low-dose strategies often outperform aggressive protocols.

• Watch it on YouTube: https://youtu.be/q5PBJJAypDQ
• Full episode : https://outliyr.com/68

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Nick

Why does gut health affect your brain and metabolism so deeply?

Martha Carlin explains how the microbiome, endotoxin, & the glycocalyx influence energy, cognition, and long-term resilience & why gut repair is central to protecting longevity.

Martha Carlin is a pioneering citizen scientist & systems researcher who investigates the links between the microbiome, chronic disease & environmental toxins after her husband’s Parkinson’s diagnosis. She is the founder & CEO of The BioCollective, collaborating with leading institutions while developing BioFlux™ metabolic modeling & Sugar Shift®, a patented probiotic shown to improve metabolic health. Martha’s work bridges science & real-world application, empowering people to restore gut balance & transform whole-body health.

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• Be mindful of everything you eat & drink Your body reflects daily choices
• The modern food supply including chemicals & engineering drives or disrupts long-term wellness
• Your gut microbiome influences nearly every aspect of health, not just digestion
• Gut bacteria differences correlate with neurological disease profiles such as Parkinson’s
• Stool analysis reveals more health data than most expect Investigate output for internal clues
• Genetic material from food & microbes transfers into the body, influencing health in unexpected ways
• Single-strain probiotics fall short Full microbial teams support stronger gut ecosystems & outcomes
• Household chemicals damage the gut lining Auditing cleaning products protects barrier health
• Gut health depends on balance & relationships, not just which organisms exist
• Quality water & whole foods are the strongest foundational longevity levers so start there

04:12 Recognize the microbiome as a driver of chronic disease

05:51 Address the gaps in modern gut health care

17:25 How microbes adapt, share genes & influence biology

21:07 Build resilient microbial ecosystems instead of single strain fixes

41:05 Protect the gut lining to reduce inflammation system wide

• Watch it on YouTube: https://youtu.be/4Z1f2pr6QjY
• Full episode show notes: outliyr.com/243

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Nick