Can Alzheimer's Be Prevented?

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Can Alzheimer's Be Prevented?

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My nan had Alzheimer's. My mum has Alzheimer's. And I have two copies of APOE4.So, am I next?Or is there actually something I can do to prevent it?.......In this episode, I'm exploring one of the most personal questions I've ever asked - Can Alzheimer's actually be prevented, delayed or even reversed?I look at what APOE4 really means, why Alzheimer's can begin developing years before symptoms appear, and the growing research into lifestyle, metabolic health and personalised approaches to cognitive decline.I also explore the work of Dr Dale Bredesen and Dr Heather Sandison, including studies reporting improvements in cognitive function, alongside major research such as FINGER, US POINTER and ACTIVE.And I share something much closer to home: the conversation I wish I'd been able to have with Mum when her memory problems first began.In this episodeWhat Alzheimer's is, how it differs from dementia, and when memory changes deserve investigation.APOE4 genetics, family history and why increased risk isn't a guarantee.The 14 potentially modifiable dementia risk factors identified by the 2024 Lancet Commission.Conventional treatments, including memantine and newer anti-amyloid medicines.Dr Dale Bredesen's PreCODE and ReCODE programmes and the research behind them.Dr Heather Sandison's research into personalised approaches to cognitive impairment.What the WHO, FINGER and US POINTER research tells us about addressing multiple risk factors.Brain training, the ACTIVE trial, diet and supplements.Why it's never too early to start thinking about brain health - and why getting help for memory problems matters.My own experience of balancing Alzheimer's prevention with rheumatoid arthritis and chronic illness.Further reading, research & resourcesDr Dale Bredesen - The End of Alzheimer'sThe book that helped change how I thought about Alzheimer's, cognitive decline and the possibility of addressing multiple contributing factors.https://www.penguinrandomhouse.com/books/551532/the-end-of-alzheimers-by-dale-e-bredesen-md/Free 15 Minute CVQ Assessment From Dr Dale Bredesen (online) https://www.apollohealthco.com/know-your-cq/Bredesens Seven Strategies to Optimise Brain Health - https://www.apollohealthco.com/the-bredesen-seven/Bredesen's 25 person pilot study (2022)Research reporting cognitive improvements in participants with mild cognitive impairment or early Alzheimer's following a personalised programme.https://pmc.ncbi.nlm.nih.gov/articles/PMC9484109/Bredesen's randomised controlled trial - 73 participants (2026 preprint)An encouraging next step in investigating personalised interventions, with positive results on several cognitive measures. At the time of recording, the report was available as a preprint rather than a peer-reviewed journal publication.https://www.preprints.org/manuscript/202512.2694Dr Heather Sandison - personalised lifestyle intervention (2023)A published study reporting improvements in several cognitive assessments following a six-month programme.https://pubmed.ncbi.nlm.nih.gov/37355891/FINGER Trial - Finland (2015)A landmark randomised trial investigating a combination of nutrition, exercise, cognitive training and vascular risk management.https://pubmed.ncbi.nlm.nih.gov/25771249/US POINTER Trial (2025)A major US trial comparing structured and self-guided multidomain lifestyle interventions for cognitive health.https://www.alz.org/us-pointer/study-resultsACTIVE Trial - 20-year follow-up (2026)Research investigating whether particular types of cognitive training were associated with fewer subsequent dementia diagnoses.https://pmc.ncbi.nlm.nih.gov/articles/PMC12884427/World Health Organization - Dementia Risk Reduction Guidelines (2026)Updated recommendations on lifestyle, health conditions, environmental risk factors and tailored multidomain interventions.https://www.who.int/publications/i/item/9789240123557The Lancet Commission - Dementia Prevention, Intervention and Care (2024)The report identifying 14 potentially modifiable risk factors associated with an estimated 45% of dementia cases worldwide.https://doi.org/10.1016/S0140-6736(24)01296-0Alzheimer's Research UK - Reducing Your Risk of DementiaPractical, research-informed information about brain health and factors we may be able to influence.https://www.alzheimersresearchuk.org/dementia-information/reducing-your-risk/Alzheimer's Research UK - Genes and Dementia RiskInformation about the role of genetics alongside lifestyle, age and environmental factors.https://www.alzheimersresearchuk.org/dementia-information/genes-and-dementia/can-i-reduce-my-risk-of-dementia/Dementia information and supportAlzheimer's Society - Dementia Support LineAdvice and practical support for people living with dementia, their families and carers.0333 150 3456https://www.alzheimers.org.uk/get-support/dementia-support-lineDementia UK - Admiral Nurse Dementia HelplineFree specialist dementia nursing advice and support.0800 888 6678https://www.dementiauk.org/...

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