What happens when the person trained to assess clinical risk becomes the patient at the center of a life-threatening event?

In episode 49 of Built by Margin, Laurie Chen speaks with Kristin Gype, DNP, MSQM, APRN-CRNA, CNE, a lead CRNA, healthcare entrepreneur, adjunct instructor, and Duke Fuqua MSQM alum. Kristin shares how her background in anesthesia, healthcare analytics, patient safety, and mental health education has shaped the way she thinks about risk, decision-making, and innovation in healthcare.

The conversation explores the limits of today’s healthcare risk assessment tools, the opportunity for AI and data analytics to improve patient safety, and why human connection still matters deeply in a system increasingly focused on speed, volume, and automation. Kristin also shares the personal story of surviving a near-death experience during childbirth, and how that moment reshaped her perspective on wellness, healthcare leadership, and what it means to advocate for patients.

From clinical decision support to value-based care, mental health first aid, and the future of healthcare innovation, this episode is a powerful look at how numbers, risk, and humanity intersect when the stakes are highest.

Quotes

• "The tools we’re using in healthcare to assess risk are still in their infancy. We need to build them more robustly with technology and AI, because there are so many patient outcomes we still don’t have risk tools for." – Kristin Gype
• “Owning your own business is like drinking from a fire hose. You’re always learning — and you’re taking on risk from every side: legal, financial, operational, and human.” - Laurie Chen

Laurie Chen

Instagram: https://www.instagram.com/lauriechencpamba/

LinkedIn: https://www.linkedin.com/in/lauriechen/

Risk Worthy: https://www.riskworthy.co/

Kristin Gype

LinkedIn: https://www.linkedin.com/in/kristinmgype/

In episode 48 of Built by Margin, Laurie Chen speaks with John Konhilas, founder, professor, and Chief Science Officer at BioXGen, about what it really takes to turn scientific discovery into a product that can reach patients.

John shares his unconventional path from studying art at Duke University to earning a PhD in physiology, spending nearly two decades as a professor at the University of Arizona, and building ventures at the intersection of women’s health, heart disease, microbiome research, and medical device innovation. He discusses the lessons from scaling and exiting Menolabs, including how data, consumer behavior, and timing shaped the company’s trajectory.

The conversation then moves into BioXGen’s patent-pending single-use cardiac patch, designed to be placed directly on the heart during open-heart surgery to support healing during the highest-risk post-operative period. John explains the technical, clinical, and adoption risks behind the product, why surgeon buy-in matters, and how the company is pursuing an FDA 510(k) pathway to create a faster and more capital-efficient route to market.

Laurie and John also discuss capital strategy, including self-funding, friends-and-family investment, and BioXGen’s current Regulation CF raise. John shares why he believes in “science for the people,” how AI may accelerate medical device customization, and why founders building serious medical innovations need diligence, partnerships, and the willingness to step outside their comfort zone.

This episode is a powerful look at how discovery becomes utility — and how risk, science, regulation, capital, and persistence all come together when building something that could change patient outcomes.

Quotes

• "It’s not always the best idea that makes it to the patient. It takes the right people, the right environment, and the willingness to bring science into the real world." – John Konhilas
• “Medical innovation is not just a science problem. It’s a risk, capital, regulatory, and execution problem.” - Laurie Chen

Laurie Chen

Instagram: https://www.instagram.com/lauriechencpamba/

LinkedIn: https://www.linkedin.com/in/lauriechen/

Risk Worthy: https://www.riskworthy.co/

John Konhilas

LinkedIn: https://www.linkedin.com/in/johnkonhilas/

BioXgen: https://invest.bioxgen.life

In episode 47 of Built by Margin, Laurie Chen sits down with Adi Daryanani, founder and CEO of Lyncoris, to talk about the hidden complexity behind dental insurance, billing, and collections. After acquiring a dental practice with his wife, Adi saw firsthand how fragmented and manual the insurance verification and claims process still is for independent practices. That experience became the foundation for Lyncoris, a platform designed to bring eligibility, claims, patient billing, and denial management into one more centralized workflow.

Adi shares how his background in engineering, analytics, data systems, and product development shaped the way he approached the problem. He explains why dental billing is especially hard to automate, how payer fragmentation creates operational friction, and why AI is helpful but still needs human judgment for edge cases. The conversation also covers the risk decision behind acquiring an existing dental practice instead of starting one from scratch, the importance of testing software in real-world workflows, and the trap founders face when they confuse personal access to a problem with full market understanding.

This episode is a great listen for founders building from lived experience, healthcare operators managing administrative complexity, and anyone interested in how AI, automation, and human expertise can work together to make small business operations leaner and more scalable.

Quotes

• "AI does help to build a lot of the scaffolding around workflows and processes and problems. But you ultimately need a reviewer or someone who can verify that that is correct." – Adi Daryanani
• " We shouldn’t confuse access to the problem with understanding of the market." – Adi Daryanani
• “Having experienced your own pain point, you’re able to better diagnose and solve the problem for someone else who’s probably experiencing it as you are.” - Laurie Chen

Laurie Chen

Instagram: https://www.instagram.com/lauriechencpamba/

LinkedIn: https://www.linkedin.com/in/lauriechen/

Risk Worthy: https://www.riskworthy.co/

Adi Daryanani

LinkedIn: https://www.linkedin.com/in/daryanani/

Lyncoris: https://lyncoris.com/