Anticoagulants don’t have to feel overwhelming. In this solo episode, CRNA educator Chloe Gomez, DNP, CRNA breaks down the coagulation cascade and anticoagulant pharmacology in a clear, intuitive way designed for SRNAs, CRNAs, and anesthesia providers preparing for boards and real-world clinical practice.

We start with a simple, step-by-step walkthrough of the intrinsic, extrinsic, and common pathways, then connect that physiology directly to how commonly used anticoagulants work — including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), warfarin (Coumadin), and direct oral anticoagulants (DOACs).

This episode goes beyond memorization and focuses on mechanism-based understanding, explaining:

• Why heparin potentiates antithrombin III and primarily inhibits factor IIa (thrombin) and factor Xa

• Why PT/INR rises first with warfarin due to factor VII’s short half-life — not because warfarin “blocks the extrinsic pathway”

• How DOACs selectively target factor Xa or thrombin

• Which labs actually reflect drug effect (aPTT, PT/INR, ACT, anti-Xa)

• How electrolyte imbalances can turn anticoagulants into pro-arrhythmics or bleeding risks

We also cover high-yield anesthesia considerations, including:

• Neuraxial anesthesia timing and safety

• ASRA-aligned anticoagulant hold times

• Reversal agents (protamine, vitamin K, PCCs, andexanet alfa, idarucizumab)

• Practical OR case scenarios you are likely to see in real practice

If you’re studying for the NBCRNA NCE, teaching anesthesia pharmacology, or just want anticoagulants to finally make sense, this episode is designed to help you stop memorizing tables - and start building safe anesthetic plans.

🎧 Educational, board-relevant, and clinically grounded - this is anticoagulation for anesthesia providers who want to truly understand the “why.”