In this episode of Inflammatory Content, Dr. Kellen Cavagnero explores the debilitating skin disease hidradenitis suppurativa (HS) and takes a deep dive into a recent Immunity paper that comprehensively examines the role of tertiary lymphoid structures in HS pathogenesis. HS has long defied simple classification, with prevailing disease models emphasizing hair follicle dysfunction, aberrant wound healing, or chronic inflammation. This work adds a new dimension by implicating autoimmunity as a central contributor to HS pathogenesis, further underscoring the complexity of the disease.

Relevant Links:

• Paper: https://pmc.ncbi.nlm.nih.gov/articles/PMC12404358/

• Commentary: https://pmc.ncbi.nlm.nih.gov/articles/PMC11790253/

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