The island city of Tyre along the coast of Lebanon was for centuries an impregnable fortress and key to unlocking Phoenician and Persian power in the Near East. Its fall was first prophesied in the Book of Ezekiel; but it would not be Nebuchadnezzar, king of Babylon, who would take the city as the Bible foretold, but a Macedonian warrior king, Alexander. Alexander's siege of 332 BC was one of the most remarkable events in the classical world.

The Siege of Tyre is the first book-length treatment of this critical and fascinating campaign, featuring catapults, triremes, religious invocations, close combat, and marvels of engineering, including a massive man-made causeway from the mainland to the island. The siege is thoroughly analyzed from the standpoint of what is plausible given the nature of the technology of the time and what we now know of the geology and physical fortifications of ancient Tyre. Critical to the siege were evolving technologies, including innovations in catapult design, military engineering, and naval architecture. David A. Guenther also takes into account recent scientific discoveries about the geology of the ancient seabed around Tyre and its effect on the siege. Finally, the book points out possible gender-biased views on topics such as sacred temple prostitution and the fate of women in besieged cities of the ancient world.