The Neuroscience of Fasting: 3 Days With Jesus and the Feeding of the 4,000 copertina

The Neuroscience of Fasting: 3 Days With Jesus and the Feeding of the 4,000

The Neuroscience of Fasting: 3 Days With Jesus and the Feeding of the 4,000

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Season 2, Episode 2Show NotesWhat happens to your brain after three days without food? Can fasting affect cellular repair, hormone production, and how your brain uses energy?In this episode of The Christian Mind Reset, Dr. April Joy explores the fascinating neuroscience of fasting, its history throughout Scripture and the early Christian church, and what researchers are discovering about the human body’s remarkable ability to adapt during prolonged periods without food.As a board-certified psychiatric mental health nurse practitioner, psychotherapist, Bible teacher, and student of neuroscience, Dr. April Joy examines human studies demonstrating significant physiological changes during prolonged fasting, including a thirteenfold increase in the brain’s uptake of ketones after approximately three and a half days, a fivefold increase in growth hormone production after two days, and significant changes in more than 1,000 circulating proteins during a seven-day fast.The episode also explores autophagy, cellular recycling, metabolic switching, stem-cell research, and the history of fasting from Moses and Esther to Jesus and the early Christian church.But the inspiration for this episode began while Dr. April Joy was teaching Vacation Bible School and preparing a lesson about Jesus feeding the 4,000.In Mark 8, we learn that the crowd had remained with Jesus for three days. Could some of the physiological changes researchers observe during prolonged fasting have been happening in those who went without food?Scripture doesn’t tell us how long each person had fasted, but it does tell us something remarkable about Jesus.He saw their hunger, had compassion on them, and provided for all of their needs.The episode concludes with Jesus’ declaration in John 6:35:“I am the bread of life. He who comes to Me shall never hunger, and he who believes in Me shall never thirst.”Listeners are invited to reflect on God’s provision through Scripture, guided relaxation, biblical declarations, journaling, and prayer.In This Episode* The biblical history of fasting and the early Christian church* What happens to the brain after 48–72 hours without food* Ketones, metabolic switching, and brain energy* Autophagy and cellular maintenance* Growth hormone, stem cells, and immune-system research* The 2024 human study identifying widespread protein changes* Jesus feeding the 4,000 and His compassion for our physical needs* Jesus as the Bread of Life* Scripture-based declarations, prayer, and practical applicationConnect with Dr. April JoyIf you enjoyed today’s episode, please subscribe, leave a review, follow, like, or share it with someone who might benefit from this conversation.Find Dr. Joy on Instagram at @thechristianpsychnp and on Substack for more Scripture, neuroscience, and practical tips to renew your mind.Listen to The Christian Mind Reset on Apple Podcasts, Spotify, YouTube, and Substack.The companion eBook, The Christian Mind Reset: A 28-Day Psalms Guide to Biblical Meditation, Neuroscience, and Renewing Your Mind, supports Season 1 and is available in Dr. Joy’s Stan Store at https://stan.store/thechristianpsychnp and on Dr. Joy’s Instagram and Substack profile links.Scriptures ReferencedExodus 34:28Esther 4:15–162 Chronicles 20Jonah 3Isaiah 58Psalm 23:1Psalm 139:14Matthew 4:1–11Matthew 6:16–34Mark 8:1–10John 1:1–3John 6:35Acts 13:1–3Colossians 1:161 Peter 5:7ReferencesAlkurd, R., Mahrous, L., Zeb, F., Khan, M. A. B., Alhaj, H., Khraiwesh, H. M., & Faris, M. E. (2024). Effect of calorie restriction and intermittent fasting regimens on brain-derived neurotrophic factor levels and cognitive function in humans: A systematic review. Medicina, 60(1), Article 191. https://doi.org/10.3390/medicina60010191Cheng, C.-W., Adams, G. B., Perin, L., Wei, M., Zhou, X., Lam, B. S., Da Sacco, S., Mirisola, M., Quinn, D. I., Dorff, T. B., Kopchick, J. J., & Longo, V. D. (2014). Prolonged fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression. Cell Stem Cell, 14(6), 810–823. https://doi.org/10.1016/j.stem.2014.04.014da Silva, J. S. V., Seres, D. S., Sabino, K., Adams, S. C., Berdahl, G. J., Citty, S. W., Cober, M. P., Evans, D. C., Greaves, J. R., Gura, K. M., Michalski, A., Plogsted, S., Sacks, G. S., Tucker, A. M., Worthington, P., Walker, R. N., & Ayers, P. (2020). ASPEN consensus recommendations for refeeding syndrome. Nutrition in Clinical Practice, 35(2), 178–195. https://doi.org/10.1002/ncp.10474de Cabo, R., & Mattson, M. P. (2019). Effects of intermittent fasting on health, aging, and disease. The New England Journal of Medicine, 381(26), 2541–2551. https://doi.org/10.1056/NEJMra1905136The Didache. (n.d.). Chapter 8: Concerning fasting and prayer. New Advent. https://www.newadvent.org/fathers/0714.htmHartman, M. L., Veldhuis, J. D., Johnson, M. L., Lee, M. M., Alberti, K. G., Samojlik, E., & Thorner, M. O. (1992). Augmented growth hormone (GH)...
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