Lead: The effect of stimulant medications on symptom and treatment outcomes in adults with comorbid attention-deficit/ hyperactivity and substance use disorder: A systematic review and meta-analysis
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Lead: The effect of stimulant medications on symptom and treatment outcomes in adults with comorbid attention-deficit/ hyperactivity and substance use disorder: A systematic review and meta-analysis
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The effect of stimulant medications on symptom and treatment outcomes in adults with comorbid attention-deficit/ hyperactivity and substance use disorder: A systematic review and meta-analysis
Journal of Attention Disorders
ADHD and SUDs have shared genetic vulnerability and 20% of people with a SUD have co-occurring ADHD. This systemic review and meta-analysis assessed the risks and benefits of stimulant treatment in patients with both diagnoses. Seven studies met inclusion criteria; six were randomized controlled trials. Among patients with co-occurring SUD and ADHD, comparing those prescribed stimulants to those not prescribed stimulants, there was no evidence for a difference in substance use, SUD symptoms, substance abstinence, or ADHD treatment adherence. Only 2 of 5 studies showed improvement in ADHD symptoms with stimulant treatment. One study found significantly longer SUD treatment retention in those prescribed stimulants. Although there was no clear evidence of harm associated with treatment with stimulants, they caution that significant limitations in the quality of evidence result in low confidence for all these conclusions.
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