82. Is Depression a Metabolic Problem? Dr. Chris Palmer, Insulin Resistance, and Mental Health
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82. Is Depression a Metabolic Problem? Dr. Chris Palmer, Insulin Resistance, and Mental Health
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Depression and anxiety may be more connected to metabolism than most people realize.
In this episode, Dave breaks down metabolic psychiatry, the emerging field connecting insulin resistance, ketosis, and brain health, and shares his own experience with intermittent fasting that led him to this research.
Drawing on Harvard psychiatrist Dr. Chris Palmer's work and the nonprofit Metabolic Mind, Dave covers what recent clinical studies actually show.
Topics covered:
- Dave's personal intermittent fasting routine and the blood sugar shifts he noticed
- Dr. Chris Palmer's Brain Energy theory: why mental disorders may be metabolic disorders of the brain
- Research showing people with insulin resistance are twice as likely to develop major depression
- A 2025 JAMA Psychiatry meta-analysis on ketogenic diets, depression, and anxiety
- A 12-week study showing a 62 percent reduction in depression scores using ketogenic metabolic therapy
- Why children with insulin resistance are 5 times more likely to have a mental illness
- A challenge to notice how your own blood sugar affects your mood and mental clarity
If you've ever wondered whether what you eat is connected to how you feel mentally, this episode lays out the research.
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