invisible pharmacology at a public event
Impossibile aggiungere al carrello
Puoi avere soltanto 50 titoli nel carrello per il checkout.
Riprova più tardi
Riprova più tardi
Rimozione dalla Lista desideri non riuscita.
Riprova più tardi
Non è stato possibile aggiungere il titolo alla Libreria
Per favore riprova
Non è stato possibile seguire il Podcast
Per favore riprova
Esecuzione del comando Non seguire più non riuscita
invisible pharmacology at a public event
-
Letto da:
-
Di:
Calmness can be manufactured: a cardiac drug patented in 1962 and approved in 1964 was later found to concentrate in the brain up to 33 times more than in blood, altering memory, fear and performance in ways no regulator had anticipated. How did a medicine meant for failing hearts become an invisible influence on minds and public life?
In this episode, we trace the history, chemistry and unexpected journeys of propranolol from its invention to widespread use, and ask where medicine ends and other forms of control begin.
Person: James W. Black
Date: 1962 (patent), 1964 (approval)
Location: Alderley Park, Cheshire
Topic: Propranolol pharmacokinetics and uses
Event: 1964 Tokyo pistol shooting (arm stillness observed)
- Propranolol was patented in 1962 and approved for human use in 1964.
- The drug was marketed under the trade name Inderal one year after approval.
- Only about 25% of an oral dose survives first-pass metabolism to circulate systemically.
- Propranolol accumulates in the brain at 15 to 33 times the concentration found in blood.
- In a single year it reached number 69 on the US prescription list and was dispensed over nine million times.
To listen to this podcast ad-free and access premium episodes, try our subscription with a 14-day free trial at obomedia.com.
© 2026 OBOMEDIA. All rights reserved.
This episode and its content (audio, text, and related materials) are the exclusive property of OBOMEDIA and are protected by applicable copyright laws. Reproduction, distribution, editing, or commercial use, in whole or in part, without prior written permission from OBOMEDIA is prohibited. For permissions, licensing, and business inquiries: business@obomedia.com.
adbl_web_anon_alc_button_suppression_t1
Ancora nessuna recensione