After Life is a collective history of how Americans experienced, navigated, commemorated, and ignored mass death and loss during the global COVID-19 pandemic, mass uprisings for racial justice, and the near presidential coup in 2021 following the 2020 election. Inspired by the writers who documented American life during the Great Depression and World War II for the Works Progress Administration (WPA), the editors asked twenty-first-century historians and legal experts to focus on the parallels, convergences, and differences between the exceptional "long 2020", while it unfolds, and earlier eras in US history.

Providing context for the entire volume, After Life's Introduction explains how COVID-19 and America's long history of inequality, combined with a corrupt and unconcerned federal government, produced one of the darkest times in our nation's history. Discussing the rise of the COVID-19 death toll in the United States, eventually exceeding the 1918 flu, the AIDS epidemic, and the Civil War, it ties public health, immigration, white supremacy, elections history, and epidemics together, and provides a short history of the Black Lives Matter protests of 2020 and the beginnings of a Third Reconstruction. After Life documents how Americans have dealt with grief, pain, and loss, both individually and communally, and how we endure and thrive.